A5033624132- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Retinal Diseases and Treatments
- Reproductive Biology and Fertility
- Spaceflight effects on biology
- Intraocular Surgery and Lenses
- Parasite Biology and Host Interactions
- Retinal and Macular Surgery
- Biomedical Text Mining and Ontologies
- CRISPR and Genetic Engineering
- Bioinformatics and Genomic Networks
- Retinal and Optic Conditions
- Nematode management and characterization studies
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Parasites and Host Interactions
- Traumatic Ocular and Foreign Body Injuries
- Entomopathogenic Microorganisms in Pest Control
- Ocular Diseases and Behçet’s Syndrome
- Genomics and Phylogenetic Studies
- Insect Resistance and Genetics
- Insect symbiosis and bacterial influences
- Helminth infection and control
- Microbial Metabolic Engineering and Bioproduction
California Institute of Technology
2016-2025
Nashville Oncology Associates
2003-2024
Vanderbilt University Medical Center
2011-2023
University of Alabama in Huntsville
2023
University of Naples Federico II
2023
Université Paris Cité
2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2023
Centre National de la Recherche Scientifique
2023
Délégation Paris 7
2023
University of Chicago
2023
The Gene Ontology (GO) project (http://www. geneontology.org/) provides structured, controlled vocabularies and classifications that cover several domains of molecular cellular biology are freely available for community use in the annotation genes, gene products sequences. Many model organism databases genome groups GO contribute their sets to resource. database integrates contributed annotations full access this information formats. Members Consortium continually work collectively,...
We have developed Textpresso, a new text-mining system for scientific literature whose capabilities go far beyond those of simple keyword search engine. Textpresso's two major elements are collection the full text articles split into individual sentences, and implementation categories terms which database sentences can be searched. The classes biological concepts (e.g., gene, allele, cell or group, phenotype, etc.) that relate objects association, regulation, describe one process, etc.)....
In addition to preventing crosstalk among related signaling pathways, scaffold proteins might facilitate signal transduction by preforming multimolecular complexes that can be rapidly activated incoming signal. many cases, such as mitogen-activated protein kinase (MAPK) cascades, are necessary for full activation of a pathway. To date, however, no detailed biochemical model action has been suggested. Here we describe quantitative computer MAPK cascade with generic protein. Analysis this...
Abstract Detailed descriptions are given of the amphimictic nematode strains PS1158, PS2052 and PS2160, which unusual in that they only differ predominant body handedness. Although these morphologically identical all other respects, published reproductive data new DNA sequence D2/D3 region large subunit rRNA gene show do represent two separate species. On basis comparison with type material, left-handed PS1158 PS2160 identified as Acrobeloides bodenheimeri, right-handed strain A....
WormBase (http://www.wormbase.org) is a central data repository for nematode biology. Initially created as service to the Caenorhabditis elegans research field, has evolved into powerful tool in its own right. In past 2 years, we expanded include complete genomic sequence, gene predictions and orthology assignments from range of related nematodes. This comparative enrich C. with improved better understanding function. turn, they bring wealth experimental knowledge other systems medical...
WormBase (www.wormbase.org) is a central repository for research data on the biology, genetics and genomics of Caenorhabditis elegans other nematodes. The project has evolved from its original remit to collect integrate all single species, now extends numerous nematodes, ranging evolutionary comparators C. parasitic species that threaten plant, animal human health. Research activity using as model system vibrant ever, we have created new tools community curation in response ever-increasing...
Abstract WormBase (https://wormbase.org/) is a mature Model Organism Information Resource supporting researchers using the nematode Caenorhabditis elegans as model system for studies across broad range of basic biological processes. Toward this mission, efforts are arranged in three primary facets: curation, user interface and architecture. In update, we describe progress each these areas. particular, discuss status literature curation recently added data, detail new features web options...
Background Cumulative oxidative damage is implicated in the pathogenesis of age-related macular degeneration (AMD). Nuclear factor erythroid 2-related 2 (NRF2) a transcription that plays key roles retinal antioxidant and detoxification responses. The purposes this study were to determine whether NRF2-deficient mice would develop AMD-like pathology with aging explore underlying mechanisms. Methods Findings Eyes both wild type Nrf2−/− examined vivo by fundus photography electroretinography...
The genome of the common roundworm Ascaris suum, a major parasite in many parts world, has now been sequenced. Analyses reveal genes that encode peptidases linked to penetration and degradation host tissues, as well molecules likely modulate or evade immune responses. availability this sequence should contribute towards development new therapeutic interventions against ascariasis other nematode infections. Parasitic diseases have devastating, long-term impact on human health, welfare food...