A5085750703- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Ovarian cancer diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- PARP inhibition in cancer therapy
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- DNA Repair Mechanisms
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Liver physiology and pathology
Renji Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
Zhejiang Chinese Medical University
2025
Chongqing Medical University
2022-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2025
Shenzhen Children's Hospital
2025
Chongqing Municipal Health Commission
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Beijing Technology and Business University
2024
Henan University
2024
Proper cell models for breast cancer primary tumors have long been the focal point in cancer's research. The genomic comparison between lines and can investigate similarity dissimilarity help to select right model mimic tumor tissues properly evaluate drug reaction vitro. In this paper, a comprehensive copy number variation (CNV), mutation, mRNA expression protein 68 1375 is conducted presented. Using whole genome arrays, strong correlations were observed cells tumors. PAM50 gene...
High-grade serous ovarian cancer (HGSOC) is hallmarked by early onset of peritoneal dissemination, which distinguishes it from low-grade (LGSOC). Here, we describe the aggressive nature HGSOC ascitic tumor cells (ATCs) characterized integrin α5high (ITGA5high) ATCs, are prone to forming heterotypic spheroids with fibroblasts. We term these aggregates as metastatic units (MUs) in for their advantageous capacity and active involvement dissemination. Intriguingly, fibroblasts inside MUs support...
Cancer-associated fibroblasts (CAFs) play a key role in the cancer process, but research progress is hampered by paucity of preclinical models that are essential for mechanistic dissection cell-CAF interactions. Here, we aimed to establish 3-dimensional (3D) organotypic co-cultures primary liver tumor-derived organoids with CAFs, and understand their interactions response treatment.Liver tumor CAFs were cultured from murine human tumors. 3D co-culture Transwell culture systems established...
Background Several environmental agents termed "endocrine disrupting compounds" or EDCs have been reported to bind and activate the estrogen receptor-α (ER). The DDT BPA are ubiquitously present in environment, levels human blood adipose tissue detectable most if not all women men. ER-mediated biological responses can be regulated at numerous levels, including expression of coding RNAs (mRNAs) more recently non-coding (ncRNAs). Of ncRNAs, microRNAs emerged as a target signaling. Given...
Physiological repair of large-sized bone defects is great challenging in clinic due to a lack ideal grafts suitable for regeneration. Decalcified matrix (DBM) considered as an regeneration scaffold, but low cell seeding efficiency and poor osteoinductive microenvironment greatly restrict its application To address these problems, we proposed novel strategy units (BRUs) based on microgels produced by photo-crosslinkable microfluidic techniques, containing both the osteogenic ingredient DBM...
Poly(ADP-ribosyl)ation by poly(ADP-ribose) polymerases regulates the interaction of many DNA damage and repair factors with sites strand lesions. The these (PAR) is mediated specific domains, including recently identified PAR-binding zinc finger (PBZ) domain. However, mechanism governing interactions unclear. To better understand PBZ-PAR interaction, we performed a detailed examination representative PBZ-containing protein involved in response, aprataxin polynucleotide-kinase-like factor...
Whole genome transcriptomic analyses have identified a large number of long non-coding RNAs (lncRNAs), many which are involved in variety biological functions. However, their functions and molecular mechanisms associated with prostate cancer (PCa) progression to virulent androgen-independent (AI) form remain elusive. Herein, we investigated the lncRNA expression profiles indolent, androgen-dependent (AD) LNCaP cell line aggressive metastatic, AI C4-2 using microarray technology. The...
Abstract Purpose: Previous poor results of liver transplantation (LT) have been confirmed in patients with advanced hepatocellular carcinoma (HCC). Adenovirus-mediated delivery herpes simplex virus thymidine kinase (ADV-TK) therapy is an established adjuvant treatment cancer, and we evaluated its potential as for HCC who underwent LT. Experimental Design: Forty-five tumors >5 cm diameter participated the study over a follow-up period 50 months. Among these patients, 22 received LT...
