A5042486521- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- ATP Synthase and ATPases Research
- Alzheimer's disease research and treatments
- Radiomics and Machine Learning in Medical Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Histone Deacetylase Inhibitors Research
- Neurological and metabolic disorders
- Glycogen Storage Diseases and Myoclonus
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Bayesian Modeling and Causal Inference
- Infectious Encephalopathies and Encephalitis
- Neurogenetic and Muscular Disorders Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Congenital heart defects research
- Collagen: Extraction and Characterization
- Chromatin Remodeling and Cancer
- Advanced X-ray and CT Imaging
- Glioma Diagnosis and Treatment
- Aluminum toxicity and tolerance in plants and animals
- Mechanisms of cancer metastasis
- NF-κB Signaling Pathways
- Body Composition Measurement Techniques
Nanjing Drum Tower Hospital
2014-2025
Nanjing Medical University
2008-2021
Kaiser Permanente
2021
Nanjing University
2020
Southeast University
2016
State Key Laboratory of Digital Medical Engineering
2016
Many modalities of magnetic resonance imaging (MRI) have been confirmed to be great diagnostic value in glioma grading. Contrast enhanced T1-weighted allows the recognition blood-brain barrier breakdown. Perfusion weighted and MR spectroscopic enable quantitative measurement perfusion parameters metabolic alterations respectively. These can potentially improve grading process if combined properly. In this study, Bayesian Network, which is a powerful flexible method for probabilistic analysis...
The purpose of this study is to investigate the possible mechanism and neuroprotective effect human urinary kallidinogenase (HUK) in cerebral ischemia. mouse middle artery occlusion (MCAO) model was used. Mice were treated with HUK (20 PNAU/g per day, intravenous) or saline as control, from beginning reperfusion 72 h. Neurological deficits, infarct size, BWC measured at 6, 24, 48, h after MCAO, respectively. Pathological changes brain observed by TUNEL assay. Inflammatory factors real-time...
<title>Abstract</title> <bold>Background</bold> Primary central nervous system plasmablastic lymphoma (PCNSPBL) represents an exceptionally rare and aggressive subtype of diffuse large B-cell (DLBCL), characterized by its distinct immunophenotypic profile predilection for immunocompromised individuals. Accurate preoperative diagnosis remains challenging due to the nonspecific radiological features observed on conventional magnetic resonance imaging (MRI), necessitating comprehensive...
Rationale and ObjectivesHomozygous deletion (HD) of CDKN2A/B holds important prognostic value in gliomas. This study aimed to explore the predictive potential conventional MRI characteristics combined with dynamic contrast-enhanced parameters predicting HD status gliomas.Materials MethodsPreoperative data 105 patients (69 without HD, 36 homozygous deletion) gliomas were retrospectively collected. Conventional features contrast-enhanced-MRI qualitative parameter time-intensity curve type,...
Sous Vide (SV) is a potential meat thermal processing technology. However, the texture evolution of SV processed not easy to understand due complex hierarchical structure meat. In our research, two-level colloidal model was carried out analyze SV-processed Tibetan chicken breast. Moreover, electromyography analysis used collaborate results between human sensory evaluation and machine detection. Although denaturation dehydration sub-continuous phase cytoskeletal proteins are unavoidable even...
Histone deacetylases (HDAC) inhibitors have been emerging as neuroprotective agents by acting on neurons and microglia. In this study, we found trichostatin A (TSA), a HDAC inhibitor, could inhibit the elevation of glutamate in 150 μM 1-methyl-4-phenylpyridinium (MPP+)-treated primary cultured astrocytes medium when its concentration reached 132 nM. TSA nM or more promote uptake [3H]-D, L-glutamate astrocytes. Further study showed downregulation transporter 1 glutamate/aspartate induced MPP+...
Alzheimer's disease (AD) is the most common form of dementia that primarily characterized by progressive cognitive deficits. The toxicity amyloid β‑protein (Aβ) serves an important role in progression AD, resulting neuronal loss via a number possible mechanisms, including oxidative stress, mitochondrial dysfunction, energy depletion, apoptosis and neuroinflammation. Previous studies have reported cocaine amphetamine regulated transcript (CART) treatment improves memory synaptic structure...
