A5066697985- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- BRCA gene mutations in cancer
- Glutathione Transferases and Polymorphisms
- Cancer-related Molecular Pathways
- Pituitary Gland Disorders and Treatments
- Ferroptosis and cancer prognosis
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Genetic factors in colorectal cancer
- Ophthalmology and Eye Disorders
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Vitamin D Research Studies
- Herpesvirus Infections and Treatments
- Radiation Dose and Imaging
- Neonatal Health and Biochemistry
- Science and Education Research
- RNA modifications and cancer
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
Universidade Estadual de Campinas (UNICAMP)
2016-2025
Pacific Northwest National Laboratory
2024
Emory University
2023
University of Illinois Chicago
2023
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2021
Universidade do Porto
2021
IPO Porto
2021
Pontifícia Universidade Católica de Campinas
2017
Centro Universitário da Cidade
2017
St George's Hospital
2016
Aims : To investigate the usefulness of immunohistochemical expression and immunolocalization a panel thyroid malignancy markers including HBME‐1, cytokeratin (CK) 19 galectin‐3. Methods results We evaluated 170 lesions 148 neoplastic [84 papillary carcinomas (PC), 38 follicular (FC), 18 adenomas, one hyalinizing trabecular tumour, five medullary carcinomas, two anaplastic carcinomas] 22 non‐neoplastic (12 adenomatous nodules 10 Hashimoto's thyroiditis). galectin‐3 CK19 were expressed in...
The aims of these recommendations were to develop clinical guidelines for evaluation and management patients with differentiated thyroid cancer applicable Latin American countries. panel was composed by 13 members the Thyroid Society (LATS) involved research from different medical centers in America. produced on basis expert opinion use principles Evidence-Based Medicine. Following a group meeting, first draft based evidences opinions elaborated and, later, circulated among members, further...
Immune responses against differentiated thyroid carcinomas (DTC) have long been recognized. We aimed to investigate the role of immune cell infiltration in progression DTC.We studied 398 patients - 253 with papillary and 13 follicular cancers, as well 132 nonmalignant tissues.Immune was identified using CD3, CD4, CD8, CD20, CD68 FoxP3 immunohistochemical markers. In addition, we assessed colocalization CD4 IL-17 identify Th17 lymphocytic CD33 CD11b myeloid-derived suppressor cells...
Thyroid nodules are frequent findings, especially when sensitive imaging methods used. Although thyroid cancer is relatively rare, its incidence increasing, particularly in terms of small tumors, which have an uncertain clinical relevance. Most patients with differentiated exhibit satisfactory outcomes treatment appropriate, and their mortality rate similar to that the overall population. However, relapse occurs a considerable fraction these patients, some stop responding conventional...
Background: Low doses of antithyroid drugs (ATD) for extended periods may be an alternative Graves' disease (GD) patients who relapse after a course ATD. Methods: Patients with GD (n = 238) discontinuation ATD therapy 12–24 months were retrospectively analyzed in nonrandomized study. Radioiodine (RAI) treatment and L-thyroxine replacement was used 114 patients, low dose methimazole (MMI; 2.5–7 mg/daily) 124 patients. Thyroid dysfunction, ophthalmopathy (GO) evolution, quality life (QoL),...
Exames laboratoriais são fundamentais para o diagnóstico acurado e monitoramento custo-efetivo das disfunções tireoidianas. Quando há alta suspeita clínica, as dosagens hormonais apenas confirmam diagnóstico. No entanto, na maioria dos pacientes, a sintomatologia é sutil inespecífica, de forma que testes bioquímicos podem detectar transtorno. O objetivo deste artigo fazer uma análise crítica do uso apropriado principais função tireoidiana, entre eles dosagem sérica hormônio estimulante da...
