A5100405050- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Acute Ischemic Stroke Management
- Intraocular Surgery and Lenses
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Retinal Diseases and Treatments
- Sex work and related issues
- Autophagy in Disease and Therapy
- Tuberculosis Research and Epidemiology
- Traumatic Ocular and Foreign Body Injuries
- Fungal Infections and Studies
- Hepatitis B Virus Studies
- Neurological disorders and treatments
- Liver Disease Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Adipokines, Inflammation, and Metabolic Diseases
- Immune cells in cancer
- Amyotrophic Lateral Sclerosis Research
- Retinal Imaging and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Hepatitis C virus research
- Cholinesterase and Neurodegenerative Diseases
- Venous Thromboembolism Diagnosis and Management
Tianjin Medical University
2015-2025
Weifang Medical University
2025
Westmead Institute
2021-2025
Westmead Institute for Medical Research
2021-2025
Westmead Hospital
2021-2025
The University of Sydney
2021-2025
Central South University
2023-2025
West China Medical Center of Sichuan University
2021-2024
Lanzhou Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Colon cancer is a common type of worldwide and accounts for significant number cancer‑related deaths. Although surgical techniques treatment strategies colon have advanced over the past two decades, prognosis has not improved considerably. Resveratrol, natural stilbene compound, possesses antioxidant, cardioprotective anticancer properties. However, role resveratrol in been fully elucidated. The present study demonstrated that inhibited cell proliferation colony growth DLD1 HCT15 cells, but...
Chronic low-grade inflammation is regarded to an important signature of atherosclerosis (AS). Macrophage (Mψ) and related polarization have been demonstrated play a crucial role in the occurrence development AS inflammation. Butyrate, bioactive molecule produced by intestinal flora, has increasingly exhibit vital for regulating chronic metabolic diseases. However, effectiveness multiple anti-inflammation mechanisms butyrate on still need be further understood. ApoE −/− mice fed with high-fat...
Background: Neutrophils rapidly accumulate in large numbers at sites of tissue damage, exhibiting not only their well-known bactericidal capabilities but also playing crucial roles angiogenesis and repair. While exosomes derived from human umbilical cord mesenchymal stem cells (HucMSC-Exo) have emerged as a promising therapeutic tool, exact mechanisms action remain partly elusive. We hypothesize that HucMSC-Exo treatment may modulate neutrophil phenotypes, thereby significantly influencing...
The paramyxovirus parainfluenza virus 5 (PIV5) enters cells by fusion of the viral envelope with plasma membrane through concerted action (F) protein and receptor binding hemagglutinin-neuraminidase. F folds initially to form a trimeric metastable prefusion that is triggered undergo large-scale irreversible conformational changes postfusion conformation. It thought refolding couples energy released fusion. synthesized as precursor (F0) must be cleaved host protease biologically active...
Abstract The aim of this study is to investigate the impact exercise on intermediate disease markers in populations with overweight and obesity, providing evidence-based recommendations for clinicians utilize these developing prescriptions group. was conducted by retrieving data from PubMed, Embase, Cochrane Library, Web Science, CNKI only including Randomized Controlled Trials (RCTs) examine effect different interventions obese people. quality included studies evaluated using Bias Risk...
Background Stroke is the second most common cause of mortality in China. Although subtypes ischemic stroke share similar risk factors, they have different etiologies. Our study aimed to evaluate factor profiles between subtypes, lacunar infarcts (LI) and large-artery atherosclerosis (LAA), clarify characteristics current acute Methods In this cross-sectional study, we analyzed clinical 1982 patients with who were admitted neurology department at Peking University First Hospital 2007 2014....
Lung adenocarcinoma (AD) is a common variant of non-small cell lung cancer (NSCLC). Programmed death protein 1/programmed ligand 1 (PD1/PD-L1) are promising immunotherapy targets and its expression may be an important biomarker predicting clinical response. In this study, we evaluated PD-L1 in conjunction with clinicopathological characteristics outcomes resected adenocarcinoma.This study included 133 cases adenocarcinoma. rate was 16.5% at the mRNA level 13.5% level, kappa coefficient two...
