A5019146763- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Neural Networks and Applications
- Biomedical Text Mining and Ontologies
- Plant and Biological Electrophysiology Studies
- Neuroscience and Neuropharmacology Research
- Cephalopods and Marine Biology
- Semantic Web and Ontologies
- Genetics, Bioinformatics, and Biomedical Research
- Functional Brain Connectivity Studies
- Cell Image Analysis Techniques
- Advanced Memory and Neural Computing
- Olfactory and Sensory Function Studies
- Bioinformatics and Genomic Networks
- stochastic dynamics and bifurcation
- Civil and Structural Engineering Research
- Recommender Systems and Techniques
- Peer-to-Peer Network Technologies
- Data Quality and Management
- Speech and dialogue systems
- Evolutionary Algorithms and Applications
- Neuroscience, Education and Cognitive Function
Cornell University
2003-2022
New York University
1971-2001
University of Genoa
2000
George Mason University
2000
Toyohashi University of Technology
2000
Albert Einstein College of Medicine
1983
City University of New York
1971
With support from the Institutes and Centers forming NIH Blueprint for Neuroscience Research, we have designed implemented a new initiative integrating access to use of Web-based neuroscience resources: Information Framework. The Framework arises expressed need community neuroinformatic tools resources aid scientific inquiry, builds upon prior development neuroinformatics by Human Brain Project others, directly derives Society Neuroscience's Database Gateway. Partnered with Society, its...
Principles of functional organization the bilaterally symmetric buccal ganglia Aplysia were studied in 20 identified cells used as a reference population. Four (two each ganglion) are multiaction interneurons, which innervates six ipsilateral follower cells, mediating cholinergic excitation to one cell and inhibition five others. Bilateral coordination is effected by common inputs all four interneurons. Ipsilateral pairs interneurons electrotonically coupled produce identical synaptic...
1. The 26 identified neurons of Aplysia buccal ganglia include 4 interneurons and their follower cells. Each interneuron makes cholinergic synaptic connections on eight ipsilateral neurons. interneuronal action potential also produces a zero-latency, Mg-intensitive electrotonic coupling in one input from the interneurons. Electrotonic are bidirectional nonrectifying. 2. Ipsilateral pairs receive extensive common several unidentified neurons: each receives some not received by other. These...
Two identified interneurons in each buccal ganglion of Aplysia can mediate conjoined excitation and inhibition to a single follower cell. A presynaptic action potential one these produces diphasic, depolarizing-hyperpolarizing synaptic apparently as result transmitter acting on two types postsynaptic receptors the These produce potentials with differing reversal potentials, ionic conductances, time courses, rates decrement repetition, pharmacological properties, functional consequences. The...
1. Neurons of Aplysia buccal ganglia contain three types acetylcholine (ACh) receptors, each which has been characterized by its sensitivity to inhibitors and kinetics desensitization the properties conductance change it controls, including reversal potential, major ion, functional consequence. The receptors are classified as depolarizing, slowly decrementing hyperpolarizing, rapidly hyperpolarizing. Identified neurons innervated identified cholinergic multiaction interneurons; form...
1. In neurones BL and BR 3, 6, 8, 9, 10 11 of Aplysia buccal ganglia, cholinergic inhibitory post‐synaptic potentials are produced by activity in either two presynaptic cells. order to analyse the synaptic conductance change, were voltage‐clamped currents (i.p.s.c.) recorded. 2. The change rises an average peak value 0.65 micromho decays exponentially with single time constant tau 19 msec. 3. We have attempted identify rate‐limiting step responsible for i.p.s.c. decay from among following...
Objective: Generalizing the data models underlying two prototype neurophysiology databases, authors describe and propose Common Data Model (CDM) as a framework for federating broad spectrum of disparate neuroscience information resources. Design: Each component CDM derives from one five superclasses—data, site, method, model, reference—or relations defined between them. A hierarchic attribute-value scheme metadata enables interoperability with variable tree depth to serve specific intra- or...
