A5044610420- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Proteoglycans and glycosaminoglycans research
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- ATP Synthase and ATPases Research
- Wastewater Treatment and Nitrogen Removal
- Mine drainage and remediation techniques
- RNA Research and Splicing
- Acute Myeloid Leukemia Research
- Cellular Mechanics and Interactions
- Minerals Flotation and Separation Techniques
- Soil Carbon and Nitrogen Dynamics
- Metal Extraction and Bioleaching
- Caveolin-1 and cellular processes
- Heavy Metal Exposure and Toxicity
- Circular RNAs in diseases
- Cancer-related gene regulation
- Coagulation and Flocculation Studies
- Cancer Mechanisms and Therapy
- Dermatological and COVID-19 studies
- Recycled Aggregate Concrete Performance
- Probability and Risk Models
Shanghai University of Medicine and Health Sciences
2021-2025
Southern University of Science and Technology
2018-2023
Nanjing Agricultural University
2012-2023
University Hospital Heidelberg
2021
Heidelberg University
2020-2021
Janssen (United States)
2021
North China University of Technology
2018
Shanghai Medical College of Fudan University
2010-2017
Martin Luther University Halle-Wittenberg
2015
Hebei Agricultural University
2009-2011
The biological significance of a known normal and cancer stem cell marker CD133 remains elusive. We now demonstrate that the phosphorylation tyrosine-828 residue in C-terminal cytoplasmic domain mediates direct interaction between phosphoinositide 3-kinase (PI3K) 85 kDa regulatory subunit (p85), resulting preferential activation PI3K/protein kinase B (Akt) pathway glioma (GSC) relative to matched nonstem cell. knockdown potently inhibits activity PI3K/Akt with an accompanying reduction...
Abstract Cell metabolism is strongly influenced by mechano-environment. We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), key enzyme for proline synthesis. Extracellular matrix (ECM) stiffening promotes translocation into its interaction PYCR1, resulting in elevation PYCR1 level consequent increase synthesis cell proliferation. Depletion reduces level, increases reactive oxygen species (ROS) production...
Precise control of mesenchymal stem cell (MSC) differentiation is critical for tissue development and regeneration. We show here that kindlin-2 a key determinant MSC fate decision. Depletion in MSCs sufficient to induce adipogenesis inhibit osteogenesis vitro vivo. Mechanistically, regulates through controlling YAP1/TAZ at both the transcript protein levels. Kindlin-2 physically associates with myosin light-chain kinase response mechanical cues microenvironment intracellular signaling events...
Reprograming of proline metabolism is critical for tumor growth. Here we show that PINCH-1 highly expressed in lung adenocarcinoma and promotes synthesis through regulation mitochondrial dynamics. Knockout (KO) increases dynamin-related protein 1 (DRP1) expression fragmentation, which suppresses kindlin-2 translocation interaction with pyrroline-5-carboxylate reductase (PYCR1), resulting inhibition cell proliferation. Depletion DRP1 reverses deficiency-induced defects on dynamics,...
Tea plant is an economically important crop in China, but long-term monoculture and substantial chemical nitrogen fertilizer input cause soil acidification, which turn affects the nutrient supply tea quality. Intercropping has drawn more attention gardens because this pattern expected to improve fertility quality change microbial community composition. However, roles of some key microorganisms rhizosphere soils have not been well characterized. Hereby, a "soybean summer smooth vetch winter"...
Abstract Non-small cell lung cancer (NSCLC) is the leading cause of death worldwide underlining urgent need for new biomarkers and therapeutic targets this disease. Long noncoding RNAs are critical players in NSCLC but role small RNA species not well understood. In present study, we investigated H/ACA box nucleolar (snoRNAs) snoRNA-bound ribonucleoproteins (snoRNPs) tumorigenesis NSCLC. snoRNPs including NOP10 core protein were highly expressed High levels either mRNA or associated with poor...
