A5061834808- Orthopaedic implants and arthroplasty
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Pharmacological Effects of Medicinal Plants
- Pregnancy-related medical research
- Extracellular vesicles in disease
- HIV, Drug Use, Sexual Risk
- Tendon Structure and Treatment
- Circular RNAs in diseases
- Ionosphere and magnetosphere dynamics
- Magnetic confinement fusion research
- Musculoskeletal pain and rehabilitation
- Selenium in Biological Systems
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Sex work and related issues
- Bone Tissue Engineering Materials
- Bone health and treatments
- Congenital Heart Disease Studies
- Spine and Intervertebral Disc Pathology
- Cytomegalovirus and herpesvirus research
- Tissue Engineering and Regenerative Medicine
- Frailty in Older Adults
- Wnt/β-catenin signaling in development and cancer
Guangxi University
2011-2022
Sichuan University
2022
Soochow University
2017-2021
Wuxi Ninth People's Hospital
2021
Guangxi Medical University
2018-2021
Cardiovascular Institute of the South
2020
Stanford University
2020
Huazhong University of Science and Technology
2013-2020
Union Hospital
2020
First Affiliated Hospital of Soochow University
2017-2019
Bone mass loss around prostheses is a major cause of implant failure, especially in postmenopausal osteoporosis patients. In osteoporosis, excess oxidative stress largely contributed abnormal bone remodeling. Melatonin, which synthesized from the pineal gland, promotes osteoblast differentiation and formation has effectively been used to combat stress. Thus, we determined if melatonin can inhibit promote osteogenesis improve osteoporosis. this study, observed that received at 50 mg/kg body...
Brains are vulnerable to ischemic/hypoxic damage, which directly caused by stroke, hypoxic-ischemic encephalopathy and other cerebral diseases. Currently, therapeutic strategies against ischemia hypoxia extremely limited. Recent studies have indicated that stem cell-derived exosomes play a neuroprotective role in brain injury. However, the treatment mechanism remains unclear. In this study, we cultured neural cells (NSCs) vitro successfully. Exosomes isolated from NSCs (NSCs-Ex) inhibited...
Abstract Intervertebral disc degeneration (IVDD) is one of the key predisposing factors for low back pain. Although exact mechanism remains unclear, inflammatory response and nucleus pulposus (NP) apoptosis are known to play important roles in this process. Prolactin protects against inflammation-associated chondrocyte arthritis. Based on prior studies, we hypothesized that prolactin might have therapeutic effects IVDD by inhibiting degenerative human NP cells. An experimental model was...
Intervertebral disc (IVD) degeneration (IDD) is a major cause of low back pain. The pathogenesis IDD associated with the disturbance reactive oxygen species (ROS) equilibrium, inflammation, and matrix loss. Aspirin nonsteroidal anti-inflammatory drug that effectively inhibits inflammation oxidative stress has been widely used for treatment Therefore, we hypothesize aspirin reverses process via antioxidative effects on AMPK signaling pathway. In vitro , diminished cellular free radicals (ROS,...
It has been hypothesized that adult hematopoietic stem cells (HSCs) need to remain quiescent retain their long-term self-renewal activity and multipotency. However, it is still unclear how lack of quiescence detrimental HSC. We identified the mTOR pathway key HSCs quiescence. overactivation caused increased mitochondrial biogenesis accumulation much higher level reactive oxygen species (ROS). Removal ROS rescued HSC defects associated with hyperactivated mTOR. propose susceptibility as...
miRNAs are small, signal-strand, non-coding RNAs that function in post-transcriptional regulation. We analysed the vivo effect of miR-106b (miR-106b-5p) on inflammatory bone loss CIA mice.CIA mice developed by injecting DAB/1 with bovine type II collagen containing Freund's adjuvant and then is examined. On day 22, were given lentiviral negative control, lentiviral-mediated mimics or inhibitor via orbital injection a weekly basis. Morphological changes ankle joints assessed micro-CT...
ABSTRACT Cannabinoid receptor 2 (CB2) has been implicated as an important clinical regulator of inflammation and malignant osteolysis. Here, we observed that CB2 expression was markedly higher in the collagen-induced arthritis (CIA) mice synovium bone tissues than noninflamed tissues. The selective agonist (JWH133) but not antagonist (SR144528) suppressed CIA without toxic effects, demonstrated by decreased synovial hyperplasia, inflammatory responses, cartilage damage, periarticular...
