A5044058316- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Kruppel-like factors research
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Long-Term Effects of COVID-19
- AI in cancer detection
- SARS-CoV-2 and COVID-19 Research
- Pluripotent Stem Cells Research
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Bacteriophages and microbial interactions
- Hippo pathway signaling and YAP/TAZ
- Metastasis and carcinoma case studies
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Viral-associated cancers and disorders
- Caveolin-1 and cellular processes
Southern University of Science and Technology
2018-2024
Shenzhen Third People’s Hospital
2017-2024
Tianjin Medical University General Hospital
2024
Jinan City People's Hospital
2021
Shandong First Medical University
2021
Chung Shan Medical University Hospital
2019
Southern Medical University
2011-2018
Guangdong Medical College
2007-2017
Peking University Shenzhen Hospital
2016
Nanfang Hospital
2014
Expression of embryonic stem cells (ESCs) markers (SOX2, OCT4, Nanog and Nestin) is crucial for progression various human malignancies. The purpose this study was to investigate the expression prognostic impact these molecules in nasopharyngeal carcinoma (NPC) patients by immunohistochemistry immunofluorescence. In present study, we found that levels SOX2, OCT4 were highly expressed NPC compared with non-tumorous tissues. Furthermore, proteins correlated significantly several...
The aim of the present study was to analyze expression Zinc finger E-box Binding homeobox 2 (ZEB2) in glioma and explore molecular mechanisms ZEB2 that regulate cell proliferation, migration, invasion, apoptosis.Expression 90 clinicopathologically characterized patients analyzed by immunohistochemistry. Furthermore, siRNA targeting transfected into U251 U87 lines vitro apoptosis were examined separately MTT assay, Transwell chamber flow cytometry, western blot.The level protein significantly...
The aim of the present study was to analyze expression matrix metalloproteinase 9 (MMP9) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, including survival patients NPC.Using real-time PCR, we detected mRNA MMP9 normal tissues tissues. Using immunohistochemistry analysis, analyzed protein clinicopathologically characterized 164 NPC cases (116 male 48 female) age ranging from 17 80 years (median = 48.4 years) 32 Cases greater than or equal 6 less score...
A small subpopulation of cancer cells with stem cell-like features might be responsible for tumour generation, progression and chemoresistance. Hes1 influences the maintenance certain progenitor digestive systems. We found upregulated in poorly differentiated samples compared well-differentiated most adenocarcinomas exhibited significantly higher levels mRNA that observed matched normal colon samples. Moreover, expression was to correlated cell markers upregulates stemness-related genes...
Abstract Dysfunctional immune responses contribute critically to the progression of Coronavirus Disease-2019 (COVID-19), with macrophages as one main cell types involved. It is urgent understand interactions among permissive cells, macrophages, and SARS-CoV-2 virus, thereby offering important insights into effective therapeutic strategies. Here, we establish a lung macrophage co-culture system derived from human pluripotent stem cells (hPSCs), modeling host-pathogen interaction in infection....
Precise classification of histopathological images is crucial to computer-aided diagnosis in clinical practice. Magnification-based learning networks have attracted considerable attention for their ability improve performance classification. However, the fusion pyramids at different magnifications an under-explored area. In this paper, we proposed a novel deep multi-magnification similarity (DSML) approach that can be useful interpretation framework and easy visualize feature representation...
Abstract Background The aim of the present study was to analyze expression Cyclin-dependent kinase 4 ( CDK4 ) in lung cancer and its correlation with clinicopathologic features. Furthermore, involvement -mediated cell cycle progression molecular basis were investigated pathogenesis cancer. Methods Using immunohistochemistry analysis, we analyzed protein 89 clinicopathologically characterized patients (59 males 30 females) ages ranging from 36 78 years compared them 23 normal tissues. Cases...
Abstract Expression of vimentin and the epithelial to mesenchymal transition (EMT) markers E‐cadherin, β‐catenin is essential for progression various human cancers. Our study aimed investigate aberrant localization vimentin, their prognostic significance in 122 nasopharyngeal carcinoma (NPC) patients by immunohistochemistry immunofluorescence. results showed that both membranous cytoplasmic E‐cadherin staining were associated with lymph node metastasis ( p = 0.000 0.005, respectively)...
