A5100669330- Acute Myeloid Leukemia Research
- 3D Printing in Biomedical Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Microfluidic and Bio-sensing Technologies
- Hepatitis B Virus Studies
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Viral Infections and Vectors
- Toxic Organic Pollutants Impact
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- Innovative Microfluidic and Catalytic Techniques Innovation
- Epigenetics and DNA Methylation
- Bone Tumor Diagnosis and Treatments
- Cancer-related gene regulation
- Microfluidic and Capillary Electrophoresis Applications
- Pancreatic function and diabetes
Wenzhou Medical University
2019-2025
Zhoushan Hospital
2012-2025
Tongji University
2025
Tianjin Normal University
2024
Zhejiang University
2024
Jinan University
2024
University of Oklahoma Health Sciences Center
2012-2023
University of Science and Technology of China
2017-2023
Shenzhen Institutes of Advanced Technology
2023
Chinese Academy of Sciences
2023
Abstract Objective To study the clinical characteristics of patients in Zhejiang province, China, infected with 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for disease (covid-2019). Design Retrospective case series. Setting Seven hospitals China. Participants 62 admitted to hospital laboratory confirmed SARS-Cov-2 infection. Data were collected from 10 January 2020 26 2020. Main outcome measures Clinical data, using a standardised report form, such as...
Abstract Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that predominantly affects women. Despite isolated reports of patients with coexisting Klinefelter's syndrome (47,XXY) and SLE, no association SLE or any other has been established. The present study was undertaken to investigate the prevalence in large population SLE. Methods Sex chromosome genotyping performed 981 patients, whom 213 were men. A first group 844 from 378 multiplex families second 137 men...
Objective More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts this, and we undertook study to test our hypothesis trisomy (47,XXX; occurring in ∼1 1,000 live births) would be increased patients with female‐predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], biliary cirrhosis, rheumatoid arthritis [RA]) compared without...
Conductive flexible hydrogels have attracted immense attentions recently due to their wide applications in wearable sensors. However, the poor mechanical properties of most conductive polymer limit utilizations. Herein, a double network hydrogel is fabricated via self-sorting process with cationic polyacrylamide as first and lantern[3
Although various liver chips have been developed using emerging organ-on-a-chip techniques, it remains an enormous challenge to replicate the lobules with self-assembled perfusable hepatic sinusoid networks. Herein we develop a lifelike bionic lobule chip (LLC), on which networks are achieved microflow-guided angiogenesis methodology; additionally, during and after self-assembly, oxygen concentration is regulated mimic physiologically dissolved levels supplied by actual arterioles venules....
Abstract Loss of heterozygosity (LOH) was examined at 27 loci on chromosomes 3p, 6q, 11p, 13q, 17 and X in 42 human ovarian tumors. LOH detected 12 26 (46%) 5 (42%) informative cases 2 chromosome 13q loci, D13S32 D13S34 respectively. On Xp, tumor‐specific allele loss observed 9 out 15 (60%) the ornithine transcarbamylase (OTC) gene locus. Examination additional Xp has mapped common deletion regions to Xp21.1 → p11.4 13q33 q34. The observation significant represents a strong indication...
Abstract Aim: To determine the rate of Klinefelter’s syndrome among men with systemic lupus erythematosus (SLE), and to whether manifestations SLE in these are different from that seen 46,XY men. Methods: A total 276 underwent a real‐time PCR procedure screen for more than one X chromosome. Those results consistent two chromosomes were further characterized by karyotype FISH. Clinical determined interview, questionnaire medical chart review. Each man was matched four SLE. Rates compared...
Objective Sjögren's syndrome ( SS ) and systemic lupus erythematosus SLE are related by clinical serologic manifestations as well genetic risks. Both diseases more commonly found in women than men, at a ratio of ~10 to 1. Common X chromosome aneuploidies, 47, XXY XXX , enriched among men women, respectively, either disease, suggesting dose effect on the chromosome. Methods We examined cohorts patients constructing intensity plots single‐nucleotide polymorphism alleles, along with determining...
Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (HCC) progression remain insufficiently elucidated. We identified circUCK2(2,3) through circRNA sequencing, RT-PCR, Sanger sequencing. CircUCK2(2,3) levels were measured two independent HCC cohorts using quantitative real-time PCR (qRT-PCR). explored functions gain-...
Telomere in cancers shows a main impact on maintaining chromosomal stability and unlimited proliferative capacity of tumor cells to promote cancer development progression. So, we targeted detect telomere-related genes(TRGs) hepatocellular carcinoma (HCC) develop novel predictive maker response immunotherapy. We sourced clinical data gene expression datasets HCC patients from databases including TCGA GEO database. The TelNet database was utilized identify genes associated with telomeres....
Chronic hepatitis B (CHB) patients who have sustained virological suppression (SVS) still develop hepatocellular carcinoma(HCC), and the risk factors for developing HCC in these are not fully understood. This study included a total of 5234 achieved SVS. After SVS, incidence rate was 1.9% 1-8 years 1.33% 9-16 years. There significant difference between two periods (P < 0.001). after multivariate analysis IPTW adjustment, related to occurrence were men, hypertensive patients, diabetes high...
Cancer is a multistep progressive disease that generally involves tumor growth, invasion, and metastasis. It crucial to understand progression for diagnosis therapy. However, at an extremely early stage (EES) barely demonstrated because EES tumors are too small be detected by imaging. Herein, we, the first time, replicated on microfluidic chip uncovered behaviors affected microenvironment. To mimic of single solid EES, HeLa cell spheroid was seeded cultured chip, microvascular network...
Hepatic sinusoids play a key role in maintaining high activities of liver cells the hepatic acinus. However, construction has always been challenge for chips, especially large-scale microsystems. Herein, we report an approach sinusoids. In this approach, are formed by demolding self-developed microneedle array from photocurable cell-loaded matrix liver-acinus-chip microsystem with designed dual blood supply. Primary demolded microneedles and spontaneously self-organized secondary can be...
A stable diffuse large-volume air plasma source was developed by using argon-induced dielectric-barrier discharges at atmospheric pressure. This can be operated in a filamentary discharge with the average areal power density of 0.27 W/cm2 and gas temperature 315±3 K. Spatial measurement emission spectrum indicates that this is uniform central region along transverse direction. It also found formation mainly lies creation sufficient seed electrons Penning effect through collisions between two...
The treatment of familial hyperchylomicronemia presenting in early childhood with episodes pancreatitis has been ineffective, and affected patients remain at risk for pancreatitis.To report on the effect orlistat siblings severe inherited to assess posttreatment lipoprotein concentrations composition.Serial observations plasma lipid levels hospitalizations after studies a single fasting sample.The lipase gene mutation from each their parents: novel father (c.542G > C, p.G181R) known missense...
As liver biopsy has considerable limitations in the assessment of fibrosis, non-invasive models have achieved great progress past. However, many tests consist variables that are not readily available, and there few data about patients with hepatitis B e-antigen (HBeAg) negative chronic (CHB). The aim this study was to develop a model using routine predict fibrosis HBeAg CHB patients.We randomly divided 349 who underwent into training (n = 200) validation 149) sets. Multivariable logistic...