Abstract Chiral α-aryl glycines play a key role in the preparation of some bioactive products, however, their catalytic asymmetric synthesis is far from being satisfactory. Herein, we report an efficient nickel-catalyzed hydrogenation N -aryl imino esters, affording chiral high yields and enantioselectivities (up to 98% ee). The can be conducted on gram scale with substrate/catalyst ratio up 2000. obtained - p -methoxyphenyl glycine derivatives are not only directly useful secondary amino...

Abstract Sulfur‐fluoride exchange (SuFEx) reaction is an emerging class of click chemistry reaction. Owing to its efficient reactivity under physiological conditions, SuFEx used construct covalent protein drugs. Herein, a affibody‐molecular glue drug conjugate nanoagent reported, which can irreversibly bind with target through proximity‐enabled As proof concept, latent bioreactive unnatural amino acid fluorosulfate‐L‐tyrosine (FSY) first introduced at site 36 the affibody cysteine mutation...

Bacteriophages (phages) are widely explored as antimicrobials for treating infectious diseases due to their specificity and potency infect inhibit host bacteria. However, the application of phages intracellular pathogens has been greatly restricted by inadequacy in cell entry endosomal escape. Here, we describe use cationic polymers selectively cap negatively charged phage head rather than positively tail electrostatic interaction, resulting charge-reversed with uninfluenced vitality. Given...

Honeycomb-structured microporous films were self-assembled from a new type of multiarm copolymer, hyperbranched poly(3-ethyl-3-oxetanemethanol)-star-polystyrene (HBPO-star-PS). The precursor consisting an HBPO core and number PS arms was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. film prepared the evaporation chloroform solution in humid atmosphere (the so-called breath figure method). Compared to our former work, hexagonally packed pores not...

The targeted nanoagents have shown great potential clinically for cancer therapy. Traditional nanodrugs are usually prepared through surface postmodification. Herein, a nanodrug is self-assembled from the amphiphilic precursor of targeting peptide RGD conjugated with cytotoxin epothilone B (Epo B) linker containing thioketal (tk) group that sensitive to reactive oxygen species (ROS). obtained RGD–tk–Epo conjugate nanoparticles (RECNs) stable and uniform, which facilitates improving...

Conjugated microporous polymers (CMPs) represent an important type of functional materials. In this area, morphological engineering has remained a major challenge. Here, we report the synthesis porphyrin-based CMP tubes (CMP-1) through template-free protocol. A mechanism study reveals that are formed by scrolling and closing ribbon-like structures. The possess high specific surface area 495 m2/g, along with improved optical properties including broadened absorption in visible-light region,...

An iridium-catalyzed remote site-switchable hydroarylation of alkenes was reported, delivering the products functionalized at subterminal methylene and terminal methyl positions on an alkyl chain controlled by two different ligands, respectively, in good yields with to excellent site-selectivities. The catalytic system showed functional group tolerance a broad substrate scope, including unactivated activated alkenes. More importantly, regioconvergent transformations mixtures isomeric were...

Affibody molecules are small non-immunoglobulin affinity proteins, which can precisely target to some cancer cells with specific overexpressed molecular signatures. However, the relatively short in vivo half-life of them seriously limited their application drug targeted delivery for therapy. Here an amphiphilic affibody-drug conjugate is self-assembled into nanomicelles prolong circulation time As example concept, nanoagent was prepared through self-assembly ZHER2:342-Cys auristatin E...

Molybdenum carbide-containing nanomaterials have drawn considerable attention in the application of hydrogen production electrocatalysts light high abundance, low cost, and Pt-like electronic structure molybdenum carbide. In this article, we report synthesis one-dimensional (1D) Mo2C/carbon mesoporous nanotubes (Mo2C/C PNTs) through a dual-template self-assembly approach, which employs 1D MoO3 nanobelts as structure-directing template well one Mo2C precursors, along with block copolymer...

This study aimed to evaluate the application value of personalized patient protocol technology (P3T) modular cardiac injection technique combined with iterative reconstruction algorithm, sinogram-affirmed (SAFIRE) in coronary computed tomography angiography (CCTA). A retrospective analysis was performed on 40 patients who underwent CCTA at Central Hospital Affiliated Shandong First Medical University. Patients were divided into two groups: control group (n=20), which received traditional...

Affinity proteins are multiple types of well-explored small scaffold with excellent tumor targeting performance. However, due to their size, the balance between rapid blood clearance and efficient accumulation remains a challenge for clinical application. The covalent mode, endowing affinity an irreversible binding ability receptor then decoupling pharmacodynamic effect from pharmacokinetics, may provide promising solution applications proteins. Herein, we develop chemical modification...

Upon irradiation with nanosecond pulsed UV laser, surface periodic microstructure and photoorientation occurred simultaneously on the azobenzene functionalized liquid crystalline dendrimer films. The orientation of azo groups was perpendicular to polarization laser dependent fluence. in-plane presented parabola-shaped behavior increase fluences. out-of-plane reorientation closely related thermal effect induced in procedure irradiation, which led transformation phase state from smectic...

Herein, we report a new and facile method for fabricating TiO(2)@mesoporous carbon hybrid materials. Uniform polydopamine (PDA) layers were coated onto the surface of titanate nanotubes (TNTs) TiO(2) nanorods (TNDs) through spontaneous adhesion self-polymerization dopamine during dipping process. Core-shell mesoporous with or nanoparticles encapsulated inside (TiO(2)@MC) then obtained by transforming PDA into carbonaceous ones calcination in nitrogen at 800 °C. The thickness is tens...

Survivin is a novel attractive target for cancer therapy; however, it considered undruggable because lacks enzymatic activities. Herein, we describe our efforts toward the discovery of series 4,11-dioxo-4,11-dihydro-1H-anthra[2,3-d]imidazol-3-ium derivatives as survivin inhibitors by targeting ILF3/NF110. Intensive structural modifications led us to identify lead compound AQIM-I, which remarkably inhibited nonsmall cell lung cells A549 with an IC50 value 9 nM and solid tumor proliferation...

Epothilone B (Epo B), a promising antitumor compound effective against various types of cancer cells in vitro. However, its poor selectivity for tumor and inadequate therapeutic windows significantly limit potential clinical application. Affibody is class non-immunoglobulin affinity proteins with precise targeting capability to overexpressed molecular receptors on cells, has been intensively investigated due exceptional properties. In this study, we present targeted nanoagent self-assembled...

Recombinant elastin-like polypeptides (ELPs) have emerged as an attractive nanoplatform for drug delivery due to their tunable genetically encoded sequence, biocompatibility, and stimuli-responsive self-assembly behaviors. Here, we designed biosynthesized HER2 (human epidermal growth factor receptor 2)-targeted affibody-ELP fusion protein (Z-ELP), which was subsequently conjugated with monomethyl auristatin E (MMAE) build a protein-drug conjugate (Z-ELP-M). Due its thermal response, Z-ELP-M...

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTKinetic Separation of Polymers with Different Terminals through Inclusion Complexation CyclodextrinJie Xue, Zhifeng Jia, Xulin Jiang, Yanping Wang, Liang Chen, Li Zhou, Peng He, Xinyuan Zhu, and Deyue YanView Author Information School Chemistry Chemical Technology, State Key Laboratory Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, 200240, People's Republic China; Instrumental...