A5101517707- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Oral Health Pathology and Treatment
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- PI3K/AKT/mTOR signaling in cancer
- Renal cell carcinoma treatment
- DNA Repair Mechanisms
- Bioactive Compounds and Antitumor Agents
- Sarcoma Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Metastasis and carcinoma case studies
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Infectious Diseases and Mycology
- Systemic Lupus Erythematosus Research
- RNA Research and Splicing
- interferon and immune responses
- Drug Transport and Resistance Mechanisms
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
Second Affiliated Hospital of Zhejiang University
2024
Nanjing Medical University
2022
Nanjing University
2022
First Affiliated Hospital of Anhui Medical University
2021-2022
Anhui Medical University
2010-2022
Nanjing Drum Tower Hospital
2022
Sir Run Run Shaw Hospital
2018
Zhejiang University
2018
Anhui Provincial Hospital
2010-2011
Gastric cancer is the fifth most diagnosed malignant tumor worldwide with limited effective chemotherapy. Ferroptosis a new type of programmed cell death, which becoming as novel therapeutic target for tumors. Arenobufagin (ArBu) bufadienolide isolated from toad skin and venom, exhibits broad-spectrum anti-tumor activity. It unclear whether ArBu causes ferroptosis, thereby exhibiting activity in gastric cancer. We aimed to determine ferroptosis cultured human cells.Different cells were...
Retinoid-related orphan receptor alpha (RORα) and nuclear subfamily 1 group D member (REV-ERBα) play critical roles in many human cancers. Whether RORα REV-ERBα expression levels are associated with clinical characteristics poorly understood, they may be independent predictors of overall survival (OS) progression-free (PFS) gastric cancer (GC). This study aimed to investigate the correlation clinicopathological parameters, OS, PFS GC. Immunohistochemistry quantitative reverse...
Mast cells (MCs) are widely distributed in the gastrointestinal tract, which could be involved visceral hypersensitivity and gut dysmotility. Whether esophageal MCs play a role non-erosive reflux disease (NERD) has yet to determined. The aim of this study was characterize distribution, degranulation, ultrastructure.The mucosa at 5 cm above end esophagus obtained from 26 NERD 14 healthy volunteers (control) by gastroscopy. Immunohistochemistry performed average MC counts per high-power field...
Purpose: This study aimed to construct a novel signature predict the survival of patients with colon cancer and associated immune landscape, based on immune-related long noncoding ribonucleic acids (irlncRNAs). Methods: Expression profiles irlncRNAs in 457 were retrieved from TCGA database (https://portal.gdc.cancer.gov). Differentially expressed (DE) identified irlncRNA pairs recognized using Lasso regression Cox analyses. Akaike information criterion (AIC) values receiver operating...
The present study aimed to determine the potential of carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), carbohydrate (CA)19-9 and CA242 in predicting recurrence/metastasis gastric cancer patients following radical gastrectomy. clinical data 368 with stage I-III who underwent gastrectomy were analyzed, CEA, AFP, CA19-9 levels detected prior surgery 6-12 months surgery. Univariate multivariate analyses used evaluate risk factors for post-operative cancer, predictive value was evaluated...
We reported that Rev-erbα, a transcriptional repressor, is reduced in human gastric cancer and it inhibits glycolysis cultured cells. However, unclear whether Rev-erbα undergoes posttranslational modifications cancer. Here, we determined levels of its including phosphorylation, SUMOylation, ubiquitination N-methyl-N-nitrosourea (MNU)/Helicobacter pylori (H. pylori)-induced mice Administration MNU plus H. infection successfully induced tumor C57BL/6J mice. MNU/H. decreased the tissues...
Objective To immunize pristane-induced BALB/c mouse models for lupus with MCP-1 DNA vaccine, and to study the immunosuppressive effect protective on kidney of vaccine in murine model.Methods mice were randomly divided into four groups.Pristane-induced immunized vaccine(MCP-1 group), empty plasmids(empty plasmid control group)or remained non-vaccinated(lupus model group).Normal receiving neither induction nor vaccination served as normal control.Subsequently, monitored body weight 24-hour...
Objective To investigate the expression of neural-nitric oxide synthase (nNOS) in renal clear cell carcinoma and its clinical significance. Methods The nNOS mRNA 533 samples TCGA database was analyzed with Student t test, statistical analysis performed to assess relationship between prognosis Kapla-Meier test. Western blot protein 10 cases carcinoma(ccRCC) from department urology Wuhan union hospital student test. Results The levels 72 ccRCC tumor tissues adjacent were 2.99±0.28...