A5102860974- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Plant Toxicity and Pharmacological Properties
First Affiliated Hospital of Soochow University
2019-2021
Soochow University
2019-2021
Intervertebral disc (IVD) degeneration (IDD) is a major cause of low back pain. The pathogenesis IDD associated with the disturbance reactive oxygen species (ROS) equilibrium, inflammation, and matrix loss. Aspirin nonsteroidal anti-inflammatory drug that effectively inhibits inflammation oxidative stress has been widely used for treatment Therefore, we hypothesize aspirin reverses process via antioxidative effects on AMPK signaling pathway. In vitro , diminished cellular free radicals (ROS,...
Abstract Background Nucleus pulposus cell (NPC) degeneration is widely accepted as one of the major causes intervertebral disc (IVD) (IVDD). The pathogenesis IVDD complex and consists inflammation, oxidative stress, loss extracellular matrix (ECM). Cannabinoid type 2 receptor (CB2) has been shown to be involved in pathological mechanism a variety diseases due its anti-inflammatory effects antioxidative stress capacity. Method In Vitro, H O was used induce nucleus cells, mRNA protein...