Immunotherapies, such as chimeric antigen receptor (CAR) modified T cells and antibody-drug conjugates (ADCs), have revolutionized the treatment of cancer, especially lymphoid malignancies. The application targeted immunotherapy to patients with acute myeloid leukemia (AML) has been limited in particular by lack a tumor-specific target antigen. Gemtuzumab ozogamicin (GO), an ADC targeting CD33, is only approved immunotherapeutic agent AML. In our study, we introduce CD33-directed...
Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (HCC) progression remain insufficiently elucidated. We identified circUCK2(2,3) through circRNA sequencing, RT-PCR, Sanger sequencing. CircUCK2(2,3) levels were measured two independent HCC cohorts using quantitative real-time PCR (qRT-PCR). explored functions gain-...
CD133 is widely used as a marker for the isolation and characterization of normal cancer stem cells. The dynamic alternation glycosylation contributes to cells, supposed be associated with cell differentiation. Although has been identified N-glycosylated protein, specific status remain unclear. Here, we found that could sialylated in neural cells glioma-initiating sialyl residues attach N-glycan terminal via α2,3-linkage. Furthermore, desialylation by neuraminidase specifically accelerates...
// Ying Liu 1,* , Shifang Ren Liqi Xie 2 Chunhong Cui 1 Yang Xing Chanjuan Benjin Cao Fan Yinan Li Xiaoning Chen Yuanyan Wei Haojie Lu and Jianhai Jiang Key Laboratory of Glycoconjuates Research, Ministry Public Health Gene Research Center, Department Biochemistry Molecular Biology, Shanghai Medical College Fudan University, Shanghai, People's Republic China Institutes Biomedical Sciences * These authors have contributed equally to this work Correspondence to: Jiang, email: Lu, Wei, Keywords...
Pulmonary fibrosis is a progressive and fatal lung disease characterized by activation of fibroblasts excessive deposition collagen matrix. We show here that the concentrations kindlin-2 its binding partner PYCR1, key enzyme for proline synthesis, are significantly increased in tissues human patients with pulmonary fibrosis. Treatment TGF-β1 markedly expression resulting mitochondrial translocation, formation kindlin-2–PYCR1 complex, synthesis. The complex synthesis were reduced response to...
The estimation of a postmortem interval (PMI) is particularly important for forensic investigations. aim this study was to assess the succession bacterial communities associated with decomposition mouse cadavers and determine most biomarker taxa estimating PMIs. High-throughput sequencing used investigate gravesoil samples different PMIs, random forest model identify taxa. Redundancy analysis significance environmental factors that were related communities. Our data showed relative abundance...
Relapse of acute myeloid leukemia (AML) has a very poor prognosis and remains common cause treatment failure in patients with this disease. AML relapse is partially driven by the chemoresistant nature stem cells (LSCs), which poorly understood, our study aimed at elucidating underlying mechanism. Accumulating evidences show that long noncoding RNAs (lncRNAs) play crucial role development. Herein, lncRNA, LINC00152, was identified to be highly expressed CD34
Malignant glioblastoma multiforme is one of the most aggressive human cancers, with very low survival rates. Recent studies have reported that glioma stem-like cells transdifferentiate into endothelial cells, indicating a new mechanism for tumor angiogenesis and potentially providing therapeutic options treatment. Glioma malignancy strongly associated altered expression N-linked oligosaccharide structures on cell surface. We previously β1,4-galactosyltransferase V (β1,4GalTV), which...
The feasibility of removing heavy metals and eliminating pathogens from pig slurry through bioleaching involving the fungus Galactomyces sp. Z3 two acidophilic thiobacillus (A. ferrooxidans LX5 A. thiooxidans TS6) was investigated. It found that isolated dissolved organic matter (DOM) degrader identified as Z3, which could grow well at pH 2.5–7 degrade DOM 1973 to 942 mg/l within 48 h. During successive multi-batch systems, co-inoculation Acidithiobacillus species improve efficiency compared...