A5105514274- Pomegranate: compositions and health benefits
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Diet and metabolism studies
- Nuts composition and effects
- Sesame and Sesamin Research
- Obesity and Health Practices
- Gut microbiota and health
- Horticultural and Viticultural Research
- Cynara cardunculus studies
- Garlic and Onion Studies
- Tannin, Tannase and Anticancer Activities
- Nutrition, Genetics, and Disease
- Pharmacological Effects of Natural Compounds
- Obesity, Physical Activity, Diet
- Ginkgo biloba and Cashew Applications
- Microbial Metabolism and Applications
- Natural Antidiabetic Agents Studies
- Nutrition and Health in Aging
- Cancer Risks and Factors
- Biological Activity of Diterpenoids and Biflavonoids
- Tea Polyphenols and Effects
University of California, Los Angeles
2014-2023
Center for Human Genetics
2008-2023
Los Angeles Medical Center
2021
UCLA Health
2009-2020
Los Angeles City College
2015-2020
VA Greater Los Angeles Healthcare System
2013
University of Southern California
2013
Duke Medical Center
2011
Clinical Research Management
2011
University of Rhode Island
2011
Berry fruits are widely consumed in our diet and have attracted much attention due to their potential human health benefits. Berries contain a diverse range of phytochemicals with biological properties such as antioxidant, anticancer, anti-neurodegerative, anti-inflammatory activities. In the current study, extracts six popularly berriesblackberry, black raspberry, blueberry, cranberry, red raspberry strawberrywere evaluated for phenolic constituents using high performance liquid...
A number of different beverage products claim to have antioxidant potency due their perceived high content polyphenols. Basic and applied research indicates that pomegranate juice (PJ), produced from the Wonderful variety Punica granatum fruits, has strong activity related health benefits. Although consumers are familiar with concept free radicals antioxidants, they often misled by claims superior beverages, which usually based only on testing a limited spectrum activities. There is no...
Cranberries (Vaccinium macrocarpon Ait.) are an excellent dietary source of phytochemicals that include flavonol glycosides, anthocyanins, proanthocyanidins (condensed tannins), and organic phenolic acids. Using C-18 Sephadex Lipophilic LH-20 column chromatography, HPLC, tandem LC-ES/MS, the total cranberry extract (TCE) has been analyzed, quantified, separated into fractions enriched in sugars, acids, polyphenols, proanthocyanidins, anthocyanins (39.4, 30.0, 10.6, 5.5, 1.2% composition,...
Studies suggest that consumption of berry fruits, including strawberries ( Fragaria x ananassa Duch.), may have beneficial effects against oxidative stress mediated diseases such as cancer. Berries contain multiple phenolic compounds, which are thought to contribute their biological properties. Comprehensive profiling phenolics from was previously reported using high-performance liquid chromatography with mass spectrometry (HPLC-MS) detection. The current study reports the isolation and...
Because curcumin's anti-inflammatory properties may protect the brain from neurodegeneration, we studied its effect on memory in non-demented adults and explored impact amyloid tau accumulation using 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile positron emission tomography (FDDNP-PET).Forty subjects (age 51-84 years) were randomized to a bioavailable form of curcumin (Theracurmin® containing 90 mg twice daily [N = 21]) or placebo (N 19) for 18 months....
This study was conducted to determine the tolerance and effects of prebiotic xylooligosaccharide (XOS) on composition human colonic microbiota, pH short chain fatty acids (SCFA) in order whether significant changes microbiota would be achievable without side effects. Healthy adult subjects (n = 32) were recruited a double-blind, randomized, placebo-controlled study. Subjects received 1.4 g XOS, 2.8 XOS or placebo daily doses. The consisted 2 week run-in, an 8 intervention, washout phase....
Our group has shown in a phase II clinical trial that pomegranate juice (PJ) increases prostate specific antigen (PSA) doubling time cancer (CaP) patients with rising PSA. Ellagitannins (ETs) are the most abundant polyphenols present PJ and contribute greatly towards its reported biological properties. On consumption, ETs hydrolyze to release ellagic acid (EA), which is then converted by gut microflora 3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one (urolithin A, UA) derivatives. Despite...
