A5100631197- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traditional Chinese Medicine Studies
- Medical Research and Treatments
- Traditional Chinese Medicine Analysis
- Respiratory Support and Mechanisms
- Neurological Disease Mechanisms and Treatments
- Pediatric health and respiratory diseases
- Genetic Mapping and Diversity in Plants and Animals
- Acupuncture Treatment Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Metabolomics and Mass Spectrometry Studies
- Genetics and Plant Breeding
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Plant-based Medicinal Research
- Immune Response and Inflammation
- Medicinal Plant Pharmacodynamics Research
- Respiratory and Cough-Related Research
- Lung Cancer Treatments and Mutations
- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Gastric Cancer Management and Outcomes
- Wheat and Barley Genetics and Pathology
- Genetic and phenotypic traits in livestock
First Affiliated Hospital of Henan University
2016-2025
Guangzhou Medical University Cancer Hospital
2012-2025
Guangzhou Medical University
2012-2025
Shanxi Academy of Medical Sciences
2023-2024
Shenyang University of Technology
2024
Gansu Provincial Hospital
2024
China Agricultural University
2004-2023
Weatherford College
2023
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2010-2022
Shanghai University of Traditional Chinese Medicine
2020-2022
Lipopolysaccharide (LPS), the major outer surface membrane component of Gram-negative bacteria, is one main etiological factors in pathogenesis several lung diseases, such as chronic obstructive pulmonary disease. The respiratory epithelium and macrophages comprise dynamic interface between outside environment host response to bacterial infection via cytokine secretion. In present study, mechanisms LPS induced‑inflammatory human cells were investigated. effects exposure on production,...
Abstract The present work adopted a systems pharmacology-based approach to provide new insights into the active compounds and therapeutic targets of Bufei Yishen formula (BYF) for treatment chronic obstructive pulmonary disease (COPD). In addition, we established rat model cigarette smoke- bacterial infection-induced COPD validate mechanisms BYF action that were predicted in pharmacology study. derived 216 from 195 potential related various diseases. compound-target network showed each...
Traditional Chinese medicine (TCM) has been used to treat chronic obstructive pulmonary disease (COPD) for many years. This study aimed evaluate the efficacy and safety of comprehensive therapy based on three common TCM patterns in stable COPD patients.A four-center, open-label randomized controlled method was conducted. A total 352 patients were divided into trial group (n = 176, treated with conventional Western Bu-Fei Jian-Pi granules, Yi-Shen Yi-Qi Zi-Shen granules respectively) control...
To develop a stable chronic obstructive pulmonary disease (COPD) model in rats. Sprague-Dawley rats were treated with cigarette-smoke inhalation (CSI) for 12 weeks, repetitive bacterial infection (RBI) 8 or the combination of two (CCR) weeks and followed up additional 20 weeks. Tidal volume (VT), peak expiratory flow (PEF) 50% VT (EF50), histological changes lungs, levels cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-8, IL-10 serum bronchial alveolar lavage fluid (BALF) examined...
Nobiletin is a natural polymethoxylated flavonoid widely present in citrus fruit peels. It has been extensively studied due to its wide range of pharmacological activities and considered potential therapeutic drug for various diseases. demonstrated exert the effects anti-tumor, anti-inflammation, anti-oxidative, anti-apoptotic improve cardiovascular function. Increasing evidences suggest that nobiletin plays an important role respiratory diseases (RDs) treatment. This review aimed...
Among cereals, only maize has not a high amount of carotenoids, tocopherols, and oil content but also is rich in starch protein compared with other major food crops, such as rice wheat. The present investigation was made primarily to assess the genetic variability for nutritionally important traits 87 elite inbreds representing heterotic groups China. Carotenoid tocopherol fractions were measured by high-performance liquid chromatography (HPLC), whereas oil, starch, contents detected...
Bufei Yishen formula (BYF) is a traditional Chinese medicine formula, which has long been used as therapeutic agent for the treatment of chronic obstructive pulmonary disease (COPD). Systems pharmacology previously to identify potential targets BYF, and an experimental study demonstrated that BYF able prevent COPD. In addition, transcriptomic metabolomic profiles lung tissues from rats with COPD BYF‑treated have characterized. The present aimed determine mechanisms underlying effects on by...
(1) Background: Rhubarb anthraquinones-a class of components with neuroprotective function-can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and infarction area; UPLC-MS/MS was in pharmacokinetic studies detect plasma concentrations at different time points, DAS software calculate parameters a noncompartmental model. (3) Results: results showed that the pharmacodynamics...
Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated the development of chronic obstructive pulmonary disease (COPD). The mechanisms by which PM2.5 accelerates progression in COPD are poorly understood. In this study, we aimed to investigate effect on lung injury rats hallmark features COPD. Cardinal human were induced a rat model repeated cigarette smoke inhalation and bacterial infection for 8 weeks. Then, from week 9 16, some these...
ABSTRACT Background Patient‐reported outcomes (PROs) have become indispensable measures in allergic rhinitis (AR) clinical trials. However, there is currently no scale specifically designed for the Chinese population. This study aimed to develop and validate patient‐reported outcome (AR‐PRO) provide a reliable tool AR patients China. Methods We analyzed relevant literature medical records, conducted interviews panel discussions conceptual framework generate item pool. subjected collected...