A5076389889- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Statistical Methods in Clinical Trials
- Reproductive Biology and Fertility
- Mental Health Treatment and Access
- Silicon and Solar Cell Technologies
- Schizophrenia research and treatment
- Advanced Statistical Methods and Models
- Statistical Distribution Estimation and Applications
- Bayesian Methods and Mixture Models
- Gene expression and cancer classification
- earthquake and tectonic studies
- Geotechnical Engineering and Soil Mechanics
- Ovarian function and disorders
- Financial Risk and Volatility Modeling
- Quantum Dots Synthesis And Properties
- BRCA gene mutations in cancer
- Healthcare and Venom Research
- Geotechnical Engineering and Soil Stabilization
- Geotechnical Engineering and Underground Structures
- RNA and protein synthesis mechanisms
- Mental Health and Psychiatry
- Radio Astronomy Observations and Technology
- Radioactivity and Radon Measurements
- Thin-Film Transistor Technologies
China University of Geosciences
2023-2024
National Taiwan University
2010-2022
Institute of Statistical Science, Academia Sinica
2008-2022
Academia Sinica
1991-2020
Taipei Medical University Hospital
2011
Institute of Atomic and Molecular Sciences, Academia Sinica
2011
National Taiwan University Hospital
2006
China Medical University
2002
Duke University Hospital
1995
Duke Medical Center
1995
A model is proposed for the analysis of censored data which combines a logistic formulation probability occurrence an event with proportional hazards specification time event. The semiparametric generalization parametric due to Farewell (1982). Estimates regression parameters are obtained by maximizing Monte Carlo approximation marginal likelihood and EM algorithm used estimate baseline survivor function. We present some simulation results verify validity suggested estimation procedure. It...
Abstract Background The development of microarrays permits us to monitor transcriptomes on a genome-wide scale. To validate microarray measurements, quantitative-real time-reverse transcription PCR (Q-RT-PCR) is one the most robust and commonly used approaches. new challenge in gene quantification analysis how explicitly incorporate statistical estimation such studies. In realm analysis, various available methods probe level normalization for may result distinctly different target selections...
Abstract This paper describes the use of bootstrap, 1,2 a new computer‐based statistical methodology, to help validate regression model resulting from fitting Cox's proportional hazards 3 set censored survival data. As an example, we define prognostic for outcome in childhood acute lymphocytic leukemia with Cox and training 224 patients. To accuracy model, bootstrap resampling technique mimic population under study two stages. First, select important factors via stepwise procedure 100...
The nuclease activity of 1,10-phenanthroline-copper ion can be targeted to specific DNA sequences by attachment the ligand 5' end complementary deoxyoligonucleotides via a phosphoramidate linkage. To synthesize adduct, phosphorimidazolide deoxyoligonucleotide is prepared using water-soluble carbodiimide and then coupled 5-glycylamido-1,10-phenanthroline. After hybridization target DNA, sequence-specific cleavage observed upon addition cupric 3-mercaptopropionic acid. Two methods assaying...
We have previously reported that synthetic peptides representing the leucine zipper domain (DP107) and a second putative helical (DP178) of human immunodeficiency virus type 1 (HIV-1) gp41 exhibit potent anti-HIV activity. In this study we used soluble recombinant forms to provide evidence DP178 peptide region associate with distal site on transmembrane protein whose interactive structure is influenced by motif. also observed single coiled-coil-disrupting mutation in transformed from an...
PURPOSE To evaluate prospectively the efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) in reduction chemotherapy-induced oral mucositis. PATIENTS AND METHODS Twenty patients with stage IV squamous cell carcinoma head and neck were studied. Two-cycles (periods) identical doses cisplatin, fluorouracil (5-FU), leucovorin (PFL) chemotherapy cisplatin 20 mg/m2/d, 5-FU 800 90 mg/m2/d by 96-hour continuous intravenous infusion every 3 weeks given to each patient. After PFL...