Luo W‐R, Gao F, Li S‐Y & Yao K‐T (2012) Histopathology Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma Aims: To detect prognostic significance tumour its (ALDH1) (NPC). Methods results: was investigated 105 patients with NPC by immunohistochemistry for pan‐cytokeratin (AE1/AE3). The intensity correlated strongly T classification ( P = 0.008), lymphatic invasion < 0.001), vascular 0.029), lymph node metastasis clinical...
Overexpression of the transcriptional factor Hes1 (hairy and enhancer split-1) has been observed in numerous cancers, but precise roles epithelial-mesenchymal transition (EMT), cancer invasion metastasis remain unknown. Our current study firstly revealed that upregulation a cohort human nasopharyngeal carcinoma (NPC) biopsies is significantly associated with EMT, invasive metastatic phenotypes cancer. In present study, we found overexpression triggered EMT-like cellular marker alterations...
Abstract Background Children and older adults with coronavirus disease 2019 (COVID-19) display a distinct spectrum of severity yet the risk factors aren’t well understood. We sought to examine expression pattern angiotensin-converting enzyme 2 (ACE2), cell-entry receptor for severe acute respiratory syndrome (SARS-CoV-2), role lung progenitor cells in children patients. Methods retrospectively analyzed clinical features cohort 299 patients COVID-19. The distribution ACE2 were systematically...
Abstract Background In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, mechanisms underlying resistance are still poorly understood. this study, we investigated roles cold‑inducible RNA binding protein (Cirbp) in regulating and nasopharyngeal carcinoma (NPC). Methods CCK-8 assay, colony formation tumor sphere qRT-PCR, Western blot were employed to examine effects (HT), HT + oridonin(Ori) or radiotherapy...
Background The self-renewal and tumourigenicity of FoxM1 in nasopharyngeal carcinoma (NPC) remain largely unknown. In this study, we attempt to investigate the its clinical significance (NPC). Methods Several assays including cell counting Kit-8 (CCK-8) assays, colony formation, flow cytometry, immunofluorescence, tumor spheres mice model were used detect biological function NPC. association between clincalpathological features, stem markers was analyzed using immunohistochemistry. Results...
Luo W‐R, Chen X‐Y, Li S‐Y, Wu A‐B & Yao K‐T (2012) Histopathology 61, 113–122 Neoplastic spindle cells in nasopharyngeal carcinoma show features of epithelial–mesenchymal transition Aim: To investigate whether the neoplastic (NPC) are associated with process (EMT). Methods and results: We used immunohistochemistry to analyse expression cytokeratin, E‐cadherin, β‐catenin, vimentin, fibronectin, Snail1, Slug aldehyde dehydrogenase 1 (ALDH1) 115 cases NPC which there were cells; 47 a...
Up to now, the precise molecular and morphological changes underlying invasive metastatic properties of nasopharyngeal carcinoma (NPC) remain largely unresolved. We speculate that neoplastic spindle cells, which are prominently found in tumor front surrounding stroma, might be responsible for aggressive patterns. Expression profiling various biomarkers relevant cancer stem cells (CSCs) epithelial-mesenchymal transition (EMT) was performed by tissue microarray-based immunohistochemistry NPC...
The mechanisms of self-renewal and pluripotency maintenance human pluripotent stem cells (hPSCs) have not been fully elucidated, especially for the role those poorly characterized long noncoding RNAs (lncRNAs).ESRG is a lncRNA highly expressed in hPSCs, its functional roles are being extensively explored field.Here, we identified that transcription ESRG can be directly regulated by OCT4, key factor hPSCs.Knockdown induces hPSC differentiation, cell cycle arrest, apoptosis.ESRG binds to MCM2,...
Luo W‐R, Wu A‐B, Fang W‐Y, Li S‐Y & Yao K‐T (2012) Histopathology 61, 237–246 Nuclear expression of N‐cadherin correlates with poor prognosis nasopharyngeal carcinoma Aims: To investigate the aberrant in (NPC) and its prognostic significance. Methods results: Immunohistochemical staining for protein was performed on tissue microarray (TMA) from 122 NPC patients. Cytoplasmic observed 42.6% nuclear 45.1% tissues. High cytoplasmic associated a majority clinicopathological variables,...