A5015208615- Healthcare and Venom Research
- Nonmelanoma Skin Cancer Studies
- Cancer-related Molecular Pathways
- Heat shock proteins research
- Fermentation and Sensory Analysis
- Bladder and Urothelial Cancer Treatments
- Cardiac Ischemia and Reperfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Cutaneous lymphoproliferative disorders research
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- Cancer and Skin Lesions
- Fungal Biology and Applications
- Seaweed-derived Bioactive Compounds
- Cell Adhesion Molecules Research
- Polysaccharides and Plant Cell Walls
- Psoriasis: Treatment and Pathogenesis
- Microbial Metabolic Engineering and Bioproduction
- Mast cells and histamine
- Cancer Research and Treatments
- Cytomegalovirus and herpesvirus research
- Molecular Biology Techniques and Applications
- FOXO transcription factor regulation
- vaccines and immunoinformatics approaches
First Affiliated Hospital of Xi'an Jiaotong University
2022-2025
Wuhu Fourth People Hospital
2024
Xian Yang Central Hospital
2024
Fujian Academy of Agricultural Sciences
2022-2023
Aarhus University Hospital
2023
Shaanxi Provincial People's Hospital
2022
Chengdu University of Traditional Chinese Medicine
2009-2021
Nanjing University of Chinese Medicine
2021
Southern Medical University Shenzhen Hospital
2017-2020
Xiamen Chang Gung Hospital
2020
Psoriasis is one of several chronic inflammatory skin diseases with a high rate recurrence, and its pathogenesis remains unclear. Nicotinamide mononucleotide (NMN), as an important precursor nicotinamide adenine dinucleotide (NAD+), has been reported to be promising agent in treating various diseases, positive effects including those induced via anti-inflammatory antioxidant properties. For this reason, we have aimed explore the possible role NMN treatment psoriasis. models were constructed...
Brodalumab, a humanized monoclonal antibody that targets the interleukin-17 receptor A, is primarily used to manage moderate-to-severe plaque psoriasis. Although it has demonstrated favorable efficacy and safety in clinical trials, strict inclusion exclusion criteria may not fully reflect its profile real-world settings. As use becomes more widespread practice, understanding applications crucial.This study employed disproportionality analysis assess of brodalumab by examining all adverse...
Mitochondrial malfunction is traditionally viewed as a major factor in tumor growth and malignancy, while recent studies have introduced conflicting views suggesting the necessity of functional mitochondria for growth. Despite these differing perspectives, specific role cutaneous squamous cell carcinoma (cSCC) remains poorly understood. In this study, we observed increased mitochondrial abundance function during development cSCC. We also identified retinoic acid receptor response 1...
ABSTRACT Background Hair loss disorders, including non‐cicatricial forms such as alopecia areata (AA) and androgenetic (AGA), well cicatricial forms, represent significant dermatological concerns influenced by various factors, lipid metabolism. While observational studies clinical trials have suggested a link between levels hair loss, the causal relationship remains unclear. Methods We conducted comprehensive analysis of 983 variables [including triglycerides (TG), fatty acids, cholesterol,...
Several studies have reported the association between pure hypercholesterolemia (PH) and psoriasis, but causal effect remains unclear.We explored PH psoriasis using two-sample bidirectional Mendelian randomization (MR) analysis data from genome-wide studies. Single nucleotide polymorphisms related with exposures at significance level (p < 5×10-8 ) less than linkage disequilibrium (r2 0.001) were chosen as instrumental variables. Subsequently, we used inverse variance weighting (IVW),...
Hongqu Huangjiu is considered to have higher fusel oil content than other alcoholic beverages. Saccharomyces cerevisiae the microorganism most responsible for production during fermentation. We found that ADH7 gene loss might be closely related low of S. cerevisiae. The aim this study was determine effect on metabolism strain JH301 used as research with production, model S288c control strain. complementation in strains JH301-A1, JH301-A2, and JH301-A3 carried out by rDNA-mediated multicopy...
Acne is the eighth most frequent disease worldwide. Inflammatory response runs through all stages of acne. It complicated and involved in innate adaptive immunity. This study aimed to explore candidate genes their relative signaling pathways inflammatory acne using data mining analysis. Microarray GSE6475 GSE53795, including 18 lesion tissues matched normal skin tissues, were obtained. Differentially expressed (DEGs) filtered subjected functional pathway enrichment analyses. Protein-protein...
Many patients with asthma experience alopecia areata (AA) in their lives. However, it is unclear whether causes or results from AA. Our objective was to investigate the genetic causal relationship between and
Alzheimer's disease (AD) is the most common form of dementia that primarily characterized by progressive cognitive deficits. The toxicity amyloid β‑protein (Aβ) serves an important role in progression AD, resulting neuronal loss via a number possible mechanisms, including oxidative stress, mitochondrial dysfunction, energy depletion, apoptosis and neuroinflammation. Previous studies have reported cocaine amphetamine regulated transcript (CART) treatment improves memory synaptic structure...
Withaferin A, a withanolide obtained from Withania somnifera exhibits remarkable pharmacological properties. A has been reported to exert cytotoxic effects against human multiple myeloma cells. Nevertheless, the in-depth understanding of withaferin induced antiproliferative cells is still unclear. The results showed that inhibited viability six different with lowest IC50 9 μM U266B1 and IM-9 cell lines. colony formation in dose time-dependent manner. DAPI annexin V/PI staining assays...
Objective: Kidney is sensitive to ischemia–reperfusion (I/R) injury because of its special structure and function. In this study, we aimed explore the mechanism desflurane (DFE) preconditioning effecting on renal I/R in rats. Methods: Renal rats model was constructed, expressions serum function parameters (blood urea nitrogen (BUN) creatinine (SCr)) lipid peroxidation-related factors were detected using corresponding commercial kits assess degrees functional damage oxidative stress....
Objective To assess the trends in non-melanoma skin cancer (NMSC) incidence Hong Kong from 1990 to 2019 and associations of age, calendar period, birth cohort, make projections 2030, examine drivers NMSC incidence.Methods We assessed cohort effects between using an age-period-cohort model. Using Bayesian analysis with integrated nested Laplace approximations, we projected 2030.Results From 2019, age-standardized rate increased 6.7 per 100,000 population 8.6 men 5.4 5.9 women, among 19,568...
There is a potential safety risk with ethyl carbamate (EC) in Hongqu Huangjiu production; 90% of the EC rice wine produced by reaction urea alcohol Saccharomyces cerevisiae . In our previous experiments, we screened and obtained S. strain JH301 that offered low production. However, key genes responsible for production remain unclear. Here, whole genome sequencing was accomplished via next-generation high-throughput long-read technology. are six main pathways related to metabolism based on...
Abstract Mycosis Fungoides (MF) is the most common subtype of cutaneous T‐cell lymphomas (CTCL). Shank‐associated RH domain‐interacting protein (SHARPIN) participates in initiation and development multiple tumors. However, clinical significance SHARPIN MF hasn't been investigated. The c‐Jun N‐terminal kinases (JNKs) pathway a member mitogen‐activated (MAPKs). Its dysregulation observed various tumors including CTCL, whereas roles JNKs remain largely unknown, relationship between remains...