A5101857658- Hair Growth and Disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- RNA regulation and disease
- Autoimmune Bullous Skin Diseases
- Dermatology and Skin Diseases
- Acute Myocardial Infarction Research
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Venous Thromboembolism Diagnosis and Management
- Celiac Disease Research and Management
- Cancer and Skin Lesions
- Viral-associated cancers and disorders
- Microscopic Colitis
- Wound Healing and Treatments
- Corneal surgery and disorders
- Nail Diseases and Treatments
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Corneal Surgery and Treatments
- Blood transfusion and management
- Drug-Induced Adverse Reactions
- Autoimmune and Inflammatory Disorders
- Lichen and fungal ecology
- Acute Ischemic Stroke Management
Westmead Hospital
2024-2025
The University of Melbourne
2014-2024
St Vincent's Hospital
2013-2024
Skin Health Institute
2022-2024
Eastern Health
2023-2024
Box Hill Hospital
2023
University of Cambridge
2023
Auckland City Hospital
2021
Peter Doherty Institute
2015-2016
Epworth Hospital
2015
Abstract Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that CD4 + in mouse skin are equilibrium the circulation steady state. These dispersed throughout inter-follicular regions of dermis and form clusters antigen presenting around hair follicles. After infection or administration a contact sensitizing agent, there sustained increase T-cell content, confined...
Disruption of T cell memory during severe immune suppression results in reactivation chronic viral infections, such as Epstein Barr virus (EBV) and Cytomegalovirus (CMV). How different subsets cells contribute to the protective immunity against these viruses remains poorly defined. In this study we examined compartmentalization virus-specific, tissue resident CD8+ human lymphoid organs. This revealed two distinct populations cells, that were CD69+CD103+ CD69+CD103-, retained within spleen...
Current measures of alopecia areata (AA) severity, such as the Severity Alopecia Tool score, do not adequately capture overall disease impact.
Hepatitis B virus (HBV) DNA integration into the host cell genome is reportedly a major cause of liver cancer, and source hepatitis surface antigen (HBsAg). High HBsAg levels can alter immune responses which therefore contributes to progression HBV-related disease. However, what extent leads persistent circulating unclear. Here, we aimed determine if HBV associated with persistence in people exposed HBV. We established digital droplet quantitative inverse PCR (dd-qinvPCR) method quantify...
Abstract Background/Objectives Mucosal‐associated invariant T ( MAIT ) cells are a novel subset of innate‐like T‐cells that enriched in mucosal tissues. Their presence human skin has only recently been recognised. We describe the expression skin‐tropic molecules on at steady state and investigate their contribution to various dermatoses with known T‐cell involvement. Methods To examine by state, we performed flow cytometric analysis blood samples from healthy donors. any potential wider...
Human skin contains various populations of memory T cells in permanent residence and transit. Arguably, the best characterized subsets are CD8+ permanently resident (TRM) expressing integrin subunit, CD103. In order to investigate remaining cells, we isolated skin-tropic (CLA+) helper regulatory CD103- from blood for RNA microarray analysis compare transcriptional profiles these groups. We found that despite their common tropism, were transcriptionally distinct blood-derived CLA+ cells. A...
Solid organ transplant recipients (SOTR) are at high risk of keratinocyte carcinoma (KC). Long-term evidence for acitretin as chemoprophylaxis in this population is lacking.To determine the benefit long-term KC chemoprevention SOTR.A retrospective cohort study SOTR treated with an Australian dermatology clinic was performed. General estimating equations were used to evaluate change rates histologically confirmed 6-12 months prior and following a minimum 6 treatment. A control group patients...
Mycophenolate use in dermatology is growing due to its reputation as a steroid-sparing agent with favourable side-effect profile. However, there are limited data on the efficacy and tolerability of mycophenolate for many dermatological indications. We conducted retrospective clinical audit 33 patients who had received at our institution between April 2010 January 2012. The top indication was pyoderma gangrenosum (14 patients) followed by atopic dermatitis (seven patients). Overall 70 per...
Abstract Background High/intermediate‐risk pulmonary embolism (PE) confers increased risk of cardiovascular morbidity and mortality. International guidelines recommend the formation a PE response team (PERT) for management because complexity stratification emerging treatment options. However, there are currently no available Australian data regarding outcomes managed through PERT. Aims To analyse clinical outcome patients from an centre with high/intermediate‐risk requiring PERT‐guided...
Alopecia areata (AA) is a T-cell-mediated hair loss disorder but the exact cause unknown. In this report we describe patterns of onset, regrowth and relapse in AA propose potential underlying mechanisms. We believe that these aspects require integration into modern theories pathogenesis.
<h3>Aims and Objectives</h3> Trauma is a leading cause of death for those under 44. Patients with blood group O (bgO) have been reported to higher mortality. The existing hypothesis (that lower levels circulating von Willebrand factor/factor VIII in patients bgO increases mortality through bleeding tendency) has not tested. Our study uniquely investigates the association between all ABO Rh groups 30-day all-cause large adult trauma patient cohort. Understanding post-trauma physiological...
Corneal neovascularization (NV) is usually associated with inflammatory or infectious disorders of the ocular surface and often accompanied by stromal edema, lipid deposits, keratitis, scarring. All which frequently results in vision impairment blindness. Pathological angiogenesis also thought to predispose reflection corneal allografts facilitating exposure antigens donor cornea immune system. Many medical surgical treatments, including angiostatic steroid, nonsteroidal anti-inflammatory...