A5084207564- Appendicitis Diagnosis and Management
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Diverticular Disease and Complications
- Gallbladder and Bile Duct Disorders
- Metastasis and carcinoma case studies
- Minimally Invasive Surgical Techniques
- Esophageal Cancer Research and Treatment
- Biliary and Gastrointestinal Fistulas
- Pancreatic and Hepatic Oncology Research
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- Pancreatitis Pathology and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Hernia repair and management
- Fatty Acid Research and Health
- Abdominal Surgery and Complications
- Intestinal and Peritoneal Adhesions
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Tracheal and airway disorders
- Growth Hormone and Insulin-like Growth Factors
First Affiliated Hospital of Zhengzhou University
2017-2025
Harbin Medical University
2012-2024
Second Affiliated Hospital of Harbin Medical University
2012-2024
Zhengzhou University
2019-2023
University of California, Los Angeles
2001-2023
Guangdong Academy of Sciences
2022
Academy of Medical Sciences
2021
First Affiliated Hospital of Harbin Medical University
2017
Wannan Medical College
2015
Duke University Hospital
2011
Mitochondrial morphology is dynamically remodeled by fusion and fission in cells, dysregulation of this process closely implicated tumorigenesis. However, the mechanism which mitochondrial dynamics influence cancer cell survival considerably less clear, especially hepatocellular carcinoma (HCC). In study, we systematically investigated alteration its functional role regulation autophagy HCC survival. Furthermore, underlying molecular mechanisms therapeutic application were explored depth....
Insulin-like growth factor-binding protein-3 (IGFBP-3) regulates IGF bioactivity and also independently modulates cell survival. By using a yeast two-hybrid screen to identify IGFBP-3-interacting proteins, we cloned humanin (HN) as an IGFBP-3-binding partner. HN is 24-aa peptide that has been shown specifically inhibit neuronal death induced by familial Alzheimer's disease mutant genes amyloid-β (Aβ). The physical interaction of with IGFBP-3 was determined be high affinity specificity...
Mitochondria are highly dynamic and undergo constant fusion fission that essential for maintaining physiological functions of cells. Recently, we have reported increased mitochondrial promotes autophagy apoptosis resistance in hepatocellular carcinoma (HCC) cell through ROS-mediated coordinated regulation NF-κB p53 pathways. However, little is known about the roles dynamics HCC proliferation, another key feature cancer In this study, systematically investigated functional role proliferation....
Insulin-like growth factor-binding protein-3 (IGFBP-3) induces apoptosis by its ability to bind insulin-like factors (IGFs) as well IGF-independent effects involving binding other molecules including the retinoid X receptor-alpha (RXRalpha). Here we describe that in response IGFBP-3, RXRalpha partner nuclear receptor Nur77 rapidly undergoes translocation from nucleus mitochondria, initiating an apoptotic cascade resulting caspase activation within 6 h. This is a type 1 IGF receptor-signaling...
Insulin-like growth factor binding protein-3 (IGFBP-3) is well established as a growth-inhibitory, apoptosis-inducing secreted molecule that acts via insulin-like (IGF)-independent IGF-dependent pathways. Nuclear localization of IGFBP-3 has been observed and nuclear partners for demonstrated. However, little known about the mechanism internalization. We hypothesized first then taken up again into cells its internalization could occur to transferrin or caveolin. Incubation with an...
The Wnt/β-catenin signaling pathway plays a key role during hepatocellular carcinoma (HCC) genesis and development. present study aimed to investigate the effects of on expression angiogenic growth factors involved in HCC. HCC HepG2 cell line was transfected with small interfering RNA (siRNA) against β-catenin. After 72 96 h, protein extracted levels β-catenin, matrix metalloproteinase (MMP)-2, MMP-9, vascular endothelial factor (VEGF)-A, VEGF-C basic fibroblast (bFGF) were detected by...
Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) possesses both growth-inhibitory and -potentiating effects on cells that are independent of IGF action mediated through specific IGFBP-3 binding proteins/receptors located at the cell membrane, cytosol, or nuclear compartments in extracellular matrix. We have here characterized transferrin (Tf) as one these proteins. Human serum was fractionated over an affinity column, a 70-kDa protein eluted, sequenced, identified (through...