B7H1 is consistently associated with inhibition of the immune system in many solid tumors. However, there no report about its impact on differentiated thyroid carcinoma (DTC) presentation, aggressiveness, or evolution. Aiming to investigate role DTC and correlate this protein other tumor-infiltrating cells, we studied 407 nodule tissue samples including 293 from patients, all managed according a same standard protocol. In addition, obtained 5 normal 114 benign lesions. Eighteen out 253...
Loss of heterozygosity (LOH) studies have been used to identify sites harboring tumor suppressor genes involved in initiation or progression. Previous reports suggested that regions within chromosomes 3p, 11q, 2p, 2q, 10q, and 1p may be frequently deleted human follicular thyroid cell tumors. We extended the analysis these other selected 65 paired tissues. Twenty-four were adenomas, 30 papillary carcinomas, 10 1 was an anaplastic carcinoma. Sixty percent 33% 23% carcinomas presented LOH at...
Germline mutations in the Exostoses-1 gene (EXT1) are found hereditary multiple exostoses syndrome, which is characterized by formation of osteochondromas and an increased risk chondrosarcomas osteosarcomas. However, despite its putative tumor-suppressor function, little known contribution EXT1 to human sporadic malignancies. Here, we report that function abrogated cancer cells transcriptional silencing associated with CpG island promoter hypermethylation. We also show that, at biochemical...
Summary Background/objective There is an increasing rate of papillary thyroid carcinomas that may never progress to cause symptoms or death. Predicting outcome and determining tumour aggressiveness could help diminish the number patients submitted aggressive treatments. We aimed evaluate whether markers immune system response tumour‐associated inflammation predict differentiated cancer ( DTC ) patients. Design Retrospective cohort study. Patients studied 399 consecutive patients, including...
Forkhead box P3 (FoxP3) expression has been observed in human cancer cells but not yet reported thyroid cells. We investigated the prognostic significance of both FoxP3 and intratumoral FoxP3(+) lymphocyte infiltration differentiated carcinoma cells.We constructed a tissue microarray with 385 tissues, including 266 malignant tissues (from 253 papillary carcinomas 13 follicular carcinomas), 114 benign lesions, 5 normal tissues.We determined tumor tumor-infiltrating lymphocytes using...
Os nódulos tireoidianos constituem a principal manifestação clínica de uma série doenças da tireóide com prevalência aproximadamente 10% na população adulta. O maior desafio é excluir o câncer tireóide, que ocorre em 5 dos casos. carcinomas diferenciados respondem por 90% casos todas as neoplasias malignas tireóide. A maioria pacientes carcinoma diferenciado apresenta, geralmente, um bom prognóstico quando tratada adequadamente, índices mortalidade similares à geral. No entanto, alguns...
Cooccurrences of chronic lymphocytic thyroiditis (CLT) and thyroid cancer (DTC) have been repeatedly reported. Both CLT DTC, mainly papillary carcinoma (PTC), share some epidemiological molecular features. In fact, inflammatory reaction has observed in association with PTC at variable frequency, although the precise relationship between two diseases is still debated. It also remains a matter debate whether or even an autoimmune disorder could influence prognosis PTC. A better understanding...
Conflicting data concerning the association between obesity and differentiated thyroid cancer (DTC) may be attributed to lack of records showing dietary intake inadequate evaluation nutrient composition. We evaluated 115 DTC patients carefully paired with 103 healthy control individuals by using a structured questionnaire, including 24-h recordatory during 3 days, investigate calorie macronutrient (proteins, carbohydrates, lipids) composition diet. observed that excess weight (body mass...
INTRODUÇÃO: O hipotireoidismo subclínico (HSC), definido por concentrações elevadas do TSH em face de níveis normais dos hormônios tireoidianos, tem elevada prevalência no Brasil, particularmente entre mulheres e idosos. Embora um número crescente estudos venha associando o HSC com maior risco doença arterial coronariana mortalidade, não há ensaio clínico randomizado sobre benefício tratamento levotiroxina na redução riscos permanece controverso. OBJETIVO: Este consenso, patrocinado pelo...