A5101407226- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Traditional Chinese Medicine Analysis
- Advanced MRI Techniques and Applications
- Herbal Medicine Research Studies
- Pharmacological Effects of Natural Compounds
- Traumatic Brain Injury and Neurovascular Disturbances
- Ginkgo biloba and Cashew Applications
- Ginseng Biological Effects and Applications
- Plant chemical constituents analysis
- Dementia and Cognitive Impairment Research
- Medicinal plant effects and applications
- Immune Response and Inflammation
- Anatomy and Medical Technology
- Natural product bioactivities and synthesis
- Advanced Glycation End Products research
- Lipid metabolism and disorders
- Sesquiterpenes and Asteraceae Studies
- Medical Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Phytochemistry and Bioactive Compounds
- Cerebrovascular and Carotid Artery Diseases
Clinical Trial Investigators
2024
Nanjing Drum Tower Hospital
2008-2020
Nanjing Medical University
2010
Nanjing University
2010
The purpose of this study is to investigate the possible mechanism and neuroprotective effect human urinary kallidinogenase (HUK) in cerebral ischemia. mouse middle artery occlusion (MCAO) model was used. Mice were treated with HUK (20 PNAU/g per day, intravenous) or saline as control, from beginning reperfusion 72 h. Neurological deficits, infarct size, BWC measured at 6, 24, 48, h after MCAO, respectively. Pathological changes brain observed by TUNEL assay. Inflammatory factors real-time...
Importance Ginkgo diterpene lactone meglumine (GDLM) has attracted much attention because of its potential neuroprotective properties in ischemic stroke. The efficacy GDLM patients with acute stroke (AIS) needs to be verified by well-designed randomized clinical trials. Objective To assess the and safety AIS. Design, Setting, Participants This multicenter, randomized, double-blind, placebo-controlled, parallel-group trial involved 3448 who had AIS, were aged 18 80 years, a clinically...
Stroke patients with diabetes suffer from higher mortality rate and worsened neurological outcome. However, the responses of immune system to cerebral ischemia in setting remain poorly understood. In this study, we investigated temporal profile leukocyte mobilization brain infiltration following distal middle artery occlusion (dMCAO) db/db mouse model type 2 its db/+ normoglycemic controls. We found a significant increase brain-infiltrating CD4+ T cell at day 3 after dMCAO, delayed dramatic...
Modified Xijiao Dihuang (XJDH) decoction has been shown to exert powerful neuroprotective properties in clinical ischemic stroke treatment. It consists of 4 Chinese herbs: Buffalo Horn, Paeonia suffruticosa Andrews, Rehmannia glutinosa (Gaertn.) DC, and lactiflora Pall. In the present study, effect specific mechanisms XJDH protecting PC12 cells from oxygen-glucose deprivation-induced injury were investigated. was found that OGD/R significantly decreased cell viability lactate dehydrogenase...
Importance Previous studies revealed limited effectiveness of neuroprotective agents in treating acute ischemic stroke (AIS). Tongxinluo, developed from traditional Chinese medicines, has been recognized as a novel agent with anti-inflammatory properties that stabilize vulnerable plaques animal models and patients myocardial infarction. Objective To assess the efficacy safety Tongxinluo Design, Setting, Participants This multicenter, open-label, double-blind, randomized clinical trial...
Lacunar infarctions (LI) have been associated with a cognitive decline and an increased risk of dementia. However, the specific pattern spontaneous brain activity in patients mild impairment (MCI) concomintant silent lacunar infarction, remains unclear. Our objective was to assess differences MCI LI versus those without using resting-state functional magnetic resonance imaging (rs-fMRI). We recruited consecutive from dementia clinic Nanjing, China, who met Petersen's criteria for amnestic...
Lacunar infarctions (LI) have been associated with a cognitive decline and an increased risk of dementia. However, the specific pattern spontaneous brain activity in patients mild impairment (MCI) concomintant silent lacunar infarction, remains unclear. Our objective was to assess differences MCI LI versus those without using resting-state functional magnetic resonance imaging (rs-fMRI). We recruited consecutive from dementia clinic Nanjing, China, who met Petersen's criteria for amnestic...
Introduction: Subcortical ischemic small vessel disease (SIVD) causing hypoxic-ischemic white matter lesions is one of the major subtypes Vascular dementia. White damage associated with short-term working memory deficits in which medial prefrontal cortex (mPFC) plays a central role. Recent studies have reported that active neurons may produce changes and enhance connectivity. However, little known about how impairs whether neuronal activity promotes restore SIVD. In present study, we used...