A5004898093- Lymphatic System and Diseases
- Integrated Energy Systems Optimization
- Global Energy Security and Policy
- Nuclear and radioactivity studies
- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Graphite, nuclear technology, radiation studies
- Hybrid Renewable Energy Systems
- Advanced Power Generation Technologies
- Systemic Sclerosis and Related Diseases
- Nuclear reactor physics and engineering
- Diagnosis and Treatment of Venous Diseases
- Dermatological and Skeletal Disorders
- Renewable energy and sustainable power systems
- Vehicle emissions and performance
- HVDC Systems and Fault Protection
- Cancer survivorship and care
- Advanced Aircraft Design and Technologies
- Turbomachinery Performance and Optimization
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Water-Energy-Food Nexus Studies
- Breast Cancer Treatment Studies
- Hair Growth and Disorders
- Superconducting Materials and Applications
- Health Systems, Economic Evaluations, Quality of Life
Guy's and St Thomas' NHS Foundation Trust
2012-2025
Saint Thomas West Hospital
2024
King's College London
1998-2024
Royal Children's Hospital
2024
Great Ormond Street Hospital for Children NHS Foundation Trust
2024
St Thomas' Hospital
2024
Louisiana State University at Eunice
2014
Nuffield Trust
2006
Broadway
2005
American Cancer Society
1998
Background: Lymphoedema/chronic oedema is an important cause of morbidity in the population, but little known its epidemiology and impact on patients or health services.
ABSTRACT The purpose of this study was to examine the use a number tools in evaluation health‐related quality life patients with lower limb lymphedema, and determine consequences cancer history concurrent leg ulceration. Patients one health trust having lymphedema were identified interviewed at entry after 24 weeks. short form‐36 (SF‐36), modified Barthel scale, McGill form pain questionnaire, Euroqol administered both time points. Of 164 (median age=76.9 years, 70.7% women) who comprised...
Abstract Background In recessive dystrophic epidermolysis bullosa (RDEB), complications like oesophageal strictures, hand contractures, cardiomyopathy and cutaneous squamous cell carcinoma (SCC) may develop, necessitating procedures such as dilatation (OD), gastrostomy tube placement surgery. Objectives To determine prevalence age of onset milestone events by RDEB subtype, specifically dysphagia, first OD, tube, surgery, cardiomyopathy, SCC death. Methods The Prospective Epidermolysis...
Abstract Background Itch is common and distressing in epidermolysis bullosa (EB) but has not previously been studied depth different recessive dystrophic EB (RDEB) subtypes. Objectives As part of a prospective register study the natural history RDEB we explored features itch, medications used, correlation with disease severity quality life. Methods Fifty individuals aged 8 years above completed Leuven Scale (LIS) (total 243 reviews over 7-year period). Data included itch frequency, severity,...
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare inherited skin fragility disorder requiring multidisciplinary management. Information regarding costs of current standard treatment scant.
A retrospective review of all head and neck cancer-related lymphoedema (HNCRL) referrals from 1 October 2009 to 30 September 2013 was undertaken. HNCRL significantly increased over a 4-year period. Lymphoedema clinic records were manually examined for the presentation HNCRL, treatments provided, outcomes. Some 207 received, increasing by 251% 2013. total 110 men 50 women assessed treated 4 years; 67% discharged, 26% continued treatment/monitoring clinic; 8% are deceased. The average time...
Breast cancer-related upper limb lymphoedema (BCRL) affects approximately 20 % of women undergoing axillary intervention. Women who attended a "reducing your risk lymphoedema" class, including exercise instruction, anecdotally reported positive BCRL outcomes. The aim this study was to examine outcomes and perceived benefit for attendees at class between 2000 2005. A cross-sectional conducted in two parts: (1) self-report questionnaire regarding status received from programme; (2) clinical...
<title>Abstract</title> <italic>Background</italic> Pain is common in the genetic skin fragility disorder epidermolysis bullosa (EB), from and mucosal injury inflammation as well extra-mucocutaneous sites. Individuals living with EB have identified pain a priority for better treatments. <italic>Objectives</italic> The Prospective Longitudinal Evaluation Study (PEBLES) prospective register study exploring natural history of RDEB across all ages birth to death. Here, we investigated...
Abstract All forms of the genetic skin fragility disorder recessive dystrophic epidermolysis bullosa (RDEB) are characterized by mucocutaneous blistering healing with scarring, although subtype severity, distribution and associated features correlate to underlying collagen VII genotype. Understanding natural history each distinct is key prognostication clinical management, for determining meaningful endpoints relevant trials emerging RDEB therapies. The Prospective Epidermolysis Bullosa...
Abstract Epidermolysis bullosa (EB) comprises a collection of rare skin fragility diseases characterized by mucocutaneous wounding from minimal trauma. For recessive dystrophic EB (RDEB), paucity detailed knowledge about symptom presentation, severity and progression throughout life, treatment resource use costs poses challenge for delivering robust clinical trials interpreting RDEB findings. The Prospective Longitudinal Evaluation Study (PEBLES) was established to explore the natural...
Abstract Epidermolysis bullosa (EB) comprises a collection of rare skin fragility diseases characterized by mucocutaneous wounding from minimal trauma. For recessive dystrophic EB (RDEB), paucity detailed knowledge about symptom presentation, severity and progression throughout life, treatment resource use costs poses challenge for delivering robust clinical trials interpreting RDEB findings. The Prospective Longitudinal Evaluation Study (PEBLES) was established to explore the natural...
Abstract All forms of the genetic skin fragility disorder recessive dystrophic epidermolysis bullosa (RDEB) are characterized by mucocutaneous blistering healing with scarring, although subtype severity, distribution and associated features correlate to underlying collagen VII genotype. Understanding natural history each distinct is key prognostication clinical management, for determining meaningful endpoints relevant trials emerging RDEB therapies. The Prospective Epidermolysis Bullosa...
Abstract Background Pain is common in the genetic skin fragility disorder epidermolysis bullosa (EB), from and mucosal injury inflammation as well extra-mucocutaneous sites. Individuals living with EB have identified pain a priority for better treatments. Objectives The Prospective Longitudinal Evaluation Study (PEBLES) prospective register study exploring natural history of RDEB across all ages birth to death. Here, we investigated characteristics treatment different subtypes. Methods...