The effectiveness of acupuncture in acute stroke remains largely untested and unproved. A randomized, controlled trial was carried out to study the feasibility combination with conventional supportive treatment for patients. total 30 patients, aged 46-74, onset symptoms within 36 h were enrolled into after appropriate screening. All patients gave informed consent. Basing on same treatment, randomly assigned a or without acupuncture. procedure acupoint selection discussed decided through...
To confirm an impression that many survivors of acute lymphoblastic leukemia (ALL) are overweight or obese, we retrospectively examined the medical records 414 patients for height and weight at diagnosis, completion treatment, annual intervals thereafter. The body mass index, weight/height2, was used as a measure fatness; population norms index were established from 9,003 people between ages 1 30 years who in national health survey. percentile each patient's determined observation date. At...
The clinical features and metabolic complications of polycystic ovary syndrome (PCOS) may change with age. This study was designed to investigate the biochemical characteristics PCOS patients between ages 20 40. included 781 Taiwanese women, whom 453 were diagnosed 328 non-PCOS controls. Anthroponmetric components, androgens, endocrine, insulin resistance, components measured correlated Above parameters compared younger elder women PCOS. Age had significant negative correlations androgens...
Background: Serum uric acid (SUA) has gradually been recognized as a potential risk factor for cardiovascular disease (CVD). However, whether the relationship is causal remains controversial. Methods: We employed two methods to demonstrate importance of SUA in CVD development. First, we examined onset sequence hyperuricemia relation five cardiometabolic (CM) diseases. Second, conducted Mendelian randomization (MR) study causally infer between and CVD. The information collected from...
The long-term effects of metformin in women with polycystic ovarian syndrome (PCOS) are inadequately studied. on PCOS during 24 months respect to menses, hormones, and metabolic profiles assessed. Prospective cohort. A reproductive endocrinology clinic a university-affiliated medical center. One hundred nineteen PCOS, defined by the Rotterdam criteria, were enrolled. Metformin was given daily for months. primary outcome proportion patients regular menstruation treatment. Changes...
The present study aimed to investigate the association between serial serum alanine aminotransferase (ALT) and spontaneous hepatitis B e antigen (HBeAg) seroconversion age in chronic virus (HBV)-infected children.
The optical properties of type-II $\mathrm{In}\mathrm{As}∕\mathrm{Ga}{\mathrm{As}}_{0.7}{\mathrm{Sb}}_{0.3}$ quantum dots (QDs) were investigated by photoluminescence (PL). It is found that the peak position PL spectra exhibits a significant blueshift under moderate excitation level. observed can be well explained band bending effect due to spatially separated photoexcited carriers in alignment. We also exhibit strong in-plane polarization with degree up 24%. anisotropy attributed inherent...
Background The effectiveness of large-scale interventions to prevent suicide among persons who previously attempted remains be determined. National Suicide Surveillance System (NSSS), launched in Taiwan 2006, is a structured nationwide intervention program for people survived their attempts. This naturalistic study examined its using data from the first 3 years operation. Method Effectiveness NSSS aftercare services was logistic/proportional odds mixture model, with eventual as outcome...
Although the function of BRCA1 gene has been extensively studied, relationship between expression and tumor aggressiveness remains controversial in sporadic breast cancers. Because protein is known to regulate estrogen signaling, we selected microarray data ER+ cancers from GEO public repository resolve previous conflicting findings. The level highly proliferative luminal B tumors was shown be higher than that A tumors. Survival analysis using a cure model indicated patients early with high...
Using data samples collected with the BESIII detector operating at BEPCII storage ring, cross section of inclusive process e^{+}e^{-}→η+X, normalized by total e^{+}e^{-}→hadrons, is measured eight center-of-mass energy points from 2.0000 to 3.6710 GeV. These are first measurements momentum dependence in this region. Our measurement shows a significant discrepancy compared existing fragmentation functions. To address discrepancy, new QCD analysis performed next-to-next-to-leading order hadron...