A5017822272- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Antibiotic Use and Resistance
- Prostate Cancer Treatment and Research
- Cardiac, Anesthesia and Surgical Outcomes
- Homelessness and Social Issues
- RNA regulation and disease
- Meta-analysis and systematic reviews
- Prostate Cancer Diagnosis and Treatment
- Emergency and Acute Care Studies
- Chronic Disease Management Strategies
- Traffic and Road Safety
- Parvovirus B19 Infection Studies
- Parkinson's Disease Mechanisms and Treatments
- RNA modifications and cancer
- Epilepsy research and treatment
- Pneumonia and Respiratory Infections
- Intensive Care Unit Cognitive Disorders
- Clinical practice guidelines implementation
- Trauma and Emergency Care Studies
- Nursing Diagnosis and Documentation
- Folate and B Vitamins Research
Health Information and Quality Authority
2019-2025
Health and Safety Authority
2019-2024
USC Norris Comprehensive Cancer Center
2016-2024
King's College London
2023
University of Malaya
2023
University of Copenhagen
2023
Filadelfia
2023
Abiomed (United States)
2021
Royal College of Surgeons in Ireland
2009-2018
Health Research Board
2011
Objectives Our objective was to review the literature on inferred duration of infectious period COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, and provide an overview variation depending methodological approach. Design Rapid scoping review. Literature with fixed search terms, up 1 April 2020. Central tendency parameter estimates for in (A) asymptomatic (B) symptomatic cases from (1) virological studies (repeated testing), (2) tracing (3) modelling...
Both intracellular and extracellular heat shock protein-90 (Hsp90) family proteins (α β) have been shown to support tumour progression. The tumour-supporting activity of the Hsp90 is attributed their N-terminal ATPase-driven chaperone function. What molecular entity determines function secreted distinction between Hsp90α Hsp90β was unclear. Here we demonstrate that CRISPR/Case9 knocking out nullifies cells’ ability migrate, invade metastasize without affecting cell survival growth. Knocking...
Abstract Objective To estimate the proportion of pre-symptomatic transmission SARS-CoV-2 infection that can occur and timing relative to symptom onset. Setting/design Secondary analysis international published data. Data sources Meta-analysis COVID-19 incubation period a rapid systematic review serial interval generation time, which are separately. Participants Studies were selected for if they had transparent methods data provided enough information simulate full distributions or time....
Mutations in the genes encoding collagen VI (COL6A1, COL6A2, and COL6A3) cause Bethlem myopathy (BM) Ullrich congenital muscular dystrophy (UCMD), two related conditions of differing severity. BM is a relatively mild dominantly inherited disorder characterized by proximal weakness distal joint contractures. UCMD was originally regarded as an exclusively autosomal recessive condition causing severe muscle with contractures hyperlaxity. We others have subsequently modified this model when we...
Adult refugees and asylum seekers living in Western countries experience a high prevalence of mental health problems, especially post traumatic stress disorder (PTSD), depression anxiety. This study compares contrasts the potential risk factors as well utilisation services by Irish context.Cross sectional using validated self reported status questionnaires adult (n = 60) 28) from 30 countries, Ireland. Outcome measures included: general (SF-36), presence PTSD symptoms anxiety/depression...
Homeless populations experience poorer physical and mental health, more barriers to accessing adequate healthcare. This study investigates the health of this population, following provision a free access primary care service for homeless people in Dublin (Safetynet). The group will be compared previous studies on homelessness conducted prior establishment (in 1997 2005). Participants were recruited through Safetynet clinics. A 133-item questionnaire was administered determine participants’...
Abstract Objectives Our objective was to review the literature on inferred duration of infectious period COVID-19, caused by SARS-COV-2 virus, and provide an overview variation depending methodological approach. Design Rapid scoping review. Literature with fixed search terms, up 1 st April 2020. Central tendency parameter estimates for in (a) asymptomatic (b) symptomatic cases from ( i ) virological studies (repeated testing), ii tracing iii) modelling were gathered. Narrative viral...
<ns3:p>Background Correct staging and risk stratification is essential in ensuring prostate cancer patients are offered the most appropriate treatment. Interest has been growing use of radiotracers targeting specific membrane antigen (PSMA), including <ns3:sup>18</ns3:sup>F-PSMA PET-CT, as part primary or restaging cancer. Preliminary scoping identified a number relevant systematic reviews meta-analyses; however, individually, these each appear to look at only picture. An overview aims...
Objectives To determine the response of patients with different butyrylcholinesterase genotypes to therapy, and influence on cognition. Acetylcholine plays a key role in attention memory reduced cortical acetylcholine is associated severity dementia. Inhibitors enzyme acetylcholinesterase are an effective dementia treatment, though related less well understood. Methods We examined cohort enrolled trial cholinesterase inhibitor who had been genotyped at locus. Additionally prospectively...
Polymorphisms in folate-related genes have emerged as important risk factors a range of diseases including neural tube defects (NTDs), cancer, and coronary artery disease (CAD). Having previously identified polymorphism within the cytoplasmic folate enzyme, MTHFD1, maternal factor for NTDs, we considered more recently mitochondrial paralogue, MTHFD1L, candidate gene NTD association. We common deletion/insertion polymorphism, rs3832406, c.781-6823ATT(7-9), which influences splicing efficiency...
Dementia with Lewy bodies (DLB) represents the second commonest cause of dementia in elderly following Alzheimer’s disease (AD). Whilst presence is essential, DLB shares AD senile plaques (SP), but neurofibrillary tangles (NFT) are not a necessary feature. The apolipoprotein E (APO E) &#917;4 allele most consistently associated genetic risk factor for and has also been shown to associate DLB. We have therefore analysed APO large series cases coming autopsy to: (1) determine if describes...
Treatment of multidrug- and rifampin-resistant tuberculosis (MDR/RR-TB) is expensive, labour-intensive, associated with substantial adverse events poor outcomes. While most MDR/RR-TB patients do not receive treatment, many who are treated for 18 months or more. A shorter all-oral regimen currently recommended only a sub-set MDR/RR-TB. Its use conditionally because very low-quality evidence underpinning the recommendation. Novel combinations newer repurposed drugs bring hope in fight against...
Human dihydrofolate reductase (DHFR) was previously thought to be the only enzyme capable of reduction tetrahydrofolate; an essential reaction necessary ensure a continuous supply biologically active folate. DHFR has been studied extensively from number perspectives because its role in health and disease. Although presence intronless pseudogenes known since 1980s, it assumed that none these were expressed or functional. We show humans do have second encoded by former pseudogene DHFRP4 ,...