A5081730905- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Testicular diseases and treatments
- X-ray Diffraction in Crystallography
- Fibroblast Growth Factor Research
- Connective Tissue Growth Factor Research
- Crystallization and Solubility Studies
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Pituitary Gland Disorders and Treatments
- Spinal Dysraphism and Malformations
- PARP inhibition in cancer therapy
- Crystallography and molecular interactions
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Brain Metastases and Treatment
- Epigenetics and DNA Methylation
Guangzhou Medical University
2024-2025
Guangzhou Women and Children Medical Center
2025
Southern Medical University
2015-2024
Nanfang Hospital
2015-2024
Ganzhou People's Hospital
2022
The First Affiliated Hospital, Sun Yat-sen University
2019
Sun Yat-sen University
2019
Guangzhou University of Chinese Medicine
2019
Zhongshan Hospital
2019
University of Toronto
2013
Abstract Background The success of using glycolytic inhibitors for cancer treatment relies on better understanding the roles each frequently deregulated genes in cancer. This report analyzed involvement a key enzyme, alpha-enolase (ENO1), tumor progression and prognosis human glioma. Methods ENO1 expression levels were examined glioma tissues normal brain (NB) tissues. molecular mechanisms its effects cell growth, migration invasion also explored by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl...
The aim of the present study was to analyze expression Zinc finger E-box Binding homeobox 2 (ZEB2) in glioma and explore molecular mechanisms ZEB2 that regulate cell proliferation, migration, invasion, apoptosis.Expression 90 clinicopathologically characterized patients analyzed by immunohistochemistry. Furthermore, siRNA targeting transfected into U251 U87 lines vitro apoptosis were examined separately MTT assay, Transwell chamber flow cytometry, western blot.The level protein significantly...
Programmed cell death 4 (PDCD4), a novel tumor suppressor, inhibits proliferation, migration and invasion as well promotes apoptosis in tumors. However, the molecular mechanism of its tumor-suppressive function remains largely unknown tumors including nasopharyngeal carcinoma (NPC). In this study, downregulated PDCD4 expression was significantly associated with status NPC progression poor prognosis. markedly suppressed ability proliferation survival by modulating C-MYC-controlled cycle...
// Ye Song 1, * , Shihao Zheng Jizhou Wang Hao Long 1 Luxiong Fang Gang Zhiyong Li Tianshi Que Yi Liu Yilei 2 Xi'an Zhang Weiyi 3 and Songtao Qi Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, PR China Pharmacology, Cancer Center, TCM-Integrated University These authors contributed equally to this work Correspondence to: Zhang, email: zxa@smu.edu.cn Fang, fangweiyi1975@163.com Qi, qisongtaosjwk@163.com Keywords: PLOD2, glioma,...
Oxidative stress due to Cu2+-triggered aggregation of β-amyloid protein (Aβ) and reactive oxygen species (ROS) overexpression in the brain is an important hallmark early stages Alzheimer's disease (AD) pathogenesis. The ideal modulator for improving oxidative microenvironment AD brains should take both Cu2+ ROS into consideration, which has been rarely reported. Here, a combined therapeutic strategy was achieved by co-encapsulating superoxide dismutase (SOD) catalase (CAT) imine-linked...
Amplification of chromosome 7p11 (7p11) is the most common alteration in primary glioblastoma (GBM), resulting gains epidermal growth factor receptor ( EGFR ) copy number 50 to 60% GBM tumors. However, treatment strategies targeting have thus far failed clinical trials, and underlying mechanism remains largely unclear. We here demonstrate that amplification at locus frequently encompasses its neighboring genes identifies SEC61G as a critical regulator facilitating immune evasion tumor...
Connective tissue growth factor (CTGF) has different roles in types of cancer. However, the involvement and molecular basis CTGF tumor progression prognosis human nasopharyngeal carcinoma (NPC) have almost never been reported. In this study, we observed that downregulated expression was significantly associated with NPC poor prognosis. Knockdown markedly elevated ability cell proliferation vivo vitro. Subsequently, discovered reduction increased miR-18b, an oncomir-promoting proliferation....
Brain metastasis (BM) is a leading cause of death in patients with non-small cell lung cancer (NSCLC). EGFR mutations primary NSCLC lesions have been associated sensitivity to tyrosine kinase inhibitor (TKI). Therefore, it has become important understand mutation status BM NSCLC, and its clinical implications. samples 136 from South China, which 15 had paired tumors, were retrospectively analyzed for by amplification refractory system (ARMS). Effect on progression-free survival (PFS) overall...
Aging | doi:10.18632/aging.203805. Zigui Chen, Yingying Xie, Hongcheng Luo, Ye Song, Tianshi Que, Rentong Hu, Huatuo Huang, Kunxiang Chuanyu Li, Chengjian Qin, Chuanhua Zheng, Weiyi Fang, Longyang Liu, Hao Long, Qisheng Luo
Oxidative stress and neuronal apoptosis could be an important factor leading to post-hemorrhagic consequences after germinal matrix hemorrhage (GMH). Previously study have indicated that relaxin 2 receptor activation initiates anti-oxidative anti-apoptosis in ischemia-reperfusion injury. However, whether can attenuate oxidative GMH remains unknown. To investigate the beneficial effect of on injury by GMH, a total 150 rat pups were subjected intraparenchymal injection bacterial collagenase....
