A5063280401- Mycotoxins in Agriculture and Food
- Fibroblast Growth Factor Research
- Biomedical Text Mining and Ontologies
- Invertebrate Immune Response Mechanisms
- Erythrocyte Function and Pathophysiology
- Bioinformatics and Genomic Networks
- Cellular transport and secretion
- Wheat and Barley Genetics and Pathology
- Insect Resistance and Genetics
- Mosquito-borne diseases and control
- Genetics, Aging, and Longevity in Model Organisms
- Malaria Research and Control
- Genomics and Phylogenetic Studies
- Microbial Metabolic Engineering and Bioproduction
- Lipid Membrane Structure and Behavior
- Genetics, Bioinformatics, and Biomedical Research
- Radioactive element chemistry and processing
- Plant and fungal interactions
- CRISPR and Genetic Engineering
- Pancreatic function and diabetes
- Neurobiology and Insect Physiology Research
- Insect Utilization and Effects
- Phagocytosis and Immune Regulation
- Pesticide Residue Analysis and Safety
- Endoplasmic Reticulum Stress and Disease
California Institute of Technology
2015-2025
Heidelberg University
2015-2024
University of Helsinki
2023
University Hospital Heidelberg
2023
Heidelberg University
2017-2023
Helsinki Institute of Physics
2023
Czech Academy of Sciences, J. Heyrovský Institute of Physical Chemistry
2023
Freie Universität Berlin
2023
University of Oxford
2018
Deutsches Diabetes-Zentrum e.V.
2016
We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity and detected marked diversification relative to Drosophila melanogaster. Immune-related involved recognition, signal modulation, effector systems show a deficit of orthologs excessive expansions, possibly reflecting selection pressures different pathogens encountered these insects' very life-styles. In contrast, the multifunctional Toll transduction pathway is substantially conserved,...
We have developed Textpresso, a new text-mining system for scientific literature whose capabilities go far beyond those of simple keyword search engine. Textpresso's two major elements are collection the full text articles split into individual sentences, and implementation categories terms which database sentences can be searched. The classes biological concepts (e.g., gene, allele, cell or group, phenotype, etc.) that relate objects association, regulation, describe one process, etc.)....
The disulfide reducing enzymes glutathione reductase and thioredoxin are highly conserved among bacteria, fungi, worms, mammals. These proteins maintain intracellular redox homeostasis to protect the organism from oxidative damage. Here we demonstrate absence of in Drosophila melanogaster, identify a new type reductase, provide evidence that system supports GSSG reduction. Our data suggest antioxidant defense Drosophila, probably related insects, differs fundamentally other organisms.
WormBase (http://www.wormbase.org) is a central data repository for nematode biology. Initially created as service to the Caenorhabditis elegans research field, has evolved into powerful tool in its own right. In past 2 years, we expanded include complete genomic sequence, gene predictions and orthology assignments from range of related nematodes. This comparative enrich C. with improved better understanding function. turn, they bring wealth experimental knowledge other systems medical...
WormBase (www.wormbase.org) is a central repository for research data on the biology, genetics and genomics of Caenorhabditis elegans other nematodes. The project has evolved from its original remit to collect integrate all single species, now extends numerous nematodes, ranging evolutionary comparators C. parasitic species that threaten plant, animal human health. Research activity using as model system vibrant ever, we have created new tools community curation in response ever-increasing...
Abstract WormBase (https://wormbase.org/) is a mature Model Organism Information Resource supporting researchers using the nematode Caenorhabditis elegans as model system for studies across broad range of basic biological processes. Toward this mission, efforts are arranged in three primary facets: curation, user interface and architecture. In update, we describe progress each these areas. particular, discuss status literature curation recently added data, detail new features web options...
Abstract WormBase (www.wormbase.org) is the central repository for genetics and genomics of nematode Caenorhabditis elegans. We provide research community with data tools to facilitate use C. elegans related nematodes as model organisms studying human health, development, many aspects fundamental biology. Throughout our 22-year history, we have continued evolve reflect progress innovation in science technologies involved study strive incorporate new types richer sets, integrated displays...
The progressive deposition of misfolded hyperphosphorylated tau is a pathological hallmark tauopathies, including Alzheimer's disease. However, the underlying molecular mechanisms governing intercellular spreading species remain elusive. Here, we show that full-length soluble unconventionally secreted by direct translocation across plasma membrane. Increased secretion favored hyperphosphorylation, which provokes microtubule detachment and increases availability free protein inside cells....
WormBase (http://www.wormbase.org) is an important knowledge resource for biomedical researchers worldwide. To accommodate the ever increasing amount and complexity of research data, continues to advance its practices on data acquisition, curation retrieval most effectively deliver comprehensive about Caenorhabditis elegans, genomic information other nematodes parasitic flatworms. Recent notable enhancements include user-directed submission such as micropublication; presentation, including...