Summary Aims Accumulated evidence indicates that cerebral metabolic features, evaluated by proton magnetic resonance spectroscopy ( 1 H‐ MRS ), are sensitive to early mitochondrion dysfunction associated with mitochondrial encephalomyopathy ME ). The metabolite ratios of lactate (lac)/Cr, N‐acetyl aspartate NAA )/creatine (Cr), total choline tC ho)/Cr, and myoinositol mI )/Cr measured in the infarct‐like lesions may reveal changes . However, application this molecular imaging technique...
Summary Aims The purpose of this study was to evaluate the energy metabolism and mitochondrial function in skeletal muscle from patients with Mitochondrial encephalomyopathy, lactic acidosis, stroke‐like episodes ( MELAS ) or chronic progressive external ophthalmoplegia CPEO using phosphorus magnetic resonance spectroscopy 31 P‐ MRS ), determine whether abnormally increasing cytochrome c oxidase COX as detected biopsy, could be a cause for . Methods performed on quadriceps femoris 12 healthy...
Due to the complicated clinical features of mitochondrial encephalomyopathy, simplified disease criteria (MDC) have recently been established in Europe. This study evaluated sensitivity and specificity this scoring system Chinese patients. Seventy-eight patients with suspected encephalomyopathy were recruited be scored by MDC further classified into "possible" (2-4), "probable" (5-7), or "definite" categories (≥8). Significant differences observed between total scores group other myopathy...
To summarize the clinical, imaging, and pathological characteristics of mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes syndrome (MELAS) to improve diagnosis this rare disease.
Pompe disease is a rare, progressive, and life-threatening autosomal recessive disorder. In its late-onset form, the primarily characterised by mild progressive proximal limb respiratory muscle weakness. Mutations in acid alpha-glucosidase (GAA) gene cause lysosomal enzyme GAA to be significantly reduced or missing altogether, for which supplementation can given through replacement therapy.Fourteen patients diagnosed with (LOPD) First Affiliated Hospital of Nanjing Medical University from...
To develop and validate 3 radiomics nomograms for preoperative prediction of pathological progression diagnosis in non-small cell lung cancer (NSCLC) as well circulating tumor cells (CTCs). A total 224 134 patients diagnosed with NSCLC were respectively gathered 2018 2019 this study. There totally 1197 features that extracted quantified from the images produced by computed tomography. Then we selected predictive value least absolute shrinkage selection operator combined them into signature....
The aim of this study was to investigate the biological role and molecular mechanism p22 phox in epithelial ovarian cancer.Immunohistochemistry employed determine expression level cancer tissues.The effects on cell proliferation, tumorigenesis, chemosensitivity were evaluated by CCK-8, EdU assay, colony formation apoptosis assays vitro mouse experiments vivo.Immunoprecipitation analyses utilized explore potential mechanisms mediated downstream signaling, RT-PCR western blot used confirm...
Objective To improve the recognition for infantile spinal muscular atrophy (SMA-I) and level of early diagnosis, intervention treatment SMA-I. Methods The clinical data 39 patients with SMA-I were analyzed retrospectively, including manifestations, neural electrophysiological characteristics, genotype, prognosis SMA-I. Results Of cases , 37 cases(94.9%) had onset in 6 months after birth.The paralyses limbs symmetrical flaccid.The lower was more severe than upper proximal distal,...
目的： 探讨ZFTA-NCOA1/2融合伴间叶分化的室管膜瘤样肿瘤（ependymoma-like tumors with mesenchymal differentiation，ELTMD）的临床病理和分子学特征。 方法： 通过免疫组织化学、RNA测序以及荧光原位杂交验证，证实1例ZFTA-NCOA1/2融合的幕上室管膜瘤样肿瘤，总结其临床病理特征。 结果： 患儿女，4岁，突发头痛头晕伴肢体无力，右额顶部镰旁富血供占位性病变。HE组织学具有显著的异质性和混合性成分，由小蓝圆细胞和梭形细胞成分构成，类似高级别肉瘤和胚胎性肿瘤，偶见室管膜样分化。免疫表型L1CAM弥漫阳性，p65核阴性。RNA测序示ZFTA-NCOA1/2基因融合。 结论： ELTMD是一类罕见的儿童高级别肿瘤，WHO暂未归类，具有显著的异源性间叶分化，免疫表型和分子特征不同于幕上室管膜瘤或中枢神经系统胚胎型肿瘤，组织学相当于WHO 3级。.