Sustained suppression of VEGF is needed in many patients with neovascular age-related macular degeneration (NVAMD), and gene transfer a VEGF-neutralizing protein promising approach to achieve it. Initial clinical trials testing this have shown encouraging signals, but evidence robust transgene expression consistent antiangiogenic antipermeability activity has been lacking. In study, we demonstrate an anti-human antibody fragment (antiVEGFfab) after subretinal injection AAV8-antiVEGFfab....
Disturbances in immunoregulation may lead to both cancer and autoimmune diseases. Many therapeutic drugs for diseases also display anti-tumor efficacy. The Janus kinase/signal transducer activator of transcription signaling pathways are involved the secretion more than 50 distinct cytokines, which have critical roles inducing tumorigenesis. Thus, kinases become classical immunotherapeutic targets immune disease. More 70 kinase inhibitors been approved as immunomodulatory clinical use, 12...
Hepatitis B virus (HBV) DNA integration into the host cell genome is reportedly a major cause of liver cancer, and source hepatitis surface antigen (HBsAg). High HBsAg levels can alter immune responses which therefore contributes to progression HBV-related disease. However, what extent leads persistent circulating unclear. Here, we aimed determine if HBV associated with persistence in people exposed HBV. We established digital droplet quantitative inverse PCR (dd-qinvPCR) method quantify...
Hepatocellular carcinoma (HCC) is an aggressive form of liver cancer. Gamma Knife a minimally invasive treatment option for cancer, but it has limitations such as the potential cancer recurrence and metastasis. In contrast, Photodynamic Therapy (PDT) offers targeted approach, repeatability, immune regulation enhancement, facilitation systemic treatment. However, traditional PDT faces in treating deep-seated tumors, HCC. Copper cysteamine (Cu-Cy), novel photosensitizer activated directly by...
BACKGROUND Several studies have suggested a close link between depression, overweight, and new-onset diabetes, particularly among middle-aged older populations; however, the causal associations remain poorly understood. AIM To investigate role of overweight in mediating association depression diabetes populations. METHODS Data 9426 individuals aged ≥ 50 years from 1998-2016 Health Retirement Study database were analyzed. Weighted logistic regression was employed to obtain odds ratios (ORs)...
The objective of this study is to measuring the morphology and position bilateral temporomandibular joints in patients with unilateral molar scissor bite simulating deformation mandible during occlusion, order provide thesis for diagnosis joint disease bite. This was a retrospective study. A total 10 (the group) were selected as experimental group, 20 adult classⅠ angle classification similar ages control group. All underwent cone beam computed tomography scans, by width fossa, height...
Clinical trials in patients with macular edema due to diabetic retinopathy or retinal vein occlusion (RVO) have shown that suppression of VEGF not only improves edema, but also reopens closed vessels, prevents progression vessel closure, and retinopathy. In this study, we show the molecular basis for those clinical observations. Increased levels mice cause plugging vessels leukocytes, hypoxia. Suppression reduces leukocyte plugging, causing reperfusion vessels. Activation VEGFR1 contributes...
To explore the association between three-dimensional (3D) cardiac magnetic resonance (CMR) feature tracking (FT) right ventricular peak global longitudinal strain (RVpGLS) and major adverse cardiovascular events (MACEs) in patients with stage C or D heart failure (HF) non-ischaemic dilated cardiomyopathy (NIDCM) but without atrial fibrillation (AF).Patients were enrolled this prospective cohort study. Comprehensive clinical biochemical analysis CMR imaging performed. All followed up for...
Idiopathic pulmonary fibrosis is a progressive fatal disease characterized by interstitial remodeling, with high lethality and lack of effective medical therapies. Tetrandrine has been proposed to present anti-fibrotic effects, but the efficacy mechanisms have not systematically evaluated. We sought study potential therapeutic effects tetrandrine against lung fibrosis. The were evaluated in bleomycin-induced mouse models TGF-β1-stimulated murine fibroblasts. performed Chromatin...
Monocytes are the predominant innate immune cells at early stage of Mycobacterium tuberculosis (M. tb) infection as host defense against intracellular pathogens. Understanding profile different monocyte subpopulations and dynamics monocyte-related biomarkers may be useful for diagnosis prognosis tuberculosis.We enrolled 129 individuals comprising patients with pulmonary (PTB) (n = 39), tuberculous pleurisy (TBP) 28), malignant pleural effusion (MPE) 21), latent (LTBI) 20), healthy controls...