Objectives: Pneumonia is a common perioperative complication in geriatric patients with hip fractures. This study aimed to analyze demographic characteristics, mortality rates, postoperative outcomes, and comorbidities, identify risk factors for mortality, develop nomogram predicting the prognosis of these patients. Methods: Data on hospitalized arthroplasty fractures from 2020 2023 at three hospitals were retrospectively analyzed. Patients divided into P group (patients complicated...
Abstract Wear debris-induced osteogenic inhibition and bone destruction are critical in the initiation of peri-prosthetic osteolysis. However, molecular mechanism underlying this phenomenon is poorly understood. In study, we analyzed involvement GSK-3 β/β -catenin signal pathway, which important for formation pathological condition. We established a titanium (Ti) particle-stressed murine MC3T3-E1 cell culture system calvariae osteolysis model to test hypothesis that Ti particle-induced...
Rationale: Peri-prosthetic osteolysis (PPO) is mainly induced by wear particles and represents the leading cause of implant failure revision surgery. Previous studies have identified mitigation particle-induced inflammation bone resorption as main approaches to treat PPO. Recently, reduction formation around prosthesis was a major factor in development Acetyl-11-keto-β-boswellic acid (AKBA), derivative frankincense, has been shown play potential role metabolism. However, whether AKBA...
Burgeoning applications of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in disease modeling, regenerative medicine, and drug screening have broadened the usage hiPSC-CMs entailed their long-term storage. Cryopreservation is most common approach to store hiPSC-CMs. However, effects cryopreservation recovery on remain poorly understood. Here, we characterized transcriptome, electro-mechanical function, response fresh without recovered from cryopreservation. We found...
Abstract We propose that in the microenvironment of inflammatory tissues, including tumours, extracellular proteinases can modulate cell signalling part by regulating proteinase-activated receptors (PARs). have been exploring this mechanism a variety inflammation and tumour-related settings include tumour-derived cultured cells from prostate bladder cancer, as well immune are involved pathology diseases multiple sclerosis. Our work showed proteinase via PARs affects cancer-derived tumour...
Abstract Background Epidemiological and clinical features of patients with COVID‐19 have been reported, but none them focused on medical staff, few predictors the duration viral shedding reported. It is urgent to help healthcare workers prevent recover quickly from coronavirus disease 2019 (COVID‐19). Methods We enrolled 140 in Wuhan. Epidemiological, demographic, clinical, laboratory, radiological treatment outcome data were collected, explored through multivariable linear regression...
Wear-debris-induced osteolysis and subsequent aseptic loosening of the prosthesis are main reasons for failed arthroplasty. Inhibition wear-debris-induced osteoclastogenesis is thus a promising method to prolong lifetime prostheses. In this work, mussel-derived peptide, capped with an integrin-targeting RGD tripeptide titanium (Ti)-affinity tetrapeptide catechol groups at each end biomimetically designed. The peptide can interfere integrin αv β3 affect cytoskeletal organization functions...
Orthodontic force-induced osteogenic differentiation and bone formation at tension sites play a critical role in orthodontic tooth movement. However, the molecular mechanism underlying this phenomenon is poorly understood. In current study, we investigated involvement of GSK-3β/β-catenin signaling pathway, which for during We established rat movement model to test hypothesis that force may stimulate site moved promote rate via regulation pathway. Our results showed continued mechanical...
Abstract Excessive osteoclast recruitment and activation is the chief cause of periprosthetic osteolysis subsequent aseptic loosening, so blocking may be useful for protecting against osteoclastic bone resorption. We studied effect aspirin on titanium (Ti)‐particle‐induced in vivo vitro using male C57BL/6J mice randomized to sham (sham surgery), Ti (Ti particles), low‐dose (Ti/5 mg·kg −1 ·d aspirin), high‐dose (Ti/30 aspirin). After 2 weeks, a three‐dimensional reconstruction evaluation...
Abstract Background Adipose-derived mesenchymal stem cells (AD-MSCs) are a type of cell that is abundant and widely used. The molecular characteristics AD-MSCs from different passages donors ages have not been well elucidated. Methods Six kinds ((E1, E2, E3, Y1, Y2, Y3) with E denoting derived an elderly patient, Y young 1, 2, 3 representing 3, 6, 10) were obtained human abdominal adipose tissue. We the protein expression profile, mRNA lncRNA methylation profile each kind AD-MSC by...