A5100338856- Automotive and Human Injury Biomechanics
- Healthcare and Venom Research
- Spine and Intervertebral Disc Pathology
- Ferroptosis and cancer prognosis
- COVID-19 Impact on Reproduction
- Spinal Fractures and Fixation Techniques
- Geological and Geochemical Analysis
- SARS-CoV-2 and COVID-19 Research
- Toxin Mechanisms and Immunotoxins
- Immune cells in cancer
- Phytochemistry and Biological Activities
- PARP inhibition in cancer therapy
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Acupuncture Treatment Research Studies
- Phytochemistry and Bioactivity Studies
- Phagocytosis and Immune Regulation
- Colorectal Cancer Treatments and Studies
- Geochemistry and Elemental Analysis
- Thermal properties of materials
- Autophagy in Disease and Therapy
- Gout, Hyperuricemia, Uric Acid
- Medicinal Plants and Bioactive Compounds
Xian Central Hospital
2025
Beijing University of Chinese Medicine
2025
Soochow University
2025
First Affiliated Hospital of Anhui Medical University
2024
Second Military Medical University
2023
First Hospital of Jilin University
2023
Jilin University
2023
Shandong University of Traditional Chinese Medicine
2022
China Geological Survey
2022
China University of Geosciences (Beijing)
2022
Abstract T cells engineered to express chimeric antigen receptors (CARs) with specificity toward tumor have led promising outcomes in patients hematological malignancies. Nevertheless, the application of CAR‐T cell therapy solid tumors encounters several obstacles. These include heterogeneity and immune escape, exhaustion restricted infiltration into that affect therapeutic efficacy cells, as well “on‐target, off‐tumor” toxicities can lead severe even fatal adverse events. In recent years,...
Poly(ADP-ribosyl)ation by poly(ADP-ribose) polymerases regulates the interaction of many DNA damage and repair factors with sites strand lesions. The these (PAR) is mediated specific domains, including recently identified PAR-binding zinc finger (PBZ) domain. However, mechanism governing interactions unclear. To better understand PBZ-PAR interaction, we performed a detailed examination representative PBZ-containing protein involved in response, aprataxin polynucleotide-kinase-like factor...
Clostridium perfringens can induce necrotic enteritis of chickens, which causes large economic losses every year. Bacillus licheniformis, a probiotic, inhibit the growth pathogenic bacteria such as perfringens, thereby improving health status chickens. However, from microbial ecology perspective, mechanisms by alterations to gut microbiota improve remain unknown. In this study, we used Illumina MiSeq sequencing investigate cecal negative control group (NC), C. and Eimeria challenge with...
Although a number of finite element (FE) adult cervical spine models have been developed to understand the injury mechanisms neck in automotive related crash scenarios, there fewer efforts develop child model. In this study, 10-year-old ligamentous FE model was for application improvement pediatric safety motor vehicle crashes. The geometry obtained from medical scans and meshed using multi-block approach. Appropriate properties based on review literature conjunction with scaling were...
Since December 2019, the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first spread quickly in Wuhan, China, then globally. Based on previously published evidence, ACE2 and TMPRSS2 are both pivotal entry molecules that enable cellular infection by SARS-CoV-2. Also, increased expression of pro-inflammatory cytokines, or a "cytokine storm," is associated with multiple organ dysfunction often observed critically ill patients.We investigated pattern major...
Previous research has suggested a link between gut microbiota and attention deficit hyperactivity disorder (ADHD), but their causal relationship not been elucidated. Aiming to comprehensively investigate identify specific microbe taxa for ADHD, we conducted two-sample Mendelian randomization (MR) analysis. Instrumental variables of 211 were obtained from gene wide association study (GWAS), was carried out estimate effects on ADHD risk PGC GWAS (20,183 cases 35,191 controls) FinnGen (830...
Abstract Sepsis can cause septic shock, multiple organ dysfunction and even death. The combination of different blood purification would be the certain trend in treatment sepsis. This study was to evaluate clinical effects hemoperfusion (HP) combined with pulse high volume hemofiltration (PHVHF) on shock. Thirty cases were involved this randomly divided into two groups: HP PHVHF group (n = 15) CVVH (continuous veno-venous hemofiltration) 15). Acute physiology chronic health evaluation...