The consumption of pomegranate juice (PJ), a rich source antioxidant polyphenols, has grown tremendously due to its reported health benefits. Pomegranate extracts, which incorporate the major antioxidants found in pomegranates, namely, ellagitannins, have been developed as botanical dietary supplements provide an alternative convenient form for consuming bioactive polyphenols PJ. Despite commercial availability extract supplements, there no studies evaluating their safety human subjects. A...
Abstract Purpose: To determine whether altering the dietary content of ω-6 (n-6) and ω-3 (n-3) polyunsaturated fatty acids affects growth androgen-sensitive prostate cancer xenografts, tumor membrane acid composition, cyclooxygenase-2 prostaglandin E2 (PGE2) levels. Experimental Design: Individually caged male severe combined immunodeficiency mice were fed isocaloric 20% kcal fat diets with derived either primarily from n-6 (n-6 group) or consisting n-3 in a ratio 1:1 (n-3 group), injected...
Pomegranate juice (PJ), a rich source of polyphenols including ellagitannins, has attracted much attention due to its reported health benefits. This resulted in the consumption liquid and powder pomegranate extracts as alternatives PJ. Therefore establishing bioavailability from these extract preparations is necessary. Sixteen healthy volunteers sequentially consumed, with 1-week washout period between treatments, PJ (8 ounces, Wonderful fruit variety), polyphenol (POMxl, 8 ounces), (POMxp,...
It has been suggested that gut microbiota is altered in Type 2 Diabetes Mellitus (T2DM) patients.This study was to evaluate the effect of prebiotic xylooligosaccharide (XOS) on both healthy and prediabetic (Pre-DM) subjects, as well impaired glucose tolerance (IGT) Pre-DM.Pre-DM (n = 13) or 16) subjects were randomized receive g/day XOS placebo for 8-weeks. In Pre-DM body composition oral test (OGTT) done at baseline week 8. Stool from 8 analyzed characterization using Illumina MiSeq...
The California Hass avocado ( Persea americana ) is an example of a domesticated berry fruit that matures on the tree during its growing season but ripens only after being harvested. Avocados are typically harvested multiple times in California. Previous research has demonstrated potential health benefits avocados and extracts against inflammation cancer cell growth, seasonal variations phytochemical profile fruits studied may affect results obtained future research. Therefore, present...
The health benefits of pomegranate (POM) consumption are attributed to ellagitannins and their metabolites, formed absorbed in the intestine by microbiota.
Objective: There is a widely held view that, due to high fat content, snacking on nuts will lead weight gain, ultimately causing unhealthy changes in lipid profiles. This study designed the effects of pistachio snack consumption body and levels obese participants under real-world conditions.Methods: Participants were randomly assigned consume 1 2 isocaloric reduction diets for 12 weeks, with each providing 500 cal per day less than resting metabolic rate. Each diet included an afternoon...
The gut microbiota is an important contributor to human health. Vegetable/fruit juices provide polyphenols, oligosaccharides, fiber and nitrate (beet juice), which may induce a prebiotic-like effect. Juice-based diets are becoming popular. However, there lack of scientific evidence their health benefits. It was our hypothesis that changes in the intestinal induced by juice-based diet play role Twenty healthy adults consumed only vegetable/fruit for 3 days followed 14 customary diet. On day 4...
Pomegranate extract (PE) inhibits the proliferation of breast cancer cells and stimulates apoptosis in MCF-7 cells. While PE is a potent antioxidant, present studies were conducted to examine mechanisms action beyond antioxidation by studying cellular molecular underlying tumorigenesis. inhibited cell growth inducing cycle arrest G2/M followed induction apoptosis. In contrast, antioxidants N-acetylcysteine Trolox did not affect at doses containing equivalent antioxidant capacity as PE,...