A5044682184- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Vitamin D Research Studies
- BRCA gene mutations in cancer
- Head and Neck Anomalies
- Ophthalmology and Eye Disorders
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Ion channel regulation and function
- High Altitude and Hypoxia
- Regulation of Appetite and Obesity
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Diet and metabolism studies
- Lipid metabolism and disorders
- Adrenal Hormones and Disorders
- Sexual Differentiation and Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Estrogen and related hormone effects
Universidade Federal do Rio de Janeiro
2015-2024
Universidade Federal do Estado do Rio de Janeiro
2024
Universidade Federal de Minas Gerais
2023
Hospital Universitário Clementino Fraga Filho
2013-2022
Instituto Nacional do Câncer
2007-2021
Fundação Faculdade de Medicina
2010-2012
Universidade do Estado do Rio de Janeiro
2003-2011
Rigshospitalet
2011
Copenhagen University Hospital
2011
Endocrinology Research Center
2010
Summary Objective To validate the A merican T hyroid ssociation ( ATA ) initial risk of recurrence scheme and M emorial S loan K ettering C ancer enter MSKCC response to therapy re‐stratification approach in a large cohort patients with differentiated thyroid cancer DTC treated outside U nited tates. Design Retrospective chart review. Patients Five hundred six followed for median 10 years after total thyroidectomy RAI remnant ablation at major centre B razil. Measurements Final clinical...
Although response to therapy assessment is a validated tool for dynamic risk stratification in patients with differentiated thyroid cancer (DTC) treated total thyroidectomy (TT) and radioactive iodine (RAI), it has not been well studied lobectomy or TT without RAI. Because these responses definitions are heavily dependent on serum thyroglobulin (Tg) levels, modifications of the original were needed appropriately classify RAI.This study aimed validate DTC was retrospective study, which took...
Age is a critical factor in outcome for patients with well-differentiated thyroid cancer. Currently, age 45 years used as cutoff staging, although there increasing evidence to suggest this may be too low. The aim of study was assess the potential changing cut point American Joint Committee on Cancer/Union International Cancer Control (AJCC/UICC) staging system from 55 based combined international patient cohort supplied by individual institutions.
Background: In most staging systems, 45 years of age is used to differentiate low risk thyroid cancer from high cancer. However, recent studies have questioned both the precise year point and concept using a binary cut off as accurate predictors disease specific mortality. Methods: A cohort 3664 patients that received surgery adjuvant treatment at Memorial Sloan Kettering Cancer Center (MSKCC) 1985 2010 were analyzed determine significance diagnosis categorical variable variety cutoffs (5...
The aims of these recommendations were to develop clinical guidelines for evaluation and management patients with differentiated thyroid cancer applicable Latin American countries. panel was composed by 13 members the Thyroid Society (LATS) involved research from different medical centers in America. produced on basis expert opinion use principles Evidence-Based Medicine. Following a group meeting, first draft based evidences opinions elaborated and, later, circulated among members, further...
Hypothyroidism has long been known for its effects on different organ systems, leading to hypometabolism. However, subclinical hypothyroidism, most prevalent form, recently related cardiovascular risk and also maternal-fetal complications in pregnant women.In these clinical practice guidelines, several aspects of this field have discussed with the clear objectives helping physicians treat patients sharing some our Latin American-based experience.The American Thyroid Society commissioned a...
Introduction Neutrophils play a major role in sepsis-induced organ dysfunction, especially the lung.HMGB1 has emerged as late cytokine and is implicated perpetuation of inflammatory stimulus dysfunction development well.There are limited data about neutrophil response patterns to HMGB1 septic patients, whether those could be different from following LPS exposure.Objectives To evaluate differences gene expression activation NF-κB, Akt, p38MAPK blood neutrophils patients exposed LPS; compare...
Thyroid cancer in children and adolescents is usually a major concern for physicians, patients, parents. Controversies regarding the aggressiveness of clinical presentation ideal therapeutic approach remain among scientific community. The current recommendations staging systems are based on data generated by studies adults, this might lead to overtreating some cases as well undertreating others. Understanding differences biology, course, outcomes population crucial decisions. This paper...
