A5005716761- Cancer Treatment and Pharmacology
- Multiple Myeloma Research and Treatments
- HER2/EGFR in Cancer Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Glycation End Products research
- Caveolin-1 and cellular processes
- Flavonoids in Medical Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heat shock proteins research
- Nitric Oxide and Endothelin Effects
- Iron Metabolism and Disorders
- Acute Myeloid Leukemia Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lipid metabolism and disorders
- Histone Deacetylase Inhibitors Research
- Vitamin D Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammatory mediators and NSAID effects
- Metabolism, Diabetes, and Cancer
- Birth, Development, and Health
- Retinal Diseases and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Pain Mechanisms and Treatments
Women's Hospital, School of Medicine, Zhejiang University
2024-2025
Nanjing University of Chinese Medicine
2025
Nanjing Jiangning Hospital
2023
Hankou University
2023
Nanjing Medical University
2020-2023
Qingdao University
2023
Qingdao Municipal Hospital
2023
Tsinghua University
2023
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe dose-limiting side effect of chemotherapy and remains huge clinical challenge. Here, we explore the role microcirculation hypoxia induced by neutrophil extracellular traps (NETs) in development CIPN look for potential treatment.The expression NETs plasma dorsal root ganglion (DRG) are examined ELISA, IHC, IF Western blotting. IVIS Spectrum imaging Laser Doppler Flow Metry applied to CIPN. Stroke Homing peptide (SHp)-guided...
Oxaliplatin is an antineoplastic agent frequently used in the treatment of gastrointestinal tumors. However, it causes dose-limiting sensorimotor neuropathy, referred to as oxaliplatin-induced peripheral neuropathy (OIPN), for which there no effective treatment. Here, we report that elevation neutrophil extracellular traps (NET) a pathologic change common both cancer patients treated with oxaliplatin and murine model OIPN. Mechanistically, found NETs trigger NLR family pyrin domain...
To date, there remains a paucity of prospective studies examining the association between premature ovarian insufficiency (POI) and cardiovascular diseases (CVD). The objective this study was to investigate potential POI CVD utilizing method Mendelian randomization (MR). MR analyses utilized summary statistics from most extensive genome-wide (GWAS) on extracted European ancestry cohorts FinnGen biobank. inverse variance-weighted (IVW) primary analysis technique. Supplementary were performed...
Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and leading cause vision impairment in diabetic patients. The accumulation apoptotic cells inflammation are key pathological mechanisms DR. Mer tyrosine kinase (MerTK) receptor plays critical role maintaining retinal homeostasis. Proteolytic cleavage MerTK by disintegrin metalloproteinase-17 (ADAM17) disrupts MerTK-dependent clearance diminishes its anti-inflammatory effects. Therefore, reducing the activity...
Abstract Background Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of chemotherapy with poorly understood mechanisms and few treatments. High-mobility group box 1 (HMGB1)-induced neuroinflammation the main cause CIPN. Here, we aimed to illustrate role macrophage scavenger receptor A1 (SR-A1) in HMGB1 clearance CIPN resolution. Methods Oxaliplatin (L-OHP) was used establish model. Recombinant (rHMGB1) (his tag) evaluate phagocytosis by macrophages. Results In...
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by gold-standard analgesic morphine and other opioids. Endoplasmic reticulum (ER) stress has been shown to contribute neuropathic or inflammatory pain, but its roles opioids-induced (OIH) are elusive. Here, we provide first direct evidence that ER a significant driver of OIH. GRP78, marker, markedly upregulated neurons spinal cord after chronic treatment. At same time, induces activation three arms unfolded...
Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance morphine. High mobility group box-1 (HMGB1) has been shown participate neuropathic or inflammatory pain, but its role morphine is unclear. In this study, we established rat and mouse models of by intrathecal injection for 7 consecutive days. We found that induced spinal cord neurons release a large amount HMGB1. HMGB1 regulated nuclear factor κB p65 phosphorylation interleukin-1β...
BackgroundPrevious epidemiological studies have reported associations between vitamin D and postpartum depression (PPD); however, the findings are inconsistent. This study employs bidirectional Mendelian Randomization (MR) to investigate causal link serum 25-hydroxyvitamin [25(OH)D] levels PPD. By utilizing genetic data from cohorts, this research aims provide a more robust understanding of potential relationship PPD, addressing critical gap in current literature.MethodsA MR analysis was...
<p>Supplementary Figures 1-11</p>
Supplementary Figure from NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy
Supplementary Data from NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy
Supplementary Data from NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy
<p>Supplementary Figures 1-11</p>
Supplementary Figure from NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy
<div>Abstract<p>Oxaliplatin is an antineoplastic agent frequently used in the treatment of gastrointestinal tumors. However, it causes dose-limiting sensorimotor neuropathy, referred to as oxaliplatin-induced peripheral neuropathy (OIPN), for which there no effective treatment. Here, we report that elevation neutrophil extracellular traps (NET) a pathologic change common both cancer patients treated with oxaliplatin and murine model OIPN. Mechanistically, found NETs trigger NLR...
<div>Abstract<p>Oxaliplatin is an antineoplastic agent frequently used in the treatment of gastrointestinal tumors. However, it causes dose-limiting sensorimotor neuropathy, referred to as oxaliplatin-induced peripheral neuropathy (OIPN), for which there no effective treatment. Here, we report that elevation neutrophil extracellular traps (NET) a pathologic change common both cancer patients treated with oxaliplatin and murine model OIPN. Mechanistically, found NETs trigger NLR...
Acute myeloid leukemia (AML) is a blood cancer that diverse in terms of its molecular abnormalities and clinical outcomes. Iron homeostasis cell death pathways play crucial roles pathogenesis, including AML. The objective this study was to examine the significance genes involved iron-related apoptotic AML, with intention providing insights could have prognostic implications facilitate development targeted therapeutic interventions. Gene expression profiles, information, alterations were...
Abstract Background and objectives: A major unresolved issue in treating pain is the analgesic tolerance produced by opioids. Neuroinflammation was thought to be important development of morphine tolerance. The role High mobility group box-1 (HMGB1) elusive. Methods: ICR mice were used for tail-flick test evaluate SD rats collect CSF investigate whether could induce efflux HMGB1 into extracellular environment. neural cell line SH-SY5Y microglial BV-2 pharmacological effects mechanism...