A5074196854- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Gut microbiota and health
- Cardiac Ischemia and Reperfusion
- Pain Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Anesthesia and Sedative Agents
- Boron Compounds in Chemistry
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Cellular Mechanics and Interactions
- Dietary Effects on Health
- FOXO transcription factor regulation
- Cell death mechanisms and regulation
- Cancer Research and Treatments
- Alcohol Consumption and Health Effects
- Nerve injury and regeneration
- Ubiquitin and proteasome pathways
- Cardiomyopathy and Myosin Studies
- Fatty Acid Research and Health
- Organ Transplantation Techniques and Outcomes
- Signaling Pathways in Disease
Ningxia Medical University
2015-2025
Augusta University
2025
Augusta University Health
2024
Ningxia Medical University General Hospital
2015-2020
Chronic low-grade inflammation is regarded to an important signature of atherosclerosis (AS). Macrophage (Mψ) and related polarization have been demonstrated play a crucial role in the occurrence development AS inflammation. Butyrate, bioactive molecule produced by intestinal flora, has increasingly exhibit vital for regulating chronic metabolic diseases. However, effectiveness multiple anti-inflammation mechanisms butyrate on still need be further understood. ApoE −/− mice fed with high-fat...
The gut microbiome has been implicated in the development of cardiovascular disease (CVD) and atherosclerosis (AS), a chronic inflammatory condition. Aspirin may improve immuno-inflammatory status AS by regulating microbiota dysbiosis. However, potential role aspirin modulating microbial-derived metabolites remains less explored. In this study, we investigated effect treatment on progression apolipoprotein E-deficient (ApoE-/-) mice. We analyzed fecal bacterial targeted metabolites,...
Atherosclerosis (AS) is closely associated with abnormally chronic low-grade inflammation and gut dysbiosis. Flaxseed oil (FO) rich in omega-3 polyunsaturated fatty acids (PUFAs), which are mainly composed of alpha-linolenic acid (ALA, 18:3 omega-3), has been demonstrated to exhibit pleiotropic benefits metabolic diseases. However, the impact dietary ALA-rich FO on AS its underlying mechanisms remain poorly understood. Thus, present study was designed as two phases investigate effects...
Alcoholic liver disease (ALD) regarding to damage caused by alcohol abuse is characterized chronic inflammation, with dysregulations of the gut microbiota and its metabolites. Accumulating studies has demonstrated that butyrate exhibits pleitropic benefits in metabolic diseases. The present study was designed investigate effects mechanisms on ALD. In vivo, C57BL/6J mice were fed isocaloric modified Lieber-DeCarli liquid diets or without ethanol which supplemented sodium (NaB, 0.6 g/kg) for 6...
The aim of the present study was to investigate mechanism underlying rescue effect lipid emulsion on bupivacaine (BPV)‑induced cardiomyocyte toxicity. inhibitory effects BPV H9c2 myoblast cell proliferation were investigated using an MTT assay. cells treated with either 1 mM or 1% (LE) alone, co‑treated both drugs. Cell apoptosis detected Annexin V/propidium iodide staining and a terminal deoxynucleotidyl transferase dUTP protein expression levels apoptosis-associated proteins quantified...
Abstract Local anesthetics can cause severe toxicity when absorbed systemically. Rapid intravenous administration of lipid emulsion (LE) is the standard care for local anesthetic systemic which cardiovascular and central nervous system (CNS) injury. The biological mechanism by LE alleviates CNS remains unknown understudied. Previous research has suggested that an imbalance excitatory inhibitory transmission in brain. Therefore, this study aimed to observe effect on glutamate‐ GABA‐induced...
Abstract Dysfunction in either embryonic or postnatal vascular smooth muscle cells (SMCs) significantly contributes to the progression of various cardiovascular diseases. Therefore, elucidating molecular mechanisms governing VSMC development and homeostasis is crucial. MYH11 most reliable lineage gene for SMCs has been utilized develop tamoxifen-inducible Cre driver lines achieving SMC-specific manipulation by crossing with mice carrying lox P -flanked gene, particularly adult mice. For...
Abstract Objective To compare the effectiveness and safety of central venous catheter thoracic drainage (CVCTD) with traditional closed (TCTD) after minimally invasive surgery for esophageal cancer. Methods We conducted a retrospective investigation 103 patients who underwent cancer at our institution between January 2017 December 2019. Among them, 44 CVCTD, while 59 received TCTD. compared following outcomes two cohorts: volume, duration drainage, postoperative complications (including...
The authors have withdrawn their manuscript because the article needs to supplement data of cell culture clarify mechanism. Therefore, do not wish this work be cited as reference for project. If you any questions, please contact corresponding author.
Objective To investigate the effect of lipid emulsion on mitochondrial energy metabolism during bupivacaine-induced myocardiotoxicity in rats. Methods H9c2 cells were inoculated 96-well plates at a density 1×105 cells/ml, and randomly divided into 4 groups(n=18 each)using random number table: control group(group C), bupivacaine B), LE), + B+ LE). The incubated normal culture medium group C. In LE, containing 1% emulsion.In B, 1 mmol/L bupivacaine.In emulsion.After 24 h incubation,...
Objective To evaluate the effect of mitochondrial permeability transition pore(mPTP)in lipid emulsion-induced inversion bupivacaine myocardiotoxicity in rats. Methods H9c2 cells were inoculated 6-well plates at a density 105 cells/ml, and randomly divided into 4 groups(6 wells each group, 2 ml/well)using random number table: control group(group C), B), emusion+ LB), bupivacaine+ atractyloside LBA). Phosphate buffer solution 100 μl was added to culture medium group C. In B, with final...
Abstract Bupivacaine (BPV) can cause severe central nervous system toxicity when absorbed into the blood circulation system. Rapid intravenous administration of lipid emulsion (LE) could be used to treat local anaesthetic toxicity. This study aimed investigate mechanism by which BDNF-TrkB/proBDNF-p75 NTR pathway regulation LE rescues BPV induced neurotoxicity in hippocampal neurons rats. Seven- nine-day-old primary cultured were randomly divided 6 groups: blank control group (Ctrl),...
Objective To evaluate the role of glycogen synthase kinase 3 beta (GSK-3β) in lipid emulsion-induced inhibition bupivacaine-induced apoptosis cardiomyocytes rats using RNA interference (RNAi) adenovirus infection method. Methods H9C2 cells were transferred into 96-well cell plates at a density 1×105 cells/ml after culture and then divided 8 groups (n=10 each) random number table: control group (group C), bupivacaine B), emulsion LE), plus B+ GSK-3βRNAi (GSK-3βi) C+ GSK-3βi), GSK-3βi...
Abstract Objective: To evaluate the clinical safety and practicability of closed thoracic drainage device after esophageal cancer surgery, so as to reduce postoperative pain shorten length hospital stay,speed up recovery patients. Methods: A retrospective analysis patients who underwent minimally invasive surgery for in Second Department Surgery, General Hospital Ningxia Medical University from January 2017 December 2019. Among them, 44 59 central venous catheter traditional drainage,...