A5079579846- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders
- Autoimmune Bullous Skin Diseases
- Oral Health Pathology and Treatment
- Hidradenitis Suppurativa and Treatments
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Urticaria and Related Conditions
- Neonatal Respiratory Health Research
- Dyeing and Modifying Textile Fibers
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Eosinophilic Disorders and Syndromes
- Skin Protection and Aging
- Hair Growth and Disorders
- Inflammasome and immune disorders
- Myasthenia Gravis and Thymoma
- Skin Diseases and Diabetes
- Vascular anomalies and interventions
- Venous Thromboembolism Diagnosis and Management
- Inflammatory Bowel Disease
- Streptococcal Infections and Treatments
- Dermatological and COVID-19 studies
- Fungal Infections and Studies
St Vincent's Hospital
2016-2025
The University of Melbourne
2013-2023
Royal Liverpool University Hospital
2020
University of Liverpool
2020
Cell Biotech (South Korea)
2020
Synthetic Biologics (United States)
2018
Kookmin University
2018
St George's Hospital
1993-2006
Skin and Cancer Foundation
2005
Government of Western Australia
1996
Maternal corticosteroid treatments augment lung function in the human preterm infant. However, not all fetuses respond, response requires > or = 48 h of exposure, and multiple maternal doses expose mother to potential risks. To evaluate direct fetal therapy, we used ultrasound intramuscular intravascular injections corticosteroids saline sheep subsequently delivered lambs at 128 days gestational age assess postnatal function. Relative saline-injected controls, 0.5 2 mg/kg betamethasone given...
Skin moisturisation, elasticity, feel and appearance can all be improved through the topical application of protein hydrolysates. Recent studies suggest that supplementing intercellular lipids stratum corneum enhance functioning skin.In this study, a hydrolysed keratin peptide (molecular weight <1000 Da) was prepared from wool tested on skin in two different formulations: an aqueous solution internal (IWL) liposome suspension. In vivo long-term were performed to evaluate water barrier...
A female Infant presented at the age of five months with typical external manifestations Cushing's syndrome, due to percutaneous absorption betamethasone 17-valerate which had been applied areas seborrhœic dermatitis present for previous two months. Some equivocal results were obtained from investigations performed exclude a primary adrenal disorder, but situation was clarified by gradual disappearance Cushingold features after topical application stopped. No report has found syndrome...
SUMMARY A retrospective analysis was conducted on 93 adult patients with cutaneous leukocytoclastic vasculitis from St. Vincent's Hospital Melbourne to determine the classification, aetiology, severity and prognosis of this population patients. We developed a new classification system for purposes our study based modifications Chapel Hill Consensus Conference definitions vasculitic syndromes. The results indicate that an obvious cause not found in 44.1% Of secondary vasculitis, commonest...
In 3 cases of acrodermatitis enteropathica duodenal biopsy performed at the outset treatment showed a similar abnormality intestinal mucosa. Further biopsies taken during progressive improvement mucosa with subsequent complete restoration normal cellular and villous pattern. The initial was expressed human breast milk oral di-iodohydroxyquinoline. latter continued alone later replaced by zinc sulphate. Changes in epithelial cells inflammatory cell infiltration lamina propria still detectable...
SUMMARY A number of patients presented with an erythematous, purpuric rash occurring on the legs in association playing golf and also after prolonged walks or hikes. Many believed that it was allergic reaction to grasses insecticides had sometimes undergone extensive allergy testing. We collected reports 17 such cases from dermatologists state Victoria, Australia. Patients were interviewed by phone asked submit photographs if possible. Of these, eruption developed 15 18 holes three following...
A 66-year-old woman had a long-standing, scaly erythematous lesion on her left temple which histologically showed features of amelanotic lentigo maligna. It recurred numerous occasions over period 17 years, in spite multiple attempts at curative surgery. There were also recurrences within skin graft which, to our knowledge, has not been documented previously with In the prolonged course, and extensive intraepidermal melanocytic proliferation amounting melanoma situ, there no evidence dermal...
