A5064809801- Adenosine and Purinergic Signaling
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Peptidase Inhibition and Analysis
- Muscle Physiology and Disorders
- Selenium in Biological Systems
- Burn Injury Management and Outcomes
- Sulfur Compounds in Biology
- Neuroendocrine Tumor Research Advances
- Organoselenium and organotellurium chemistry
- Corneal Surgery and Treatments
- Disaster Response and Management
- COVID-19 Impact on Reproduction
- Chronic Myeloid Leukemia Treatments
- Pluripotent Stem Cells Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Eosinophilic Disorders and Syndromes
- Biomedical Ethics and Regulation
- COVID-19 Clinical Research Studies
Universidade Federal de Ciências da Saúde de Porto Alegre
2018-2025
University of Health Science
2019
Clinics Hospital of Ribeirão Preto
2017
Universidade de São Paulo
2017
Abstract Background ZEB1, a core transcription factor involved in epithelial-mesenchymal transition (EMT), is associated with aggressive cancer cell behavior, treatment resistance, and poor prognosis across various tumor types. Similarly, the expression activity of CD73, an ectonucleotidase implicated adenosine generation, important marker malignancy. Growing evidence suggests that EMT adenosinergic pathway are intricately linked play pivotal role development. Therefore, this study focuses...
Human Limbal (L-MSCs) and Dermal Mesenchymal Stem Cell (D-MSCs) possess many properties that increase their therapeutic potential in ophthalmology dermatology. It is known purinergic signaling plays a role aspects of mesenchymal stem cells physiology. They release respond to ligands, altering proliferation, migration, differentiation, apoptosis. Therefore, more information on these processes would be crucial for establishing future clinical applications using differentiation potential, but...
Abstract Adipose‐derived stromal/stem cells (ASCs) are promising candidates for cell‐based therapies. However, the lack of markers able to unequivocally identify these cells, differential expression cell surface molecules among stromal progenitors from different tissues and cellular alterations caused by culture phenomena that need be comprehensively addressed in order improve ASC purification consequently refine our knowledge about their function therapeutic efficiency. In this study, we...
Abstract Induced pluripotent stem cells (iPSCs) are reprogrammed with a remarkable capacity for unlimited expansion and differentiation into various cell types. Companies worldwide actively engaged in developing clinical-grade iPSC lines to address the needs of regenerative medicine, immunotherapies, precision medicine. However, ensuring safety quality iPSCs is essential, adherence Good Manufacturing Practices (GMP) ethical considerations being paramount. Perinatal tissue banks, such as...
Extracellular ATP (eATP) and its metabolites have emerged as key modulators of different diseases comprise a complex pathway called purinergic signaling. An increased number tools been developed to study the role nucleotides nucleosides in cell proliferation migration, influence on immune system tumor progression. These include receptor agonists/antagonists, engineered ectonucleotidases, interference RNAs ectonucleotidase inhibitors that allow control quantification nucleotide levels....
Amniotic membrane (AM) has been widely used as a biological dressing for many pathologies and illnesses worldwide, products derived from this tissue have commercially available in several countries. In Brazil, regulatory agencies recently authorized its clinical use non-experimental therapy burns, diabetic venous stasis ulcers, intrauterine adhesions. study, we present our pathway through validating the first service country of AM cryopreservation, with protocol long-term storage...
Our cord blood banking facility planned and executed a transferral of its entire operation to new site in the South Brazil. Transporting LN2 freezers is complex process which extensive planning essential minimize risks damaging products or storage units.To fulfill this objective, we constructed detailed relocation plan consisting four phases risk mitigation measures, collaborated with representatives all departments, regulating agencies, professionals from transport company, assembled...
Introduction: Glioblastoma is the most devastating form of brain tumor, characterized by an average survival 10 months. Standard therapy consists cytoreductive surgery followed radio and chemotherapy. Although therapeutic procedures are already well established, clinical practice has shown that extensive surgeries not related to increased patient rate. In addition, frequent recurrences seen due tumor infiltration cerebral parenchyma. Thus, it necessary establish new therapies increase...
Abstract Glioblastoma (GB) is the most common primary brain tumor, characterized by high aggressiveness and poor prognostic. Although all efforts, current therapy just palliative. Therefore, new biological targets are needed to treat this invasive cancer. In regard, immune modulation emerges as a possibility for cancer therapeutic. Literature has shown that purinergic system can regulate peripheral cell functions adenosine (ADO) plays an important role immunosuppressive molecule. CD73 enzyme...