A5100365278- Obsessive-Compulsive Spectrum Disorders
- Sleep and Wakefulness Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Regulation of Appetite and Obesity
- Autism Spectrum Disorder Research
- Mast cells and histamine
- Olfactory and Sensory Function Studies
- Neurological disorders and treatments
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Sleep and related disorders
- Body Image and Dysmorphia Studies
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Eating Disorders and Behaviors
- Sexuality, Behavior, and Technology
- Language, Metaphor, and Cognition
- Neural and Behavioral Psychology Studies
- Acupuncture Treatment Research Studies
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Logic, programming, and type systems
Capital Medical University
2019-2025
Beijing Hospital of Traditional Chinese Medicine
2019-2025
Sichuan University
2013-2024
West China Hospital of Sichuan University
2013-2024
Nanjing Medical University
2021-2024
Jiangsu Province Hospital
2021-2024
City University of Hong Kong
2023
Shandong Mental Health Center
2023
Shenyang Agricultural University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2020
Significance Anxiety disorders and obsessive-compulsive disorder (OCD) are highly prevalent debilitating psychiatric commonly co-occurring in our stressful modern life. Yet the common effective therapeutic target is still unknown. Here we report that activation of histaminergic afferent system, particularly histamine H3 receptor, nucleus accumbens (NAc) core, a vital node limbic loop, inhibits glutamatergic synaptic transmission circuit from prelimbic prefrontal cortex (PrL) to NAc improves...
Abstract Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies of obsessive-compulsive disorder (OCD) have facilitated our understanding OCD pathophysiology based on its intrinsic activity. However, whether the group difference derived from univariate analysis could be useful for informing diagnosis individual patients remains unclear. We aimed to apply multivariate pattern different rs-fMRI parameters distinguish drug-naive with healthy control subjects (HCS)....
To use diffusion-tensor (DT) magnetic resonance (MR) imaging to explore the integrity and connectivity of brain white matter in patients with obsessive-compulsive disorder (OCD) correlate DT parameters clinical measures.This study was approved by local ethical committee, written informed consent obtained from all participants. performed using a 3.0-T MR imager 23 OCD healthy control subjects matched for age, sex, education level, handedness. By voxel-based analysis, fractional anisotropy...
The subthalamic nucleus (STN) is an effective therapeutic target for deep brain stimulation (DBS) Parkinson's disease (PD), and histamine levels are elevated in the basal ganglia PD patients. However, effect of endogenous histaminergic modulation on STN neuronal activities mechanism underlying STN-DBS unknown. Here, we report that firing patterns more crucial than rates motor control. Histamine excited neurons, but paradoxically ameliorated parkinsonian deficits, which attributed to...
Background and Purpose— We aimed to develop a risk score (intracerebral hemorrhage–associated pneumonia score, ICH-APS) for predicting hospital-acquired stroke-associated (SAP) after ICH. Methods— The ICH-APS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) validation (40%) cohorts. Variables routinely collected at presentation used SAP For testing added value of hematoma volume measure, we separately 2...
Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies have revealed intrinsic regional activity alterations in obsessive-compulsive disorder (OCD), but those results were based on group analyses, which limits their applicability to clinical diagnosis and treatment at the level of individual. We examined fractional amplitude low-frequency fluctuation (fALFF) applied support vector machine (SVM) discriminate OCD patients from healthy controls basis rs-fMRI data. Values...
Insomnia causes severe health problems and poor quality of life in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (MHD). Conventional therapies are limited due to the availability opaque evidence, electroacupuncture (EA) is considered an alternative for improving insomnia ESRD MHD. This a study protocol pilot randomized, sham-controlled, single-center, clinical trial. A total 60 MHD will be randomly assigned treatment group (EA, 3 sessions per week 4 weeks),...
Recent advances in functional magnetic resonance imaging (fMRI) have facilitated the pathophysiology model of obsessive-compulsive disorder (OCD) that encompass a specific network cortico-striato-thalamo-cortical regions. However, alterations localized connectivity OCD remains to be fully characterized. In current study, we aimed apply both univariate analysis and multivariate pattern (MVPA) approach evaluate abnormalities relatively large sample medication-free patients with OCD. A total 88...
The dorsolateral prefrontal cortex (DLPFC), a key structure in the executive system, has consistently emerged as crucial element pathophysiology of obsessive–compulsive disorder (OCD). However, neural primacy DLPFC remains elusive this disorder. We investigated causal interaction (measured by effective connectivity) between and remaining brain areas using bivariate Granger causality analysis resting-state fMRI collected from 88 medication-free OCD patients matched healthy controls....
Anxiety disorders are one of the most common mental disorders. Ghrelin is a critical orexigenic brain-gut peptide that regulates food intake and metabolism. Recently, ghrelin system has attracted more attention for its crucial roles in psychiatric disorders, including depression anxiety. However, underlying neural mechanisms involved have not been fully investigated.
OBJECTIVE Anterior capsulotomy (AC) is sometimes used as a last resort for treatment-refractory obsessive-compulsive disorder (OCD). Previous studies assessing neuropsychological outcomes in patients with OCD have identified several forms of cognitive dysfunction that are associated the disease, but few focused on changes function who undergone surgery. In present study, authors investigated effects AC OCD. METHODS The selected 14 had bilateral between 2007 and 2013, nonsurgically treated...
To examine the psychometric properties of Chinese version Yale-Brown Obsessive Compulsive Scale - Second Edition (Y-BOCS-II).A total 86 adults with a primary diagnosis obsessive-compulsive disorder (OCD), ranging in age from 15 to 78 years, participated study. Participants were administered Y-BOCS-II by trained clinician who also rated overall illness severity on two additional measures. Patients completed Inventory-Revised and Depression Anxiety Stress Scale-21.Results indicated high...