1. Inhibitory post‐synaptic currents (i.p.s.c.s) were recorded under voltage clamp using two electrodes placed in neuronal somas of the buccal ganglia Aplysia, order to study effects membrane potential (Vm) on decay time constant (tau). 2. From ‐175 ‐40 mV, tau did not vary with Vm. At Vm more depolarized than decreased. Also at Vm, cell input resistance (Rin) decreased and many cells showed non‐exponential i.p.s.c. decay, including undershoot. These results suggest that apparently faster is...
1. In cholinergic neurones BL4, BL5, BR4, and BR5 of Aplysia buccal ganglia, each action potential is followed, in the same cell, by a curare- high-Mg-sensitive hyperpolarizing after-potential which enhanced Ca. 2. voltage-clamped neurons, substracting currents recorded curare from sea water reveals that this due to curare-sensitive rise peak, then decay exponentially with an apparently voltage-independent time constant 43 msec. Currents are produced voltage-independent, Ca-enhanced,...
The Neuroscience Information Framework (NIF), developed for the NIH Blueprint Research and available at http://nif.nih.gov http://neurogateway.org , is built upon a set of coordinated terminology components enabling data web-resource description selection. Core NIF terminologies use straightforward syntax designed ease navigation by familiar web interfaces, readily exportable to aid development relational-model databases neuroscience sharing. Datasets, analysis tools, resources, other...
1. In Aplysia buccal ganglia, in which dual presynaptic neurons innervate multiple postsynaptic cells, strengths of the same identified synapses differ from animal to animal, consistent with developmental or plastic modulation. Synaptic are specified by neuron, so that synaptic current amplitudes similar for inputs different cells converging on a cell but branches neuron diverging onto targets. 2. The coefficient variation method quantal analysis reveals differences strength, although...
1. Inhibitory post‐synaptic currents (i.p.s.c.s) were recorded under voltage clamp from neurones of Aplysia buccal ganglia. 2. The synaptic charge, Q, transferred by each i.p.s.c. was calculated as the time integral current, approximated numerical integration. For typical i.p.s.c.s at or near resting potential, Q = ‐100 to ‐500 pC. majority charge is during interval between peak and a one constant later. 3. In order characterize an alternative measurement efficacy, slope vs. membrane...
We have implemented a pair of database projects, one serving cortical electrophysiology and the other invertebrate neurones recordings. The design for each combines aspects two proven schemes information interchange. journal article metaphor determined type, scope, organization quantity data to comprise submission. Sequence databases encouraged intuitive tools viewing, capture, direct submission by authors. Neurophysiology required transcending these models with new datatypes. Time–series,...
In order to examine the relative contributions of changes in amplitude and time course synaptic plasticity, variations peak constant decay have been analyzed from inhibitory postsynaptic currents (PSC) recorded voltage-clamped Aplysia buccal ganglia neurons. these cells, with single can be low noise under well-controlled space clamp. Over a population 36 neurons, duration was more narrowly distributed than amplitude, but each varied. The coefficient variation (CV) 0.21 for (tau) 0.87...
Several identified neurons of the Aplysia buccal ganglia respond to choline. Iontophoretic applications either choline or acetylcholine (ACh) voltage-clamped inhibitory follower produce similar currents. Peak amplitudes responses were 10-100% ACh on same cell. Choline currents curare blockable and reversed at -69 +/- 2 mV, within 1 mV postsynaptic current (IPSC) reversal. Application mM bath produces more prolonged effects than an initial conductance change. depressed IPSC amplitude by 42 5%...
1. Presynaptic neurons B4 and B5 of Aplysia buccal ganglia produce similar inhibitory postsynaptic currents (PSCs) in several follower cells. Two previous papers have characterized the variability synaptic current amplitude decay time both for individual PSCs also mean values characterizing synapses compared PSC course at different sharing a common presynaptic or neuron. 2. To distinguish similarity introduced by pre- neuron from because factors to particular ganglion animal, paired were...