The Alliance of Genome Resources (the Alliance) is a combined effort 7 knowledgebase projects: Saccharomyces Database, WormBase, FlyBase, Mouse the Zebrafish Information Network, Rat and Gene Ontology Resource. seeks to provide several benefits: better service various communities served by these projects; harmonized view data for all biomedical researchers, bioinformaticians, clinicians, students; more sustainable infrastructure. has cross-organism useful comparative views gene function,...
Abstract WormBase has been the major repository and knowledgebase of information about genome genetics Caenorhabditis elegans other nematodes experimental interest for over 2 decades. We have 3 goals: to keep current with fast-paced C. research, provide better integration resources, be sustainable. Here, we discuss state as well progress plans moving core infrastructure Alliance Genome Resources (the Alliance). As an member, will continue interact community, develop new features needed,...
Abstract The Alliance of Genome Resources (Alliance) is an extensible coalition knowledgebases focused on the genetics and genomics intensively studied model organisms. organized as individual knowledge centers with strong connections to their research communities a centralized software infrastructure, discussed here. Model organisms currently represented in are budding yeast, Caenorhabditis elegans, Drosophila, zebrafish, frog, laboratory mouse, rat, Gene Ontology Consortium. project rapid...
Immune responses of the malaria vector mosquito Anopheles gambiae were monitored systematically by induced expression five RNA markers after infection challenge. One newly isolated marker encodes a homologue moth Gram-negative bacteria-binding protein (GNBP), and another corresponds to serine protease-like molecule. Additional previously described that respond immune challenge encode antimicrobial peptide defensin, putative galactose lectin, protease. Specificity was indicated differing...
Cell lines from the malaria vectorAnopheles gambiae have been established as a tool for study of mosquito innate immune system in vitro. Here, we describe first continuous insect cell line that produces prophenoloxidase (PPO). This (4a-3B) expresses constitutively six PPO genes, three which are novel (PPO4, PPO5, andPPO6). The genes show distinct temporal expression profiles intact mosquito, spanning stages embryo to adult an overlapping manner. Transient induction larva-specific blood-fed...
With support from the Institutes and Centers forming NIH Blueprint for Neuroscience Research, we have designed implemented a new initiative integrating access to use of Web-based neuroscience resources: Information Framework. The Framework arises expressed need community neuroinformatic tools resources aid scientific inquiry, builds upon prior development neuroinformatics by Human Brain Project others, directly derives Society Neuroscience's Database Gateway. Partnered with Society, its...
Two modes of refractoriness to Plasmodium, ookinete lysis and melanization, are known in the malaria vector, Anopheles gambiae. Melanization, a potent insect immune response, is manifested genetically selected refractory strain susceptible mosquitoes that depleted specific C-type lectins (CTLs). Here we use systematic vivo RNA interference-mediated reverse genetic screen other recent results define melanization-regulating module or network. It encompasses at least 14 genes, including those...
Since its release in 2000, WormBase (http://www.wormbase.org) has grown from a small resource focusing on single species and serving dedicated research community, to one now spanning 15 essential the broader biomedical agricultural fields. To enhance rate of curation, we have automated identification key data scientific literature use similar methodology for extraction. ease access data, are collaborating with journals link entities publications their report pages at WormBase. facilitate...
WormBase (http://www.wormbase.org/) is a highly curated resource dedicated to supporting research using the model organism Caenorhabditis elegans. With an electronic history predating World Wide Web, contains information ranging from sequence and phenotype of individual alleles genome-wide studies generated next-generation sequencing technologies. In recent years, we have expanded contents include data on additional nematodes agricultural medical significance, bringing knowledge C. elegans...
This paper presents important results of the European HVDC Study Group founded on an initiative by German Commission for Electrical, Electronic and Information Technologies in September 2010. The main task has been defining "Technical Guidelines first Grids": 1) to gain a common understanding basic operating design principles grid systems, 2) prepare ground more detailed standardization work. systems are moving from stage point-to-point (PTP) connectors transmission interconnecting than two...
Fibroblast growth factor 2 (FGF2) is a critical mitogen with central role in specific steps of tumor-induced angiogenesis. It known to be secreted by unconventional means bypassing the endoplasmic reticulum/Golgi-dependent secretory pathway. However, mechanism FGF2 membrane translocation into extracellular space has remained elusive. Here, we show that phosphatidylinositol 4,5-bisphosphate-dependent recruitment causes oligomerize, which turn triggers formation lipidic pore putative toroidal...
The biomedical literature continues to grow at a rapid pace, making the challenge of knowledge retrieval and extraction ever greater. Tools that provide means search mine full text thus represent an important way by which efficiency these processes can be improved.
A novel mosquito antimicrobial peptide, gambicin, and the corresponding gene were isolated in parallel through differential display-PCR, an expressed sequence tag (EST) project, characterization of activity a cell line by reverse-phase chromatography. The 616-bp gambicin ORF encodes 81-residue protein that is processed secreted as 61-aa mature peptide containing eight cysteines engaged four disulfide bridges. Gambicin lacks homology with other known proteins. Like Anopheles gambiae genes,...