A5100440662- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Treatment of Major Depression
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV Research and Treatment
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Transcranial Magnetic Stimulation Studies
- Attention Deficit Hyperactivity Disorder
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Neuroscience and Music Perception
- Hearing Loss and Rehabilitation
- Heart Rate Variability and Autonomic Control
- Alzheimer's disease research and treatments
- Sleep and related disorders
- Sleep and Wakefulness Research
Sichuan University
2018-2025
West China Hospital of Sichuan University
2018-2025
First People's Hospital of Yunnan Province
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
State Key Laboratory of Medicinal Chemical Biology
2024
Fuyang Second People's Hospital
2024
Nankai University
2024
University of South Carolina
2022-2023
West China Medical Center of Sichuan University
2021-2022
Zhejiang Hospital
2019-2020
The whole-brain functional connectivity (FC) pattern obtained from resting-state magnetic resonance imaging data are commonly applied to study neuropsychiatric conditions such as autism spectrum disorder (ASD) by using different machine learning models. Recent studies indicate that both hyper- and hypo- aberrant ASD-associated FCs were widely distributed throughout the entire brain rather than only in some specific regions. Deep neural networks (DNN) with multiple hidden layers have shown...
Abstract Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies of obsessive-compulsive disorder (OCD) have facilitated our understanding OCD pathophysiology based on its intrinsic activity. However, whether the group difference derived from univariate analysis could be useful for informing diagnosis individual patients remains unclear. We aimed to apply multivariate pattern different rs-fMRI parameters distinguish drug-naive with healthy control subjects (HCS)....
Background Major depressive disorder (MDD) is a clinically and biologically heterogeneous syndrome. Identifying discrete subtypes of illness with distinguishing neurobiological substrates clinical features promising strategy for guiding personalised therapeutics. Aims This study aimed to identify depression correlated patterns functional network connectivity symptoms by clustering patients according weighted linear combination both in relatively large, medication-naïve sample. Method We...
Abstract Obsessive–compulsive disorder (OCD) displays alterations in regional brain activity represented by the amplitude of low‐frequency fluctuation (ALFF), but time‐varying characteristics this local neural remain to be clarified. We aimed investigate dynamic changes intrinsic a relatively large sample drug‐naïve OCD patients using univariate and multivariate analyses. applied sliding‐window approach calculate ALFF (dALFF) compared difference between 73 age‐ sex‐matched healthy controls...
Objective Amygdala-based network dysfunction has been found to be centrally implicated in major depressive disorder (MDD). However, relatively little is known about how different forms of effective or cognitive are modulated MDD. Therefore, the current study, we aimed examine alteration amygdala subregional networks adult patients with MDD explore whether parts that functionally connected regions contribute differently cerebral mechanism depression. Methods Resting-state fMRI scans were...
The hippocampus and amygdala are important structures in the posttraumatic stress disorder (PTSD); however, exact relationship between these or PTSD remains unclear. Moreover, they consist of several functionally distinct subfields/subregions that may serve different roles neuropathophysiology PTSD. Here we present a subregional profile 145 survivors major earthquake 56 non-traumatized healthy controls (HCs). We found bilateral left were significantly smaller than HCs, there was no...
We previously demonstrated that Pre-B-cell colony-enhancing factor (PBEF), also known as nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in mammalian NAD(+) biosynthesis pathway, plays a brain and neuronal protective role ischemic stroke. In this study, we further investigated mechanism of its neuroprotective effect after ischemia primary cultured mouse cortical neurons. Using apoptotic cell death assay, fluorescent imaging, molecular biology, mitochondrial...
Recent advances in functional magnetic resonance imaging (fMRI) have facilitated the pathophysiology model of obsessive-compulsive disorder (OCD) that encompass a specific network cortico-striato-thalamo-cortical regions. However, alterations localized connectivity OCD remains to be fully characterized. In current study, we aimed apply both univariate analysis and multivariate pattern (MVPA) approach evaluate abnormalities relatively large sample medication-free patients with OCD. A total 88...
The dorsolateral prefrontal cortex (DLPFC), a key structure in the executive system, has consistently emerged as crucial element pathophysiology of obsessive–compulsive disorder (OCD). However, neural primacy DLPFC remains elusive this disorder. We investigated causal interaction (measured by effective connectivity) between and remaining brain areas using bivariate Granger causality analysis resting-state fMRI collected from 88 medication-free OCD patients matched healthy controls....
Abstract Brain networks exhibit signatures of modular structure, which maintains a fine trade‐off between wiring cost and efficiency information transmission. Alterations in structure have been found patients with obsessive–compulsive disorder (OCD). However, previous studies were focused on single scale (i.e., modularity or intra/intermodular connectivity) for investigation. Here, we recruited 92 OCD 90 healthy controls. A comprehensive analysis was performed architecture alterations the...