Intravenous immunoglobulins (IVIG) have been increasingly used for various inflammatory dermatoses with success. Small case series and reports suggest a role IVIG in the management of refractory pyoderma gangrenosum (PG).The objective was to study characteristics PG patients treated efficacy safety PG.An analysis performed all from 2012 2022 at an Australian tertiary hospital seeing high volume patients.We identified 12 patients, 9 females 3 males, median age 61 years (29-77) commencement....
A 53-year-old woman presented with a chronic history of recurrent, painful ulcers, predominantly involving her lower legs. Both clinical picture and histopathological findings were consistent diagnosis livedoid vasculopathy, although she did have unusual deep tender nodules the presence lesions over elbows. Multiple investigations undertaken, only abnormality being heterozygous mutation prothrombin G2021A gene. Although various coagulopathic states been associated finding an gene is quite...
SUMMARY A 33‐year‐old man presented with a 3‐month history of widespread pigmented purpuric eruption over his trunk and limbs. The clinical presentation histology were consistent diagnosis Schamberg's disease. rash initially cleared following short course oral prednisolone at 25 mg daily for 3 weeks, which was weaned the subsequent 4 weeks. Topical mometasone furoate ointment 0.1% also applied to active areas. recurred when reduced below 5 per day. To prevent further recurrence weaning...
ABSTRACT A 35‐year‐old Lebanese woman presented with a 3‐year history of persistent, localized livedo racemosa over her feet, distal legs and forearms that was associated the development lower limb sensorimotor neuropathy. Investigations revealed patient heterozygous for prothrombin gene mutation also found to have T‐cell receptor gamma chain rearrangement. Histological examination mid‐lower dermal medium vessel lymphocytic vasculitis prominent fibrinoid ring within its wall. These findings...
Mycophenolate use in dermatology is growing due to its reputation as a steroid-sparing agent with favourable side-effect profile. However, there are limited data on the efficacy and tolerability of mycophenolate for many dermatological indications. We conducted retrospective clinical audit 33 patients who had received at our institution between April 2010 January 2012. The top indication was pyoderma gangrenosum (14 patients) followed by atopic dermatitis (seven patients). Overall 70 per...
S ummary Skin changes associated with long term hydroxyurea therapy have only rarely been reported and are not widely known. This report concerns a patient in whom extensive debilitating skin developed secondary to therapy. In addition previously manifestations such as ichthyosis, dermatomyositis‐like eruption on the dorsal hands, facial erythema accelerated development of premalignant malignant lesions, an erosive glans penis. He also rapidly enlarging viral wart which clinically resembled...
Abstract Necrobiosis lipoidica ( NL ) is a rare chronic inflammatory granulomatous skin disorder that remains challenging to treat. Here we report three patients at different stages of disease successfully treated with pentoxifylline, haemorrheological and anti‐inflammatory agent. We demonstrate for the first time early stage may be completely reversible this treatment. Our findings are also consistent previous isolated reports showing effectiveness pentoxifylline in treating ulcerative .
We previously found that a single dose of betamethasone in combination with thyroxine given by intramuscular injection to fetal sheep 48 h before preterm delivery at 128 d gestation improved postnatal lung function. have now asked how the 0.5 mg/kg and 15 micrograms/kg T4 changes response after treatment 121 135 gestation. At hormone significantly Compliance increased 55%, arterial PO2 from 39 215 mm Hg, PCO2 decreased 109 79 maximal volumes 112%. The severity respiratory failure, although...
We describe three patients who presented with a striking erythematous non-blanching annular eruption and features of lymphocytic thrombophilic arteritis (LTA), prominent vasculitis involving deep dermal vessels. Lymphocytic inflammation was also evident in the superficial vessels one patient had small ulcers over ankle area resembling livedoid vasculopathy (LV). Multiple biopsies demonstrated persistent absence neutrophils infiltrate consistent process. In addition to highlighting morphology...
Nodular vasculitis (NV) refers to a chronic relapsing lobular panniculitis that is thought be hypersensitivity reaction antigenic triggers. While it commonly associated with tuberculosis, in many cases no underlying cause found and the condition difficult manage. Here, we report three patients refractory idiopathic NV effectively treated colchicine, leading significant improvement or complete resolution of their symptoms. Colchicine was successfully used as steroid-sparing agent, one patient...