A5107968042- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Vitamin D Research Studies
- Infant Nutrition and Health
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Genetic Syndromes and Imprinting
- Autopsy Techniques and Outcomes
- Epigenetics and DNA Methylation
- Hearing, Cochlea, Tinnitus, Genetics
- Sympathectomy and Hyperhidrosis Treatments
- Salivary Gland Disorders and Functions
- Body Composition Measurement Techniques
- Hedgehog Signaling Pathway Studies
- Ion channel regulation and function
- Child Abuse and Related Trauma
- Adrenal and Paraganglionic Tumors
- Oral and Craniofacial Lesions
- Organ Donation and Transplantation
- Radiation Dose and Imaging
- Renal function and acid-base balance
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
1998-2024
Universidade de São Paulo
2002-2020
Instituto do Câncer do Estado de São Paulo
2020
Universidade Brasil
2008-2009
Instituto Adolfo Lutz
1989-1996
County Hospital
1992
The aims of these recommendations were to develop clinical guidelines for evaluation and management patients with differentiated thyroid cancer applicable Latin American countries. panel was composed by 13 members the Thyroid Society (LATS) involved research from different medical centers in America. produced on basis expert opinion use principles Evidence-Based Medicine. Following a group meeting, first draft based evidences opinions elaborated and, later, circulated among members, further...
The aim of this study was to explore the perceived sources stress reported by dental students from fourteen different countries.A total 3568 were recruited 14 schools. environmental (DES) questionnaire used including 7 domains. Responses DES scored in 4-point Likert scale. Comparison between performed according variables. top 5 stress-provoking questions identified amongst Data analysed using SPSS software program. Mann-Whitney and Kruskal-Wallis tests as appropriate. Logistic regression...
Objective To evaluate the prevalence of chronic autoimmune thyroiditis (CAT) and iodine-induced hypothyroidism, hyperthyroidism (overt subclinical), goiter in a population exposed to excessive iodine intake for 5 years (table salt concentrations: 40–100 mg/kg salt). Design This was population-based, cross-sectional study with 1085 participants randomly selected from metropolitan area São Paulo, Brazil, conducted during first semester 2004. Methods Thyroid ultrasound examination performed all...
Summary objective Patients with very large multinodular goitres, frequently found among elderly people, often suffering from cardiovascular or other disabling disorders, may be considered as unsuitable for surgery. We have evaluated the feasibility of relatively high‐dose 131 I therapy in such patients. As subclinical clinical hyperthyroidism is commonly these patients, associated a low radioiodine (RAI) uptake at 24 h, we pretreated group patients single intramuscular injection recombinant...
Objective: The objective of the study was to determine diagnostic accuracy 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) in preoperative diagnosis thyroid nodules with indeterminate fine-needle aspiration biopsy results.
Background: The morbidity of papillary thyroid carcinoma (PTC) is primarily related to locoregional recurrences and distant metastases. definition minimal extrathyroidal extension (mETE) has been recently revised. presence mETE does not impact mortality generally considered be a predictor for the risk recurrence. This study aimed at comparing recurrence response therapy PTC with gross (ETE) into strap muscles (gETE) low- intermediate-risk without ETE (low w/o intermediate ETE, respectively)...
Several guidelines on diagnosis and treatment of thyroid nodules cancer have recently been published. However, recommended practices are not always appropriate to different settings or countries. The aim this consensus was develop Clinical Guidelines for evaluation management patients with applicable Latin American panel composed by 13 members the Thyroid Society involved research from medical centers in America. produced based expert opinion use principles evidence-based medicine. Following...
In thyroid tumors, reduced radioiodine uptake is associated with worse patient outcome concomitantly low sodium/iodide symporter (NIS) mRNA expression. Previous studies showed that CpG-island methylation in the NIS proximal promoter does not correlate The aim of study was to identify new CpG-islands within 5′region and investigate involvement their DNA obtained from 30 pairs samples: tumor (T) surrounding nontumor (NT) samples. All T samples had expression compared NT Methylation degree...
Iodine deficiency during pregnancy is associated with obstetric and neonatal adverse outcomes. Serum thyroglobulin (sTg) thyroid volume (TV) are optional tools to urinary iodine concentration (UIC) for defining status. This cross-sectional study aims evaluate the status of pregnant women living in iodine-adequate area by spot UIC correlation sTg, TV function.Two hundred seventy-three were evaluated at three trimesters. All had no previous disease, supplementation negative thyroperoxidase...
To evaluate the prevalence of chronic autoimmune thyroiditis in 2 urban areas metropolitan São Paulo (Brazil): Polo Area neighboring a large petrochemical complex and Bernardo Campo (control area).Subjects were randomly included from adult population (20 to 70 years age) both genders (women 80%, men 20%) who voluntarily agreed participate. From Area, vicinity industrial complex, 409 subjects included; control area (São Area) 420 individuals included. All clinically examined, detailed record...
