A5025598800- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- Oral microbiology and periodontitis research
- Rheumatoid Arthritis Research and Therapies
- Cancer, Lipids, and Metabolism
- Skin Protection and Aging
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Computational Drug Discovery Methods
- Wnt/β-catenin signaling in development and cancer
- Food Allergy and Anaphylaxis Research
- Melanoma and MAPK Pathways
- HIV-related health complications and treatments
- Cancer-related Molecular Pathways
- Bee Products Chemical Analysis
- Asthma and respiratory diseases
- HIV/AIDS Research and Interventions
- Contact Dermatitis and Allergies
- FOXO transcription factor regulation
- Vitamin D Research Studies
- melanin and skin pigmentation
- Hippo pathway signaling and YAP/TAZ
- Biotin and Related Studies
First Affiliated Hospital of Xi'an Jiaotong University
2023-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2022
Melanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, overall survival patients melanoma remains unsatisfactory. Thus, a further understanding pathogenesis may aid towards development strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) key enzyme that converts lysophosphatidylcholine into phosphatidylcholine lipid remodeling. In present study, LPCAT1...
Abstract Background Psoriasis is a common autoimmune inflammatory disease. Vitamin B6 crucial for the body’s response, yet relationship between pyridoxal 5'-phosphate (PLP), 4-pyridoxic acid (4-PA), and vitamin turnover (4-PA/PLP) in psoriasis remains unexplored. Objective To investigate of PLP, 4-PA catabolism with risk psoriasis. Methods This cross-sectional study analyzed 7,540 participants from National Health Nutrition Examination Survey. was assessed via serum to PLP ratio (4-PA/PLP)....
ABSTRACT Background Hair loss disorders, including non‐cicatricial forms such as alopecia areata (AA) and androgenetic (AGA), well cicatricial forms, represent significant dermatological concerns influenced by various factors, lipid metabolism. While observational studies clinical trials have suggested a link between levels hair loss, the causal relationship remains unclear. Methods We conducted comprehensive analysis of 983 variables [including triglycerides (TG), fatty acids, cholesterol,...
An increasing amount of evidence suggests that psoriasis and nonalcoholic steatohepatitis (NASH) may occur simultaneously, whereas the underlying mechanisms remain unclear. Our research aims to explore potential comorbidity mechanism in steatohepatitis.
Several studies have reported the association between pure hypercholesterolemia (PH) and psoriasis, but causal effect remains unclear.We explored PH psoriasis using two-sample bidirectional Mendelian randomization (MR) analysis data from genome-wide studies. Single nucleotide polymorphisms related with exposures at significance level (p < 5×10-8 ) less than linkage disequilibrium (r2 0.001) were chosen as instrumental variables. Subsequently, we used inverse variance weighting (IVW),...
Abstract Background Lichen planus is a chronic inflammatory disorder. Transcriptional coactivator with PDZ‐binding motif (TAZ/WWTR1) an important downstream effector of the Hippo pathway which regulates organ size and tissue homeostasis. But little known about role TAZ in lichen so far. Objective To explore expression normal skin, to discover relationship between clinical characteristics patients. Methods The method immunohistochemistry was performed quantify 262 patients 90 control tissues....
Background: Psoriasis is a chronic, inflammatory and recurrent skin disease. Xiao-Chai-Hu Decoction (XCHD) has shown good effects against some diseases cancers. However, the pharmacological effect mechanisms of XCHD on psoriasis are not yet clear. Objective: To uncover by integrating network pharmacology, molecular docking, in vivo experiments. Methods: The active ingredients corresponding targets were screened through Traditional Chinese Medicine Systems Pharmacology Database Analysis...
Skin cutaneous melanoma (SKCM) is a highly malignant form of skin cancer, known for its unfavorable prognosis and elevated mortality rate. RARRES1, gene responsive to retinoic acid receptors, displays varied functions in various cancer types. However, the specific role underlying mechanisms RARRES1 SKCM are still unclear. GSE15605 was utilized analyze expression SKCM. Subsequently, TCGA GEO databases were employed investigate relationships between clinicopathological parameters, as well...
Abstract Background Reports suggest that lipid profiles may be linked to the likelihood of developing skin cancer, yet exact causal relationship is still unknown. Objective This study aimed examine connection between lipidome and cancers, as well investigate any possible mediators. Methods A two‐sample Mendelian randomization (MR) analysis was conducted on 179 lipidomes each cancer based a genome‐wide association (GWAS), including melanoma, basal cell carcinoma (BCC), squamous (SCC). Then,...
Abstract Background Increasing evidence indicates that psoriasis (PSO) and periodontitis (PD) are likely to occur together, however, the underlying mechanism remains unclear. Materials methods The expression profiles of PSO (lesion vs non-lesion, GSE30999, GSE14905) PD (affected unaffected gingival tissue, GSE16134, GSE10334) were downloaded from GEO database. First, we investigated common differentially expressed genes (DEGs) PD. Then, GO KEGG enrichment analysis, protein interaction...
Psoriasis is a chronic inflammatory skin disease, and elevation of proinflammatory cytokine levels critical driver the pathogenesis psoriasis. Extracellular cold-inducible RNA-binding protein (eCIRP) has been shown to play role in various acute diseases. C23, short peptide derived from CIRP, competitively binds CIRP receptors reduces damage However, effect eCIRP psoriasis not studied. In present study, we investigated expression cytokines keratinocytes. Our data show that was increased sera...
Abstract Background Our study aimed to the involvement of ubiquitin‐conjugating enzyme E2C (UBE2C) in cutaneous squamous cell carcinoma (cSCC). As second most common malignancy with a rising incidence, understanding molecular mechanisms driving cSCC is crucial for improved diagnosis and treatment. Methods We combined multiple datasets Gene Expression Omnibus (GEO) repository investigate its expression diagnostic value. collected patient specimens performed immunohistochemistry examine...
ATP citrate lyase, the first rate-limiting enzyme in de novo lipogenesis, plays a crucial role tumour progression. This study explores lyase's potential as biomarker and its cutaneous squamous cell carcinoma. lyase expression patterns were analysed using TCGA TIMER databases, patient skin specimens collected for immunohistochemistry to determine levels. Cell proliferation, cycle, apoptosis, c-Myc assessed A431 SCL-1 cells. Stable lines with reduced obtained subcutaneously implanted into nude...
Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin malignancies, and its incidence rate increasing worldwide. Proline-rich 11 (PRR11) has been reported to be involved in occurrence development various tumors. However, role PRR11 cSCC remains unknown. In present study, we observed upregulated expression tissues lines. Knockdown lines A431 SCL-1 inhibited proliferation by inducing cycle arrest during G1/S phase transition, promoted apoptosis, reduced migration invasion...
To explore differentially expressed genes (DEGs) associated with autophagy in psoriasis using bioinformatics analysis and verify them an M5-induced psoriatic cell model.
This study explored disparities in characteristics and mortalities among four major transmission groups on antiretroviral therapy northwest China as well the survival impact of each route.We first examined demographics clinical populations. Kaplan Meier analysis was subsequently conducted to compare rates all groups. At last, Cox proportional hazards regression model employed analyze a route seven main categories factors associated with all-cause mortalities.Survival showed significant...