A5055886928- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Bacteriophages and microbial interactions
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Immunotherapy and Immune Responses
- Advanced oxidation water treatment
- Polymer Science and PVC
- Biopolymer Synthesis and Applications
- Advanced Drug Delivery Systems
- Ferroptosis and cancer prognosis
- Surfactants and Colloidal Systems
- Viral Infections and Outbreaks Research
- Pharmaceutical studies and practices
- Ultrasound and Cavitation Phenomena
- Acute Ischemic Stroke Management
- Photodynamic Therapy Research Studies
- Medicinal Plants and Bioactive Compounds
- Arsenic contamination and mitigation
- Bacterial biofilms and quorum sensing
- Nuclear materials and radiation effects
- Effects and risks of endocrine disrupting chemicals
Beijing National Laboratory for Molecular Sciences
2015-2024
Chinese Academy of Sciences
2015-2024
Shanghai Jiao Tong University
2021-2024
Shanghai Cancer Institute
2021-2024
Renji Hospital
2021-2024
Nanjing Forestry University
2024
CAS Key Laboratory of Urban Pollutant Conversion
2021-2023
University of Science and Technology Beijing
2021-2023
State Key Laboratory of Oncogene and Related Genes
2021-2022
University of Chinese Academy of Sciences
2017-2022
Synergistic phototherapy stands for superior treatment prospects than a single phototherapeutic modality. However, the combined photosensitizers often suffer from incompatible excitation mode, limited irradiation penetration depth, and lack of specificity. We describe development upconversion dual-photosensitizer-expressing bacteria (UDPB) near-infrared monochromatically excitable combination phototherapy. UDPB are prepared by integrating genetic engineering surface modification, in which...
Abstract Methods capable of manipulating bacterial colonization are great significance for modulating host-microbiota relationships. Here, we describe a strategy in-situ chemical reaction-mediated covalent localization bacteria. Through simple one-step imidoester reaction, primary amino groups on surface can be converted to free thiols under cytocompatible conditions. Surface thiolation is applicable modify diverse strains and the number introduced per bacterium easily tuned by varying feed...
Approaches capable of simultaneously treating cancer and protecting susceptible patients from lethal infections such as coronavirus disease 2019, are highly desirable but prove to be difficult. Here, dressing bacteria with a hybrid immunoactive nanosurface is reported elicit dual anticancer antiviral immunity. A combination checkpoint blocking antibody virus-specific antigen covalently conjugated polydopamine nanoparticles, which can anchored onto bacterial surface, by one-step in situ...
Bacteriophages (phages) are widely explored as antimicrobials for treating infectious diseases due to their specificity and potency infect inhibit host bacteria. However, the application of phages intracellular pathogens has been greatly restricted by inadequacy in cell entry endosomal escape. Here, we describe use cationic polymers selectively cap negatively charged phage head rather than positively tail electrostatic interaction, resulting charge-reversed with uninfluenced vitality. Given...
Background and Purpose— We aimed to develop a risk score (intracerebral hemorrhage–associated pneumonia score, ICH-APS) for predicting hospital-acquired stroke-associated (SAP) after ICH. Methods— The ICH-APS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) validation (40%) cohorts. Variables routinely collected at presentation used SAP For testing added value of hematoma volume measure, we separately 2...
Abstract G-quadruplex has attracted considerable attention due to their prevalent distribution in functional genomic regions and transcripts, which can importantly influence biological processes such as regulation of telomere maintenance, gene transcription translation. Artificial receptor study been developed for accurate identification from DNA species, since it is important the related basic research, clinical diagnosis, therapy. Herein, fluorescent dye ThT-E, a derivative known...
A fluorescent cationic benzothiazole dye that selectively targets a G-quadruplex aptamer was designed and synthesized as K<sup>+</sup> sensor.
Burkitt lymphoma (BL) is a rare and highly aggressive type of non-Hodgkin lymphoma. The mortality rate BL patients very high due to the rapid growth frequent systemic spread disease. A better understanding pathogenesis, more sensitive diagnostic tools effective treatment methods for are essential. Metabolomics, an important aspect systems biology, allows comprehensive analysis global, dynamic endogenous biological metabolites based on their nuclear magnetic resonance (NMR) mass spectrometry...
Indolizinone could selectively recognize c-myc promoter G-quadruplex.
Abstract Tumor malignancy highly depends on the stiffness of tumor matrix, which mainly consists collagen. Despite destruction matrix is conducive to therapy, it causes risk metastasis. Here, metal‐anesthetic network‐coated dormant collagenase‐producing Clostridium constructed simultaneously destruct and inhibit By metal‐phenolic complexation π – stacking interactions, a Fe 3+ ‐propofol network formed bacterial surface. Coated can selectively germinate rapidly proliferate in sites due...
Acute lymphoblastic leukemia (ALL) is one of the common malignant tumors. Compared with childhood ALL, treatment effect adult B-cell ALL less effective and remains a big challenge. In order to explore pathogenesis find new diagnostic biomarkers develop sensitive tools, we investigated plasma metabolites by using 1H NMR (nuclear magnetic resonance) metabolomics. Relative healthy controls, patients showed abnormal metabolism, including glycolysis, gluconeogenesis, amino acid fatty metabolism...
The eye is susceptible to viral infections, causing severe ocular symptoms or even respiratory diseases. Methods capable of protecting the from external invasion in a long-term and highly effective way are urgently needed but have been proved be extremely challenging. Here, strategy forming long-acting protective surface described by instilling adhesive dual-antiviral nanoparticles. Taking pseudotyped acute syndrome coronavirus 2 (SARS-CoV-2) as model virus, antiviral agent-loaded...
Abstract As one of the most common complications, infection causes majority mortality in cancer patients. However, therapeutic strategies that can simultaneously suppress tumors and protect patients from have been rarely reported. Here, use dual‐antigen‐displaying nanovaccines (DADNs) is described to elicit synergistic immunoactivation for treating preventing infectious complications. DADNs are prepared by wrapping immunoadjuvant‐loaded nanoparticles with a hybrid coating, which fused cell...