Understanding the mechanisms of glioblastoma at molecular and structural level is not only interesting for basic science but also valuable biotechnological application, such as clinical treatment. In present study, bioinformatics analysis was performed to reveal identify key genes multiforme (GBM). The results obtained in study signified importance some genes, COL3A1, FN1, MMP9, glioblastoma. Based on selected a prediction model built, which achieved 94.4% accuracy. These findings might...
Abstract Mesenchymal glioblastoma (GBM) is highly resistant to radio‐and chemotherapy and correlates with worse survival outcomes in GBM patients; however, the underlying mechanism determining mesenchymal phenotype remains largely unclear. Herein, it revealed that FBXO7, a substrate‐recognition component of SCF complex implicated pathogenesis Parkinson's disease, confers properties chemoresistance by controlling Rbfox2‐mediated alternative splicing. Specifically, FBXO7 ubiquitinates Rbfox2...
Phosphoenolpyruvate carboxykinase (PEPCK) plays a crucial role in gluconeogenesis, glycolysis, and the tricarboxylic acid cycle by converting oxaloacetate into phosphoenolpyruvate. Two distinct isoforms of PEPCK, specifically cytosolic PCK1 mitochondrial PCK2, have been identified. Nevertheless, comprehensive understanding their dysregulation pan-cancer potential mechanism contributing to signaling transduction pathways remains elusive.
Background The role of CTGF varies in different types cancer. purpose this study is to investigate the involvement tumor progression and prognosis human nasopharyngeal carcinoma (NPC). Experimental design expression levels were examined NPC tissues cells, nasopharynx (NP) tissues, NP69 cells. effects molecular mechanisms on cell proliferation, migration, invasion, cycle also explored. Results cells exhibited decreased mRNA compared immortalized epithelial line NP69. Similarly, was observed...
Glioblastoma has been identified as the most common and aggressive primary brain tumor in adults. Recently, it found that cisplatin (DDP) treatment is a chemotherapeutic method for GBM patients. circ_PTN (ID number: hsa_circ_0003949) newly circular (circRNA) which proved to be highly expressed cells, while its role remains unclear. Therefore, our study focused on investigating of DDP resistance cells. The expression DDP-sensitive DDP-resistant cells was detected assay. Functional experiments...
Bifidobacterium bifidum MIMBb75 is a recently identified probiotic. However, its distribution along the intestine and impact on resident microbiota unknown. Herein, we established quantitative real-time polymerase chain reaction assay targeting B. bifidum-specific BopA region for quantification of in feces used this to investigate transit through murine intestine. We also analyzed consequential microbial cohorts. C57BL/6J mice were daily gavaged with 0.2 mL either sterile PBS or containing...
Abstract Glioma has been a major healthcare burden; however, the specific molecular regulatory mechanism underlying its initiation and progression remains to be elucidated. Although it is known that many miRNAs are involved in regulation of malignant phenotypes glioma, role miR-4476 not reported yet. In present study, we identify as an upregulated microRNA, which promotes cell proliferation, migration, invasion glioma. Further mechanistic analyses indicate adenomatous polyposis coli (APC),...
Abstract The homeobox protein cut-like 1 (CUX1) comprises three isoforms and has been shown to be involved in the development of various types malignancies. However, expression role CUX1 glioma remain unclear. Herein, we first identified that P75CUX1 isoform exhibited consistent among with specifically designed antibodies identify all isoforms. Moreover, a significantly higher was found compared non-tumor brain (NB) tissues, analyzed western blot immunohistochemistry, level positively...
Background: Gliomas are highly lethal brain tumors. Despite multimodality therapy with surgery, radiotherapy, chemotherapy, and immunotherapy, glioma prognosis remains poor. Ferroptosis is a crucial tumor suppressor mechanism that has been proven to be effective in anticancer therapy. However, the implications of ferroptosis on clinical prognosis, immune checkpoint inhibitor (ICI) for patients still need elucidation. Methods: Consensus clustering revealed two distinct ferroptosis-related...
Eukaryotic translation elongation factor 1 δ (EEF1D), a subunit of the complex proteins, mediates process protein synthesis. Besides this canonical role, EEF1D was found overexpressed in many tumors, like hepatocarcinomas and medulloblastomas. In present study, we demonstrated for first time that may interact with other putative proteins to regulate cell proliferation, migration, invasion through PI3K/Akt EMT pathways glioma. Furthermore, knockdown could reduce proliferation impaired...
Glioma is the most common primary tumor of central nervous system. We previously confirmed that zinc finger E-box binding homeobox (ZEB) 2 promotes malignant progression glioma, while microRNA-637 (miR-637) associated with favorable prognosis in glioma. This study aimed to investigate potential interaction between ZEB2 and miR-637 its downstream signaling pathway The results revealed could directly bind elements promoter promote cell proliferation, migration, invasion via downregulation....
The dysregulation and essential role of WNTs in glioma have been widely implicated. However, there is a paucity literature on the expression status all 19 glioma. Our study was aimed to evaluate prognostic values glioma.mRNA clinical data were retrieved from Cancer Genome Atlas (TCGA) database, Chinese Glioma (CGGA), GTEx ONCOMINE databases. 50 frequent neighbor genes WNT5A WNT10B shown with PPI network, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses.We found that mRNA...