A5101536449- MicroRNA in disease regulation
- Aluminum toxicity and tolerance in plants and animals
- Circular RNAs in diseases
- Malaria Research and Control
- Quantum chaos and dynamical systems
- Heavy Metal Exposure and Toxicity
- Ferroptosis and cancer prognosis
- Evolution and Genetic Dynamics
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Extracellular vesicles in disease
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Advanced Differential Equations and Dynamical Systems
- Mathematical and Theoretical Epidemiology and Ecology Models
- RNA modifications and cancer
- HIV/AIDS drug development and treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immune responses and vaccinations
- Vector-borne infectious diseases
- Biosensors and Analytical Detection
- Toxin Mechanisms and Immunotoxins
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
- Zoonotic diseases and public health
Affiliated Hospital of Youjiang Medical University for Nationalities
2015-2024
Shandong Agricultural University
2023
Chiayi Chang Gung Memorial Hospital
2020
Youjiang Medical College for Nationalities
2019
China Agricultural University
2014
Research Center of Neurology
2011
National Yang Ming University Hospital
2010
National Yang Ming Chiao Tung University
2010
Academia Sinica
2010
Shandong University of Science and Technology
2004-2006
Brains are vulnerable to ischemic/hypoxic damage, which directly caused by stroke, hypoxic-ischemic encephalopathy and other cerebral diseases. Currently, therapeutic strategies against ischemia hypoxia extremely limited. Recent studies have indicated that stem cell-derived exosomes play a neuroprotective role in brain injury. However, the treatment mechanism remains unclear. In this study, we cultured neural cells (NSCs) vitro successfully. Exosomes isolated from NSCs (NSCs-Ex) inhibited...
Microscopic examination of thick and thin blood smears stained with Giemsa dye is considered the primary diagnostic tool for confirmation management suspected clinical malaria. However, detecting gametocytes relatively insensitive, particularly in asymptomatic individuals low-density Plasmodium infections. To complement existing methods, a rapid ultrasensitive point-of-care testing (POCT) platform malaria detection urgently needed necessary. A based on recombinase polymerase amplification...
Embryonic mortality during the implantation period strongly affects litter size in pigs. To analyze differentially expressed genes (DEGs) endometrium and further to identify candidate for size, tissues of endometrial attachment sites intersites were collected from nine pregnant sows on Days 13, 18, 24 pregnancy. Endometrium tissue was also another three nonpregnant sows. Samples hybridized porcine Agilent GeneChip microarray. The analysis gene expression patterns over revealed 858 DEGs at...
Glioblastoma has been identified as the most common and aggressive primary brain tumor in adults. Recently, it found that cisplatin (DDP) treatment is a chemotherapeutic method for GBM patients. circ_PTN (ID number: hsa_circ_0003949) newly circular (circRNA) which proved to be highly expressed cells, while its role remains unclear. Therefore, our study focused on investigating of DDP resistance cells. The expression DDP-sensitive DDP-resistant cells was detected assay. Functional experiments...
Rationale: The potential benefits of statins for the prevention exacerbations in patients with COPD remains controversial. No previous studies have investigated impact on clinical outcomes frequent exacerbations. Objective: This study aimed to evaluate association between use and risk subsequent hospitalized exacerbators. Materials Methods: We conducted a population-based cohort using Taiwan National Health Insurance Research Database. 139,223 first exacerbation 2004 2012 were analyzed....
Cerebral ischemia‑reperfusion (I/R) can result in severe brain injury, for which there are no optimal treatment options. I/R is often accompanied by increased autophagy. Beclin‑1, a central player autophagy, has been extensively studied I/R; however, to date, at least the best of our knowledge, definitive descriptions its specific role. Thus, aim present study was explore regulatory role played Beclin‑1 I/R. In vivo experiments were performed using an animal model with male Sprague‑Dawley...
Estradiol regulates spermatogenesis partly via estrogen receptor-alpha (ESRα). This study aimed to analyze the associations of serum estradiol level, ESRα and gene polymorphisms with sperm quality.This retrospective included infertile men attending Reproductive Center, Affiliated Hospital Youjiang Medical University for Nationalities, a control group without history fertility (October, 2016 March, 2017). Data regarding quality, levels ESRα, rs2234693C/T genotype were extracted from medical...
Purpose: Although the polymorphisms of erythrocyte complement receptor type 1 (CR1) in patients with malaria have been extensively studied, a question whether CR1 are associated severe remains controversial.Furthermore, no study has examined association Chinese population.Therefore, we investigated relationship gene polymorphism and population.Materials Methods: We analyzed rs2274567 G/A, rs4844600 rs2296160 C/T 509 503 controls, using Taqman genotyping assay PCR-direct sequencing.Results:...
Abstract Background Malaria remains a serious public health problem worldwide, particularly in Africa. Resistance to antimalarial drugs is an essential issue for malaria control and elimination. Currently, polymerase chain reaction (PCR) combined with Sanger sequencing regarded as the gold standard mutation detection. However, this method fails meet requirements of point-of-care testing (POCT) because its time-consuming, expensive instruments professional dependence. To support strategy, we...
The study is to validate the transmission route of rabbit meridian and organizational structure in cellular level. water solution Na <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> H <sup xmlns:xlink="http://www.w3.org/1999/xlink">32</sup> PO xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> (18.5MBq/0.25ml) was injected into "waiguan", "neiguan", "yang gu", "taixi" acupoint according human meridian. tissue were detected with P whole...
The aim of this study is to compare the spectrum and frequency GJB2, SLC26A4, GJB3, MT-RNR1 mutations in 4 different areas China.A total 509 patients from Linyi, Xinxiang, Yichang, Baise were enrolled study. Twenty most common mutation sites analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Patients Yichang (in central China; 22.50%) Linyi eastern 23.55%) carried a greater proportion 5 GJB2 compared with other 2 surveyed, namely Xinxiang North China...
In this paper, we study a predator-prey model with Beddington-DeAngelis functional response and two delays. model, selective harvesting of predator species is discussed delays describe the time that juveniles take to mature. We have analyzed effects delay on dynamics. First, existence, uniqueness positive equilibrium are discussed. Then, by analyzing associated characteristic equation, stability some sufficient conditions for existence Hopf bifurcation given. Finally, theoretical prediction...
Abstract Purpose CLIC family members act as tumor suppressors or oncogenes in multiple cancer processes. However, the of genes bladder is currently not well characterized. Methods 375 samples containing RNASeq and clinical data were downloaded from TCGA database. The present study aimed to analyze role using bioinformatics analysis. Quantitative real-time PCR Western blotting performed quantify gene protein expression, respectively. impact on characteristics TME was also analyzed. Results...