APLF is a forkhead associated-containing protein with poly(ADP-ribose)-binding zinc finger (PBZ) domains, which undergoes ionizing radiation (IR)-induced and Ataxia-Telangiectasia Mutated (ATM)-dependent phosphorylation at serine-116 (Ser116). Here, we demonstrate that the of Ser116 in human U2OS cells by ATM dependent on poly(ADP-ribose) polymerase 3 (PARP3) levels PBZ domains. The interaction sites DNA damage was diminished single substitution to alanine, cellular depletion or chemical...
Abstract Cancer-associated fibroblasts (CAFs) are common components of the tumor-suppressive microenvironment and a major determinant poor outcome therapeutic vaccination. In this study, we modified tumor cells to express fibroblast activation protein (FAP), which is highly expressed by CAFs, potentially improve whole-cell vaccines targeting both CAFs. Tumor were transfected with murine FAP plasmids bearing cationic lipid DOTAP. Its antitumor effects investigated in three established models....
The chemokine receptor 4 (CXCR4) plays an important role in the growth, angiogenesis and metastasis of various cancers, including epithelial ovarian cancer (EOC). However, correlation between CXCR4 clinical response EOC patients to chemotherapy remains unknown. 124 were recruited assess relationship cisplatin-based chemotherapy. results showed that with a higher expression had significantly lower chemosensitivity, poorer progression-free survival overall than those expression. In addition,...
// Meng Li 1,2,* , Sirui Fu 3,* Yanjie Zhu 4 Zaiyi Liu 2 Shuting Chen Ligong Lu 3 and Changhong Liang 1 Southern Medical University, Guangzhou, China Department of Radiology, Guangdong General Hospital, Academy Sciences, Interventional Oncology, Provincial Cardiovascular Institute, Shenzhen Institutes Advanced Technology, Shenzhen, * These authors have contributed equally to this manuscript Correspondence to: Lu, email: Liang, Keywords : hepatocellular carcinoma, texture analysis, computed...
Abstract Endometrial cancer (EC) is the sixth most common in women. Since early EC has a good prognosis, identifying methods for diagnosis valuable. Here, we aimed to study role of HDAC6, which been indicated important many kinds cancers, and therapy. First, expression levels HDAC6 tissues cells were measured by qRT-PCR Western blotting, through bioinformatics dual luciferase assays, was found be direct target miR-206. Then, CCK-8, colony formation, wound healing, Transwell assays performed;...
Triple-negative breast cancer (TNBC), as a highly aggressive and metastatic tumor, can still not contain the medical needs. It has become an urgent problem to develop prognostic markers further realize precision medicine. The predictive significance of peripheral blood lymphocytes, well clinicopathological factors affecting them, were explored in present study.The data 278 patients with TNBC collected analyzed retrospectively. Peripheral lymphocytes (pBL) routine indexes before treatment...
Introduction Recently, immune cells within the tumor microenvironment (TME) have become crucial in regulating cancer progression and treatment responses. The dynamic interactions between tumors are emerging as a promising strategy to activate host's system against various cancers. development of hepatocellular carcinoma (HCC) involve complex biological processes, with role TME phenotypes still not fully understood. Therefore, it is essential investigate importance cell homeostasis HCC....
Abstract The extensive intercellular material and information flow in the immune microenvironment is instructive to development of targeted delivery strategies, but has received little attention previously. In this study, efferocytosis, an important link during inflammation, creatively used achieve a significant increase efficiency. A tailored “neutrophil airfreighter” strategy developed deliver plenty siRNA‐loaded nanocomplexes (FCM@siNPs) mtDNA‐releasing sentinel mononuclear phagocytes...
Endothelial barrier disruption exacerbates inflammation and tissue injury, posing dual challenges of reconstructing tight junctions precisely regulating the local microenvironment. Traditional multidrug therapies often struggle with rapid drug leakage due to dysfunction limited synergy between therapeutic agents. Here, a strategy is proposed inspired by "ant colony collaboration", developing an "all-in-one" conformationally adaptive peptide nanoregulator (VJP NPs) through intelligent...
Abstract Papillary thyroid cancer (PTC) is one of the most common endocrine malignancies associated with significant morbidity and mortality. Although multiple studies have contributed to a better understanding genetic alterations underlying this frequently arising disease, downstream molecular effectors that impact PTC pathogenesis remain be further defined. Here, we report regulator cell fate specification, PROX1, becomes inactivated in through mRNA downregulation cytoplasmic...