A5031972329- Genetic Mapping and Diversity in Plants and Animals
- Viral Infections and Immunology Research
- GABA and Rice Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Rice Cultivation and Yield Improvement
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Plant Disease Resistance and Genetics
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Renal Diseases and Glomerulopathies
- Virology and Viral Diseases
- Bone Metabolism and Diseases
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Microbial infections and disease research
- Plant Pathogenic Bacteria Studies
- Pneumonia and Respiratory Infections
Sichuan Agricultural University
2011-2025
Ministry of Education of the People's Republic of China
2024-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Science and Technology Department of Sichuan Province
2025
The University of Sydney
1999-2024
Westmead Institute for Medical Research
2020-2024
University of South China
2023-2024
Southwest Jiaotong University
2024
Southwest Jiaotong University Hope College
2024
Beijing Normal University
2024
Background Porcine circovirus type 2 (PCV2) is considered to be the primary causative agent of postweaning multisystemic wasting syndrome (PMWS), which has become a serious economic problem for swine industry worldwide. The major genotypes, PCV2a and PCV2b, are highly prevalent in pig population present However, another newly emerging PCV2b genotype mutant, mutation its ORF2-encoded capsid protein, been sporadically China, as well other countries. It therefore important determine relative...
Rice blast disease is one of the most serious and recurrent problems in rice-growing regions worldwide. Most resistance genes were identified by linkage mapping using genetic populations. We extensively examined 16 rice strains a further genome-wide association study based on genotyping 0.8 million single nucleotide polymorphism variants across 366 diverse indica accessions.Totally, thirty associated loci identified. The strongest signal (Chr11_6526998, P =1.17 × 10-17) was located within...
ABSTRACT To evaluate vaccine efficacy in protecting against coxsackievirus A16 (CA16), which causes human hand, foot, and mouth disease (HFMD), we established the first neonatal mouse model. In this article, report data concerning CA16-induced pathological changes, demonstrate that anti-CA16 antibody can protect mice lethal challenge model could be used to efficacy. establish a model, BJCA08/CA16 strain (at 260 50% doses [LD 50 ]) was isolated from patient intracerebrally (i.c.) inoculate...
Increasing rice (Oryza sativa L.) yield is a crucial challenge for modern agriculture. The ideal plant architecture considered to be critical enhance yield. Elite morphological traits should include compact type, short stature, few unproductive tillers, thick and sturdy stems erect leaves. To reveal the genetic variations of important traits, 523 germplasm accessions were genotyped using Illumina custom-designed array containing 5,291 single nucleotide polymorphisms (SNPs) phenotyped in two...
Rice (Oryza sativa L.) is the only cereal crop that possesses ability to germinate under flooded or other oxygen-deficient conditions. Rapid elongation of coleoptile a perfect response flooding during germination, with length differing among various rice varieties. Despite multiple studies have uncovered valuable information concerning this trait by focusing on physiological metabolism oxygen stress, underlying genetic mechanism still remains unknown. In present study, we screened lengths...
Recent studies have identified circular RNAs (circRNAs) expressed from the Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) human DNA tumor viruses. To gain initial insights into potential relevance of EBV circRNAs in biology disease, we assessed circRNAome interspecies homologue rhesus macaque lymphocryptovirus (rLCV) a naturally occurring lymphoma simian immunodeficiency (SIV)-infected macaque. This analysis revealed rLCV orthologues latency-associated circRPMS1_E4_E3a...
ObjectiveThe risk factors and the impact of NAI treatments in patients with severe influenza A-associated pneumonia remain unclear.MethodsA multicenter, retrospective, observational study was conducted Zhejiang, China during a epidemic August 2017–May 2018. Clinical records (>14 y) hospitalized laboratory-confirmed A virus infection who developed were compared to those mild-to-moderate pneumonia. Risk related severity effects (monotherapy combination peramivir oseltamivir)...
Gammaherpesviruses are an important class of oncogenic pathogens that exquisitely evolved to their respective hosts. As such, the human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV) do not naturally infect nonhuman primates or rodents. There is a clear need fully explore mechanisms gammaherpesvirus pathogenesis, host control, immune evasion in host. A pathogen isolated from murid rodents was first reported 1980; 40 years later, murine 68 (MHV68, MuHV-4,...
Totally, 23 loci were detected, and 383 candidate genes identified, four of these genes, Os01g0392100, Os04g0630000, Os01g0904700 Os07g0615000 , regarded as promising targets. Direct-seeding cultivation is becoming popular in rice (Oryza sativa L.)-planting countries because it labor- time-efficient. However, low seedling establishment slow emergence have restricted the application popularity technique. Mesocotyl elongation shoot length are two important traits that can enhance emergence. A...
The mechanism underlying how transcription factors regulate mesenchymal stem cell lineage commitment remains unclear. To determine the role of core-binding factor subunit beta (Cbfβ) in osteoblast commitment, we generated three mouse models by deleting
A region containing three genes on chromosome 1 of indica rice was associated with cold tolerance at the bud burst stage; these results may be useful for breeding cold-tolerant lines. Low temperature stage is one major abiotic stresses limiting growth, especially in regions where seeds are sown directly. In this study, we investigated and conducted a genome-wide association study (GWAS) based 5K array 249 varieties widely distributed China. We improved method to assess rice, used severity...
ABSTRACT Porcine deltacoronavirus (PDCoV) is an enteric pathogen that burdens the global pig industry and a public health concern. The development of effective antiviral therapies necessary for prevention control PDCoV, yet to date, there are few studies on therapeutic potential PDCoV-neutralizing antibodies. Here, we investigate novel monoclonal antibody (mAb 4A6) which targets PDCoV S1 protein effectively neutralizes both pre- post-attachment cells, with IC50 values 0.537 8.487 µg/mL,...
Background The Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is known for its capacity to cause severe neurological disease in Asia. Neurotropic flaviviruses within the (JE) serogroup possess distinctive feature of expressing unique nonstructural protein, NS1′. NS1′ protein consists full NS1 with an additional 52 amino acid extension at C-terminus and has been demonstrated exhibit virulence mammalian hosts upon infection. However, precise role mosquito vectors yet be...
Background: Rice (Oryza sativa L.) is the staple food of more than half world's population.The identification genetic diversity in local varieties rice compared with that improved or introduced important breeding elite for sustainable agriculture.Array-based single nucleotide polymorphism (SNP) detection a useful technique such studies and applications.Results: We developed 5291-SNP genome-wide array used it to genotype 471 indica accessions China using Illumina's Infinium technology.Local,...
Herpangina (HA) and hand, foot, mouth disease (HFMD) are common infectious diseases caused by human enteroviruses frequently occurr in young children. Previous published studies have mainly focused on HFMD, while the HA epidemiological etiological characteristics mainland China not been described. From June, 2013 to March, 2014, HFMD patients were monitored participants from clinical trial of EV-A71 vaccine conducted during 2012–2013. A total 95 161 defined. Enteroviruses samples...