A5049356083- Lymphatic System and Diseases
- Diagnosis and Treatment of Venous Diseases
- Systemic Sclerosis and Related Diseases
- Vascular Malformations and Hemangiomas
- Sympathectomy and Hyperhidrosis Treatments
- Body Contouring and Surgery
- Lymphatic Disorders and Treatments
- Cutaneous Melanoma Detection and Management
- Hidradenitis Suppurativa and Treatments
- Cutaneous lymphoproliferative disorders research
- Breast Cancer Treatment Studies
- Vascular Tumors and Angiosarcomas
- Skin and Cellular Biology Research
- Colorectal and Anal Carcinomas
- Thermoregulation and physiological responses
- Venous Thromboembolism Diagnosis and Management
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Genetic and rare skin diseases.
- Skin Diseases and Diabetes
- Nonmelanoma Skin Cancer Studies
- Chemotherapy-related skin toxicity
- Optical Coherence Tomography Applications
- Cancer and Skin Lesions
- Entomological Studies and Ecology
St George's, University of London
2015-2024
St George’s University Hospitals NHS Foundation Trust
2011-2024
Universität der Bundeswehr München
2021-2024
St George's Hospital
2009-2024
Genomics (United Kingdom)
2024
Kunming Institute of Botany
2023
Chinese Academy of Sciences
2023
University of London
2006-2022
St George's Hospital
2006-2021
Systems Technology (United States)
2021
Background: Lymphoedema/chronic oedema is an important cause of morbidity in the population, but little known its epidemiology and impact on patients or health services.
Abstract Generalized lymphatic dysplasia (GLD) is a rare form of primary lymphoedema characterized by uniform, widespread affecting all segments the body, with systemic involvement such as intestinal and/or pulmonary lymphangiectasia, pleural effusions, chylothoraces pericardial effusions. This may present prenatally non-immune hydrops. Here we report homozygous and compound heterozygous mutations in PIEZO1 , resulting an autosomal recessive GLD high incidence hydrops fetalis childhood onset...
Abstract Lipedema is a condition characterized by swelling and enlargement of the lower limbs due to abnormal deposition subcutaneous fat. an under‐recognized condition, often misdiagnosed as lymphedema or dismissed simple obesity. We present series pedigrees propose that lipedema genetic with either X‐linked dominant inheritance more likely, autosomal sex limitation. appears be almost exclusively affecting females, presumably estrogen‐requiring it usually manifests at puberty. entity...
Background. The psychological morbidity, functional impairment, and disturbance in psychosocial adjustment to illness was evaluated relation breast cancer-related arm swelling. Methods. Fifty women with swelling were matched 50 control subjects for age, duration since treatment, type of treatment received. All study participants free from active disease had been treated more than 1 year ago. Results. Patients showed greater morbidity at formal psychiatric interview, impaired as by the...
<b>Introduction:</b> Lymphoedema-distichiasis syndrome (LD) (OMIM 153400) is a rare, primary lymphoedema of pubertal onset, associated with distichiasis. Causative mutations have now been described in <i>FOXC2</i>, forkhead transcription factor gene. Numerous clinical associations reported this condition, including congenital heart disease, ptosis, varicose veins, cleft palate, and spinal extradural cysts. <b>Subjects:</b> We report findings 74 affected subjects from 18 families six isolated...
BACKGROUND Multilayered, low stretch bandages (MLB) combined with exercises, skin care, and manual lymphatic drainage therapy are recommended as an intensive phase of treatment for lymphedema patients. The relative efficacy each the components this comprehensive program have not been determined. This study aimed to compare effect multilayer bandaging initial followed by elastic hosiery versus alone. METHODS A randomized, controlled, parallel-group trial was undertaken in setting Lymphedema...
In order to examine whether anti-androgen therapy was effective in hidradenitis suppurativa (HS), ethinyloestradiol 50 micrograms/cyproterone acetate mg a reverse sequential regimen compared with micrograms/norgestrel 500 micrograms (Eugynon 50) 24 female patients. Both treatments produced substantial improvement disease activity. Seven patients cleared and have remained free of for 18 months, five improved, four unchanged, while two deteriorated. Cyproterone not clinically significantly...
A reduction in the density of capillaries (rarefaction) is known to occur many tissues patients with essential hypertension. This rarefaction may play a role increasing peripheral resistance. However, mechanism underlying this capillary not understood. The aim study was assess extent structural versus functional skin dorsum fingers microcirculation examined video microscopy before and after maximizing number perfused by venous congestion. group comprised 17 hypertension (mean supine blood...
We recently showed that rarefaction of skin capillaries in the dorsum fingers patients with essential hypertension is due to structural (anatomic) absence rather than functional nonperfusion. It not known whether this primary (ie, antedates onset hypertension) or secondary as a consequence sustained and prolonged elevation blood pressure [BP]). The aim present investigation was study capillary density group mild borderline assess BP. included 18 (mean supine BP, 136/83 mm Hg), 32...
This paper describes a randomized controlled crossover study examining the effects of manual lymphatic drainage (MLD) in 31 women with breast cancer-related lymphoedema. MLD is type massage used combination skin care, support/compression therapy and exercise management A modified version MLD, referred to as simple (SLD), commonly taught self-help measure. There has been limited research into efficacy SLD. The reported here explores SLD on range outcome measures. findings demonstrate that...
Background— Mutations in the FOXC2 gene cause lymphedema distichiasis, an inherited primary which a significant number of patients have varicose veins. Because distichiasis is believed to be caused by lymphatic valve failure (reflux), and highly expressed on venous valves mouse embryos, we tested hypothesis that mutations may linked reflux. Methods Results— The system leg was investigated with Duplex ultrasound. Pathological reflux recorded color ultrasound all 18 participants mutation,...
Abstract BACKGROUND. Obesity is considered a risk factor for the development of breast cancer‐related lymphedema arm and as poor prognostic in response to treatment. The objective this study was examine weight reduction treatment lymphedema. METHODS. Twenty‐one women with were randomized either receive dietary advice or booklet on general healthy eating. They monitored 12 weeks. RESULTS. primary outcome measure volume at results indicated significant swollen end 12‐week period ( P = .003)...
The prevalence of chronic arm oedema was determined among all 1249 women treated for breast cancer but without tumour recurrence and living registered in the Worthing District Health Authority area; 1151 (92%) responded to a validated questionnaire.The mean interval since treatment 9.5 years.Of 1077 unilateral cancer, 302 (28%) reported swelling.There significant (p = 0.01) increase with time patients who received post-operative radiotherapy.Overall, twice as common by radiotherapy (odds...
Mutations in vascular endothelial growth factor (VEGF) receptor-3 (VEGFR3 or FLT4) cause Milroy disease, an autosomal dominant condition that presents with congenital lymphedema. VEGFR3 are identified only 70% of patients classic suggesting genetic heterogeneity.To investigate the underlying clinical signs resembling disease whom sequencing coding region did not reveal any pathogenic variation.Exome 5 such was performed, and a novel frameshift variant, c.571_572insTT VEGFC, ligand for...
Cellulitis of the leg is a common bacterial infection skin and underlying tissue. We compared prophylactic low-dose penicillin with placebo for prevention recurrent cellulitis.