Interleukin-2 receptor β (IL2RB) is a protein of interleukin-2. IL2RB implicated in regulation T cell-mediated immune response. However, the role pan-cancer unknown. The present premise sought to explore tumorigenesis, tumor metabolism, and immunity pan-cancer.Data were retrieved from multiple data resources including GTEx resource, CCLE TCGA UCSC TISIDB web server. These adopted assess expression, prognosis value, relationship between microenvironment, microsatellite instability, new...
A novel ent-labdane type diterpenoid, muscicolone (1), as well two bibenzyls (2, 3) and four flavonoids (4-7) were isolated from the liverwort Frullania muscicola Steph. Their structures established by analysis of spectral data IR, UV, ID-, 2D-NMR, ORD. The stereostructure 1 was confirmed X-ray crystallographic analysis. Bioassay experiments showed that compound 3 4 have potent inhibitory effects against some fungi while cytotoxic to human tumor cells.
Poly ADP ribose polymerase (PARP) inhibitors are mainly used in treating BRCA-mutant cancers, and their application novel therapies to expand benefit is of interest personalized medicine.A recent report showed that pharmacological targeting PARP increases the sensitivity cancer cells EGFR inhibition, but therapeutic value this combination has not been fully determined.We propose a strategy combining with bispecific antibodies target both Notch signalling, highlighting difficulties posed by...
Abstract Background Since December 2019, the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first spread quickly in Wuhan, China, then globally. From previously published evidence, ACE2 and TMPRSS2, are both pivotal entry molecules that enable cellular infection by SARS-CoV-2. Meanwhile, increased expression of pro-inflammatory cytokines, or a “cytokine storm,” is associated with multiple organ dysfunction often observed critically ill patients. Methods We...
To investigate the effect of a seashell protein Haishengsu (HSS), an extract from shellfish Tegillarca granosa, on cell growth and expression apoptosis genes in leukemia K562 cells.Cultured cells were treated with HSS at various concentrations (10-40 mg/L). The cycle, suppressor gene bcl-2 promoting bax evaluated.HSS, 20mg/L, inhibited cycle G0/G1 S phases. HSS, also over time. Expression 20mg/L (58.8%+/-4.7%) 40 mg/L group (26.6%+/-2.1%) lower than control (91.0+/-8.7%, P < 0.01)....
Herbal formulae have a long history in clinical medicine Asia. While the complexity of leads to complex compound-target interactions and resultant multi-target therapeutic effects, it is difficult elucidate molecular/therapeutic mechanism action for many formulae. For example, Hua-Yu-Qiang-Shen-Tong-Bi-Fang (TBF), an herbal formula Chinese medicine, has been used treating rheumatoid arthritis. However, target information great number compounds from TBF missing. In this study, we predicted...
The progression of liver fibrosis in chronic hepatitis B (CHB) patients is currently insufficiently controlled worldwide. Yi Guan Jian decoction (YGJD) has been widely used the treatment CHB cases. Although animal studies have reported antifibrotic effects decoction, active ingredients YGJD remain unknown. This study aimed at identifying potential and exploring mechanisms action (MOA) when treating with fibrosis.Using data mining techniques a structural clustering analysis, were determined....
Pediatric necks present different responses and injury patterns compared with those of adults in motor vehicle crashes (MVCs). To evaluate the effect muscle modeling methodologies, three models were developed simulated under low-speed frontal impact conditions an average peak acceleration 3g's. The activation curve for curve-guided model, segment was curved using guiding nodes, further optimized based on experimental data. pediatric neck model also more severe 8g's. Simulation results...
Autophagy was a significant catabolic process which played critical role in the maintenance of cellular homeostasis and viability stressed state. The dysregulation autophagy correlated with various diseases. aim our study to develop prognostic signature for papillary renal cell carcinoma (RCC).First, 40 differently expressed genes related (ARGs) were examined via high-throughput sequencing large-scale databases. Then, functional enrichment analysis performed explore biological attributes...