Abstract Purpose: The current research was undertaken to examine the association between genetic variations in DNA repair and pancreatic cancer risk. Experimental Design: We analyzed 9 single nucleotide polymorphisms of 7 genes (LIG3, LIG4, OGG1, ATM, POLB, RAD54L, RECQL) 734 patients with adenocarcinoma 780 healthy controls using Taqman method. Information on cigarette smoking, alcohol consumption, medical history, other risk factors collected by personal interview. Results: homozygous...
Preclinical studies suggest lowering dietary fat and decreasing the ratio of omega-6 to omega-3 polyunsaturated fatty acids decreases risk prostate cancer development progression. We conducted a phase II randomized trial test effect combined with omega-6:omega-3 on biomarkers related Patients undergoing radical prostatectomy were randomly assigned receive low-fat diet 5 grams fish oil daily (dietary 2:1) or control Western (omega-6:omega-3 15:1) for four six weeks prior surgery. The primary...
BACKGROUND Ulcerative colitis is a chronic, idiopathic inflammatory disease that destroys the colon structure. Nevertheless, exact pathogenesis not clear and needs to be fully elucidated. MATERIAL AND METHODS Stool plasma samples were used for 16S ribosomal RNA sequencing liquid chromatography mass spectrometry, respectively. In addition, we detected level of trimethylamine N-oxide. Finally, performed Pearson correlation analysis between microbiome metabolome. RESULTS Twenty-three active...
Abstract Background This study aimed to investigate the diagnostic and therapeutic value of a digital single-operator cholangioscope (SOC) system for endoscopic management acute appendicitis. Methods 14 patients with uncomplicated simple or supportive appendicitis were evaluated between November 2018 September 2020. The diagnosis was confirmed by direct colonoscopy imaging cholangioscope. success rate SOC-assisted retrograde therapy (ERAT), procedure time, postoperative length hospital stay,...
Importance Ginkgo diterpene lactone meglumine (GDLM) has attracted much attention because of its potential neuroprotective properties in ischemic stroke. The efficacy GDLM patients with acute stroke (AIS) needs to be verified by well-designed randomized clinical trials. Objective To assess the and safety AIS. Design, Setting, Participants This multicenter, randomized, double-blind, placebo-controlled, parallel-group trial involved 3448 who had AIS, were aged 18 80 years, a clinically...
Objectives: Endoscopic retrograde appendicitis therapy (ERAT) is a new and non-invasive endoscopic technique originally developed by Liu in China for the management of acute appendicitis. While its safety efficacy have been extensively validated adult populations, evidence regarding use pediatric patients remains scarce. The aim this study was to evaluate clinical outcomes ERAT Methods: This retrospective analyzed who underwent our hospital between January 2019 August 2022. Data collected...
Patients with ulcerative colitis (UC) have a high risk of developing colorectal cancer. The aim the present study was to evaluate expression pattern Toll-like receptors (TLRs) in colonic mucosa patients UC. Colonic mucosal biopsy specimens were collected during colonoscopy from 30 UC and normal findings as controls. protein mRNA levels TLRs 1-4 TLR9 measured by immunohistochemistry reverse transcription-quantitative polymerase chain reaction analysis, respectively. results showed that TLR2,...
At present, natural orifice specimen extraction surgery (NOSES) has attracted more and attention worldwide, because of its great advantages including minimal cutaneous trauma post-operative pain, fast recovery, short hospital stay, positive psychological impact. However, NOSES for the treatment gastric cancer (GC) is still in infancy, there potential to improve theoretical system clinical practice. Especially, several key points oncological outcomes, bacteriological concerns, indication...
To compare the efficacy and feasibility of endoscopic retrograde appendicitis therapy (ERAT) with appendectomy for treating acute uncomplicated appendicitis.This was a prospective multicenter randomized trial in which consecutive patients were at ratio 1:1 to receive either ERAT or appendectomy. The outcomes included technical success rate, procedure time, postoperative pain relief, analgesic use, time soft diet intake, length hospital stay, complications, recurrence rate.From August 2013...