Objective African-Americans have been shown to low prevalence of hypothyroidism. Brazil has a high ethnic admixture allowing further exploration into whether environmental factors can explain the differences. Design A survey, representative population Rio de Janeiro, large metropolitan city in Brazil. Factors studied included race, parity, income, schooling, and smoking. Population The survey was carried out Janeiro whereby households (1500) were selected using three-stage probability...
Background and Objective . An individualized risk-based approach to the treatment of thyroid cancer is being extensively discussed in recent literature. However, controversies about ideal surgical remain an important issue with regard impact on prognosis follow-up strategies. This study was designed describe clinical outcomes a cohort low intermediate risk patients treated lobectomy. Methods Retrospective review 70 who underwent Results After median 11 years, 5 (5/70, 7.1%) recurred had...
To evaluate the prevalence of goiter and nodular disease in patients with class III obesity, to correlate results serum leptin levels insulin resistance (IR) parameters.A cross-sectional study was performed assess thyroid ultrasound (US) patterns, HOMA-IR, leptin, TSH obese controls.Thyroid volume positively correlated body mass index (BMI) (r = 0.240, p 0.039) HOMA-IR 0.329; < 0.01). Thyroid US patterns were similar between groups. However, when data from male group considered, greater...
The incidence of pediatric differentiated thyroid carcinoma (DTC) has been rising in recent years, and the main risk factors for recurrence are lymph node distant metastasis at diagnosis. Other clinical features remain unclear, such as impact age, sex, puberty. Furthermore, until now, this population treated using same strategies used to treat adults. In 2015, American Thyroid Association (ATA) published first guidelines targeted age group. aims study were investigate prognostic early...
Objective: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks endurance training. Subjects and methods: In first phase, a cross-sectional study conducted which 22 sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26.2 (8.7) kg/m2, thyroid stimulating hormone > 4.94 mIU/L free thyroxine between 0.8 1.3 ng/dL were compared group 33 euthyroid concerned HRQoL. second randomized clinical trial where only...
The majority of somatotropinomas are sporadic, although a small number occur with familial aggregation, either as component an endocrine neoplasia complex that includes multiple type 1 (MEN-1) and Carney (CNC) or isolated (IFS). IFS is defined the occurrence at least two cases acromegaly gigantism in family does not exhibit MEN-1 CNC. This rare disease associated loss heterozygosity (LOH) on chromosome 11q13, locus gene, sequence expression appear normal. These data suggest presence another...
Os nódulos tireoidianos constituem a principal manifestação clínica de uma série doenças da tireóide com prevalência aproximadamente 10% na população adulta. O maior desafio é excluir o câncer tireóide, que ocorre em 5 dos casos. carcinomas diferenciados respondem por 90% casos todas as neoplasias malignas tireóide. A maioria pacientes carcinoma diferenciado apresenta, geralmente, um bom prognóstico quando tratada adequadamente, índices mortalidade similares à geral. No entanto, alguns...
Phosphoinositide-3-kinase (PI3K) inhibition increases functional sodium iodide symporter (NIS) expression in both FRTL-5 rat thyroid cell line and papillary cancer lineages. In several types, the stimulation of PI3K results downstream activation mechanistic target rapamycin (MTOR), a serine–threonine protein kinase that is critical regulator cellular metabolism, growth, proliferation. MTOR involved regulation thyrocyte proliferation by TSH. Here, we show uptake TSH-stimulated PCCL3 line,...
Recombinant human TSH (rhTSH) can be used to enhance (131)I therapy for shrinkage of multinodular goiter (MG).The objective the study was compare efficacy and safety 0.01 0.03 mg modified-release (MR) rhTSH as an adjuvant therapy, vs. alone, in a randomized, placebo-controlled, international, multicenter study.Ninety-five patients (57.2 ± 9.6 yr old, 85% females, 83% Caucasians) with MG (median size 96.0, range 31.9-242.2 ml) were randomized receive placebo (group A, n = 32), MRrhTSH B, 30),...