A5100405824- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Advanced Sensor and Energy Harvesting Materials
- Cell Adhesion Molecules Research
- Micro and Nano Robotics
- Ion channel regulation and function
- Metabolism and Genetic Disorders
- 3D Printing in Biomedical Research
- Epilepsy research and treatment
- Cancer, Hypoxia, and Metabolism
- Pluripotent Stem Cells Research
- Advanced Polymer Synthesis and Characterization
- Polymer composites and self-healing
- Ubiquitin and proteasome pathways
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- Ionic liquids properties and applications
- Metabolomics and Mass Spectrometry Studies
- Soft Robotics and Applications
- Cancer Treatment and Pharmacology
- Adhesion, Friction, and Surface Interactions
- Conducting polymers and applications
- Lipoproteins and Cardiovascular Health
- Hydrogels: synthesis, properties, applications
Southern University of Science and Technology
2020-2023
Peking University Shenzhen Hospital
2021
Imperial College London
2014
Knopp Biosciences (United States)
2014
Marine Biological Laboratory
2014
University of Chieti-Pescara
2014
Huazhong University of Science and Technology
2014
Yale University
2014
Second Affiliated Hospital of Nanjing Medical University
2010-2012
Zhejiang University
2011
Abstract Hydrogels are a widely used ionic conductor in on-skin electronic and iontronic devices. However, hydrogels dehydrate the open air freeze at low temperatures, limiting their real applications when they attached on skin or exposed to temperatures. Polymer-ionic liquid gels can overcome these two obstacles, but synthetic liquids expensive toxic. In this work, we present an based polyacrylic acid (PAAc) deep eutectic solvents (DESs) that well addresses aforementioned challenges. We...
Reprograming of proline metabolism is critical for tumor growth. Here we show that PINCH-1 highly expressed in lung adenocarcinoma and promotes synthesis through regulation mitochondrial dynamics. Knockout (KO) increases dynamin-related protein 1 (DRP1) expression fragmentation, which suppresses kindlin-2 translocation interaction with pyrroline-5-carboxylate reductase (PYCR1), resulting inhibition cell proliferation. Depletion DRP1 reverses deficiency-induced defects on dynamics,...
Inefficiency of oxidative phosphorylation can result from futile leak conductance through the inner mitochondrial membrane. Stress or injury may exacerbate this conductance, putting cells, and particularly neurons, at risk dysfunction even death when energy demand exceeds cellular production. Using a novel method, we have recently described an ion consistent with permeability transition pore (mPTP) within c-subunit ATP synthase. Excitotoxicity, reactive oxygen species–producing stimuli,...
Direct-ink-write (DIW) printing has been used in myriad applications. Existing DIW relies on inks of specific rheology to compromise with process, imposing restrictions the choice printable materials. Reported ink viscosity ranges from 10−1 103 Pa·s. Here we report a method enable that is compatible dilute (10−3 Pa·s) by manipulating interactions between and substrate. By exemplifying hydrogel printing, build system show appropriate surface energy, once extruded, can spontaneously wet reside...
Hypoxia-inducible factor 1α (HIF-1α) plays pivotal roles in maintaining pluripotency, and the developmental potential of pluripotent stem cells (PSCs). However, mechanisms underlying HIF-1α regulation neural cell (NSC) differentiation human induced (hiPSCs) remains unclear. In this study, we demonstrated that knockdown significantly inhibits pluripotency self-renewal hiPSCs. We further uncovered disruption promotes NSC development vitro vivo . Mechanistically, enhances mitofusin2...
Pulmonary fibrosis is a progressive and fatal lung disease characterized by activation of fibroblasts excessive deposition collagen matrix. We show here that the concentrations kindlin-2 its binding partner PYCR1, key enzyme for proline synthesis, are significantly increased in tissues human patients with pulmonary fibrosis. Treatment TGF-β1 markedly expression resulting mitochondrial translocation, formation kindlin-2–PYCR1 complex, synthesis. The complex synthesis were reduced response to...
Adhesives are ubiquitous, but the mutual exclusion between hyperelasticity and adhesiveness impedes their uses in emerging techniques such as flexible/stretchable electronics. Herein, we propose a strategy to synthesize hyperelastic adhesives (HEAs), by designating bulk surface of polymer network, respectively. The is nonadhesive, viscoelastic adhesive, while HEA adhesive. We exemplify principle synthesizing poly(butyl acrylate) acrylate-co-isobornyl surface. resulting exhibits low...
Abstract Soft shells are ubiquitous in soft devices, e.g., robots, wearable sensors, and medial replicas. However, previous widely accepted methods, such as mold casting, dip coating, additive manufacturing, limited to thick due the assembly large friction during demolding, long processing time for dissolution, poor scalability, respectively. Here, a facile, robust, scalable manufacturing technique, named flow create with complex geometries multifunctionalities is proposed. The method...
To determine the mechanisms involved in regulating balance between apoptosis and survival vascular smooth muscle cells (VSMC), we studied anti-apoptotic stimuli that can counteract pro-apoptotic events process of early atherosclerotic lesions formation. Such a involves VSMC accumulation even presence oxidized low density lipoprotein (Ox-LDL). In arch aorta, find integrin β3 is higher than descending arteries. advanced atherosclerosis lesion, found an inverse correlation level...
As the first version of synthetic hydrogel, poly(2-hydroxyethyl methacrylate) hydrogels have found broad applications. However, their poor mechanical performances been long-standing hurdles for practical deployments. Herein, we report on strengthening with biochar nanoparticles and hydrophobic aggregations, which are induced by solvent exchange reinforced freeze-thaw. Both vast anchoring points multifunctional surfaces aggregates formed between chains engender strong dissipative physical...
Abstract: Mitochondrial DNA (mtDNA) haplogroup discrimination is interesting not only for phylogenetic and clinical but also forensic studies. We discriminated the mtDNA haplogroups of 570 healthy unrelated Han people from Zhejiang Province, Southeast China, by comprehensive analysis mutations hypervariable segments-I sequence diagnostic polymorphisms in coding region using real-time polymerase chain reaction (RT-PCR), which was compared with widely used PCR restriction fragment length...
Due to the complicated clinical features of mitochondrial encephalomyopathy, simplified disease criteria (MDC) have recently been established in Europe. This study evaluated sensitivity and specificity this scoring system Chinese patients. Seventy-eight patients with suspected encephalomyopathy were recruited be scored by MDC further classified into "possible" (2-4), "probable" (5-7), or "definite" categories (≥8). Significant differences observed between total scores group other myopathy...
Background : Neural damage can be mitigated by calcium-channel blockers (CCBs). However, the mechanism of action CCBs is not yet fully understood. Objective To investigate and efficacy CCB, flunarizine in restoring neural function after crush injury to nerves Materials Methods The sciatic rats were crushed using pincers establish model for injury. Two hundred eighty-eight Sprague-Dawley (SD) randomly divided into sham-operated, saline, low-dose high-dose (FI FII) groups. expression protein...
<b>Objectives:</b> To study the effect of Buflomedil on morphological repair crush injury sciatic nerve and also expression vascular endothelial growth factor (VEGF).<br> <b>Materials Methods:</b> Rat nerves were crushed by pincers. All 400 Sprague Dawley rats randomly divided into: Sham-operated; saline; saline + VEGF-antibody; Buflomedil; VEGF antibody groups. The in dorsal root ganglia (DRGs), following to nerves, was studied RT-PCR, immunohistochemistry. effects neural pathology...