A5100664592- Genetics, Aging, and Longevity in Model Organisms
- Insect and Pesticide Research
- Circadian rhythm and melatonin
- Advanced Chemical Sensor Technologies
- Heat shock proteins research
- Healthcare and Venom Research
- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Cardiac Ischemia and Reperfusion
- Vibrio bacteria research studies
- Particle Dynamics in Fluid Flows
- Research on scale insects
- Tissue Engineering and Regenerative Medicine
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Hymenoptera taxonomy and phylogeny
- Receptor Mechanisms and Signaling
- RNA modifications and cancer
- Exercise and Physiological Responses
- Nonlinear Optical Materials Studies
- Education and Social Development in Ukraine
- Urinary Tract Infections Management
- Algal biology and biofuel production
- Photonic Crystals and Applications
- Phase-change materials and chalcogenides
California Institute of Technology
2021-2024
Southern Medical University
2014-2023
Nanfang Hospital
2017-2023
Harbin Engineering University
2023
Capital Medical University
2020
Beijing Chao-Yang Hospital
2020
Southern University of Science and Technology
2019
Cell Technology (China)
2019
Hong Kong University of Science and Technology
2019
University of Hong Kong
2019
Bacteria can swim upstream in a narrow tube and pose clinical threat of urinary tract infection to patients implanted with catheters. Coatings structured surfaces have been proposed repel bacteria, but no such approach thoroughly addresses the contamination problem Here, on basis physical mechanism swimming, we propose novel geometric design, optimized by an artificial intelligence model. Using
Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), among other illnesses. Of the ARD genotypes, HAdV-7 presents with more severe morbidity and higher mortality than others. We report isolation identification of a genome type HAdV-7d (DG01_2011) from recent outbreak in Southern China. Genome sequencing, phylogenetic analysis restriction endonuclease (REA) comparisons past indicate has re-emerged China after an absence twenty-one years....
The disruption and hyperpermeability of bronchial epithelial barrier are closely related to the pathogenesis asthma. House dust mite (HDM), one most important allergens, could increase airway permeability. Heat shock protein (Hsp) 90α is also implicated in lung endothelial dysfunction by disrupting RhoA signaling. However, effect extracellular Hsp90α (eHsp90α) on induced HDM has never been reported.To investigate involvement eHsp90α HDM, normal human cell line 16HBE14o- (16HBE) cells were...
Abstract Background The dysfunction of airway epithelial barrier is closely related to the pathogenesis asthma. Secreted Hsp90α participates in inflammation and Hsp90 inhibitor protects endothelial dysfunction. In current study, we aimed explore role secreted asthmatic function. Methods Male BALB/c mice were sensitized challenged with HDM generate asthma model. 16HBE Hsp90α-knockdown cells cultured treated according experiment requirements. Transepithelial Electric Resistance (TEER)...
Objective: GW4869 is an exosomal inhibitor. It necessary to delay the occurrence of gefitinib resistance during non-small-cell lung cancer (NSCLC) treatment. This study aimed investigate anti-tumor effects on epithelial-mesenchymal transition (EMT) and expression extracellular heat shock protein 90α (eHSP90α) that contributes acquired resisitance. Our provides a new sight into treatment EGFR-mutated NSCLC. Materials Methods: We performed western blotting detect levels EMT eHSP90α. Wound...
Metal and metal oxide nanoparticles (NPs) embedded in glass matrixes exhibit special optical, electrical, or magnetic properties. Despite various approaches of encapsulating NPs different kinds glasses to prepare functional composite materials, there still exist challenges fabricating efficiency performance for silica made by traditional methods, such as sol–gel melt quenching. Herein, the authors report a facile way fabricate NP‐doped digital light processing (DLP) 3D printing technology...
The pink pineapple mealybug, Dysmicoccus brevipes (Cockerell) (Hemiptera: Pseudococcidae), is a widespread plant-sucking insect of considerable concern because it transmits the mealybug wilt-associated virus. purpose this study was to use molecular methods clarify relationship among mealybugs from China, Philippines, Thailand and Hawaii, in an effort determine geographic origin introduction China. Pink samples were collected 10 counties 5 provinces Hawaii obtained. Parts mitochondrial genes...
Animals integrate sensory information from the environment and display various behaviors in response to external stimuli. In Caenorhabditis elegans hermaphrodites, 33 types of neurons are responsible for chemosensation, olfaction, mechanosensation. However, functional roles all have not been systematically studied due lack facile genetic accessibility. A bipartite cGAL-UAS system has previously developed study tissue- or cell-specific functions C. . Here, we report a toolkit new cGAL drivers...
Cell division requires constriction of an actomyosin ring to segregate the genetic material equally into two daughter cells. The spatial and temporal regulation contractile at plane primarily depends on intracellular signals mediated by centralspindlin complex astral microtubules. Although much investigative work has elucidated factors mechanisms controlling this process, extracellular cytokinesis remains unclear. Thus far, matrix protein Hemicentin (HIM-4) been proposed be required for...
Abstract Neuropeptides are evolutionarily conserved modulators of many aspects animal behavior and physiology, expand the repertoire processes that can be controlled by a limited number neurons. Deciphering neuropeptidergic codes govern distinct requires systematic functional analyses neuropeptides their cognate receptors. Even in well-studied model organisms like Caenorhabditis elegans, however, such efforts have been precluded lack mutant reagents. Here, we generated screened 21 C. elegans...
Chemical communication is vital in organismal health, reproduction, and overall well-being. Understanding the molecular pathways, neural processes, computations governing these signals remains an active area of research. The nematode Caenorhabditis elegans provides a powerful model for studying processes as it produces volatile sex pheromone. This pheromone synthesized by virgin females or sperm-depleted hermaphrodites serves attractant males. protocol describes detailed method isolating...
Chemotaxis to a potential mate who is moving and emitting volatile sex pheromone poses navigation challenge that requires rapid, precise responses maximize reproductive success. We demonstrate Caenorhabditis elegans males address this by utilizing two detectors located in head tail sensory neurons. Despite sharing receptor SRD-1, AWA neurons promote forward movement acceleration, while PHD induce reversals deceleration. In increasing gradients dominates; whereas weakening inactivate AWAs,...