Total thyroidectomy, radioiodine (RAI) therapy, and TSH suppression are the mainstay treatment for differentiated thyroid carcinomas (DTCs). Treatments metastatic disease include surgery, external-beam radiotherapy, RAI, kinase inhibitors progressive iodine-refractory disease. Unresectable locoregional remains a challenge, as standard therapy with RAI becomes unfeasible. We report case of young patient who presented unresectable papillary carcinoma (PTC), sorafenib allowed total...
In this article we describe detailed pathological and molecular genetics studies in a consanguineous kindred with Pendred's syndrome. The index patient was 53-year-old female congenital deafness goiter. Her parents were first-degree cousins. She had large goiter (150 g) that been present since childhood. One of her sisters niece are also deaf have as well. presence syndrome confirmed by positive perchlorate test the demonstration Mondini malformation. Thyroid function tests (under...
A iodação do sal é eficiente no combate às doenças decorrentes da deficiência de iodo, sendo empregada em todo território nacional desde 1995. O Estado São Paulo considerado uma área ioda-suficiente. Para avaliar a ingesta foram selecionados aleatoriamente 844 escolares entre 6 e 14 anos, seis regiões Estado. Foram avaliados, sob o ponto vista ecográfico tireóide, 423 meninos 421 meninas. Os volumes glândula tireóide elevaram-se progressivamente com idade, guardando correlação positiva...
The expression of sodium iodide symporter (NIS) is required for uptake in thyroid cells. Benign and malignant tumors have low uptake. However, previous studies by RT-PCR or immunohistochemistry shown divergent results NIS these nodules.The objective the study was to investigate mRNA transcript levels, compare with TSH receptor proteins expression, localize protein nodules samples their surrounding nonnodular tissues (controls).NIS quantified real-time RT-PCR, proteins, evaluated...
High nutritional levels of iodine may induce a higher prevalence autoimmune thyroiditis, hypothyroidism, goiter, as well hyperthyroidism, mostly in the elderly. This study assessed thyroid volume and ultrasonographic abnormalities urinary excretion (UIE) 964 schoolchildren living an iodine-sufficient area southern Brazil. Thyroid correlated with age body surface boys girls. In 76.8% children, UIE was above 300 microg/l, among compared to girls (484.2 microg/l vs 435.3 p < 0.001). detected by...
Our objective was to establish thyroid volume by sonography in Brazilian schoolchildren and correlate with anthropometric characteristics.Sonographic studies of were conducted 1,977 (6-14 years old) from 21 villages towns Central Brazil. Iodine concentration analyzed urine specimens salt samples obtained the children's homes. Thyroid volumes also compared reported for other countries.Age, height, weight correlated volume. boys girls generally lower than those Europe comparable Malaysia Iran....
To evaluate the prevalence of thyroid dysfunction in elderly cardiac patients an outpatient setting. A total 399 consecutive (268 women, age range 60–92 years) who were followed at Heart Institute evaluated for with serum free T4, TSH, anti-Peroxidase antibodies, urinary iodine excretion measurements and ultrasound. Hyperthyroidism (overt subclinical) was present 29 (6.5%), whereas hypothyroidism found 32 individuals (8.1%). Cysts detected 11 (2.8%), single nodules 102 (25.6%), multinodular...
Treatment of multinodular goiters (MNGs) is highly controversial. Radioiodine (RAI) therapy a nonsurgical alternative for the elderly who decline surgery. Recently, recombinant human thyrotropin (rhTSH) has been used to augment RAI uptake and distribution. In this study, we determined outcome 30 mCi preceded by rhTSH (0.1 mg) in euthyroid (EU) hyperthyroid (subclinical/clinical) patients with large MNGs.This was prospective cohort study. Forty-two (age, 43-80 years) MNGs were treated after...
Objective Hürthle cell carcinomas (HCCs) of the thyroid have been recently reclassified as a separate entity due to their distinct clinical and molecular profiles. Few studies assessed ability preoperative characteristics in differentiating HCCs from adenomas (HCAs) low prevalence both lesions. This study aimed compare features HCAs evaluate diagnostic performance ultrasound distinguishing between both. Subjetcs methods Retrospective including 101 patients (52 49 HCAs) who underwent surgery...
Struma ovarii is an infrequent ovarian tumor, and there are only few reports with detailed data of thyroid function. In several cases, malignant struma have been shown to produce hyperthyroidism, but no reported case hypothyroidism following tumor resection. A 62-year-old white woman underwent right ovary resection that had a pathologic diagnosis ovarii. After 6 days, she developed weakness, myalgia, somnolence, nausea, arterial hypotension. Laboratory tests showed high level...
O objetivo deste estudo foi avaliar a nossa classificação ultra-sonográfica dos nódulos tireóideos, baseada na ecoestrutura, ecogenicidade, calcificação, contornos e análise do restante parênquima. De janeiro de 1998 2002, 2468 pacientes portadores tireóideos foram encaminhados ao nosso serviço para realização ultra-sonografia punção aspirativa por agulha fina guiada pelo ultra-som (US-PAAF). 1039 considerados benignos ultra-som, 998 (96,05%) também apresentaram citologia benigna, 37 (3,6%)...