Bufei Yishen formula (BYF) is a traditional Chinese medicine formula, which has long been used as therapeutic agent for the treatment of chronic obstructive pulmonary disease (COPD). Systems pharmacology previously to identify potential targets BYF, and an experimental study demonstrated that BYF able prevent COPD. In addition, transcriptomic metabolomic profiles lung tissues from rats with COPD BYF‑treated have characterized. The present aimed determine mechanisms underlying effects on by...

Background and Aims NASH is an increasingly prevalent disease that the major cause of liver dysfunction. Previous research has indicated adipose cardiolipin synthase 1 (CRLS1) levels are associated with insulin sensitivity; however, precise roles CRLS1 underlying mechanisms involving in pathological process have not been elucidated. Approach Results Here, we discovered was significantly down‐regulated genetically obese diet‐induced mice models. In vitro studies demonstrated overexpression...

The purpose of this second special issue is to build on and extend the development Deliberative Policy Analysis (DPA) 2.0 that was set in motion by first DPA journal. It up around a symposium focused integrating DPA’s pillars interpretation, practice, deliberation. We identify three key threads for interweaving these advancing introduce five other contributions along lines. conclude offers range solid progressive approaches methodically engaging with complexity, relationality practical...

Abstract System pharmacology identified 195 potential targets of Bufei Yishen formula (BYF) and BYF was proven to have a short-term therapeutic effect on chronic obstructive pulmonary disease (COPD) rats previously. However, the long-term mechanism COPD is still unclear. Herein, we explored its underlying at system level. We administered from week 9 20 found that could prevent by inhibiting inflammatory cytokines expression, protease-antiprotease imbalance collagen deposition 32. Then, using...

It has been 15 years since Hajer and Wagenaar published Deliberative Policy Analysis (hereafter DPA). The book’s publication was one of the major developments in post-positivist policy movement...

Background: The Chinese herbal Bufei Jianpi formula (BJF) provides an effective treatment option for chronic obstructive pulmonary disease (COPD). However, the systems-level mechanism underlying clinical effects of BJF on COPD remains unknown. Methods: In this study, a systems pharmacology model based absorption filtering, network targeting, and analyses was applied specifically to clarify active compounds therapeutic mechanisms BJF. Then, rat cigarette smoke- bacterial infection-induced...

Deliberative policy analysis (DPA) has become a new branch of post-positivist inquiry since the release book edited by Hajer and Wagenaar fifteen years ago. The status quo this field, however, is not satisfactory. Particularly, there apparent shortage exploration on how to apply DPA generate insights for making. This article undertakes critical revisit DPA’s development explore road ahead, especially through lens practice. It starts with brief review study, mainly focusing its...

Deliberative policy analysis (DPA), which embraces increased public involvement and rejects technocracy, seems naturally to be connected democratic political systems. Why, then, how has DPA developed in China, an authoritarian country? This forum piece takes experimental research methodology (EPRM), a localized version of as embodiment this depicts the political, institutional, disciplinary landscape been conducted China from historical perspective. The essay introduces EPRM's basic...

Systems thinking (ST) and conflict resolution (CR) have much to gain from mutual informing learning. This review article attempts introduce the systems community research practice of CR. It outlines strands, development frontiers CR analyzes its relevance similarities with ST. The then discusses implications for further research. Copyright © 2012 John Wiley & Sons, Ltd.

Abstract There are some challenges for policy making in current Chinese context. Interest groups can hardly find any institutionalized channel to express their concerns. The lack of organized public participation obstructs the structuring a focused, thorough debate interest‐based options. Policy makers both methods and ability clarify contradictory evidence interwoven with interest conflicts debates. Systems methodology could be good remedy. This paper discusses these challenges, presents...

As we showed in the Introduction to this special issue (Li and Wagenaar 2019), since publication of seminal work (Hajer 2003), Deliberative Policy Analysis (DPA) has enjoyed co...

Abstract Scientific research and productive practice for earth history are inseparable from the accurate stratigraphic framework time framework. Establishing globally unified, precise reliable chronostratigraphic series geological is major goal of International Commission on Stratigraphy (ICS). Under leadership ICS, countries around world have carried out Global Standard Stratotype‐section Points (GSSPs) boundaries systems. In current Chronostratigraphic Chart (ICC), 65 GSSPs been erected in...

This study aims to discuss the differential diagnosis value of endometrial volume and flow parameters in combination with serum carbohydrate antigen 125 (CA125) benign malignant lesions. The data 250 patients lesions were retrospectively analyzed. Carbohydrate was determined before operation. morphology, hemodynamics, endometrium measured by transvaginal three-dimensional-power Doppler angiography (3D-PDA). (EV), 3D-PDA vascular index (VI), (FI) vascularization (VFI) calculated using virtual...

An accurate analysis of the relationship between humans and land in oasis areas is essential for formulation policies differentiated urban development resource management measures. Therefore, researchers have conducted numerous studies based on linear “people land” areas. To address this gap, paper takes Wuwei as an example re-examines impact human activities sustainability natural capital from a new research perspective (nonlinear perspective). The study selected four variables, namely...

Sonographic features of umbilical vein recanalization for a Rex shunt on cavernous transformation portal in children

The DC bias current invading into the transformer neutral point is generated by high voltage direct transmission system and geomagnetic storm, which will cause a half wave saturation of core flux threaten safe stable operation power system. experiment made our research group based on 1000kV UHV autotransformer in dependently developed China, adverse effects autotransformers under event such as distortion rate, harmonic component excitation reactive fluctuation are simulated analyzed....

Understanding all the possibilities of environmentally oriented landscape planning will contribute to effective environmental territory and nature management in general. Accordingly, purpose study was investigate experience European countries towards introduction an system improvement territories, as well their protection. For this purpose, it is necessary comprehensively strengths weaknesses existing developments field Europe. An analysis best practices such Great Britain, France, Germany,...

In an information society, government is not only a major social resource, but also indispensable welfare resource.Government disclosure of great significance in terms welfare.It held by the author that observation and study on from perspective may promote development public administration while improving level welfare.