A5100462044- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Chemokine receptors and signaling
- Brain Metastases and Treatment
- RNA Interference and Gene Delivery
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- interferon and immune responses
- DNA and Nucleic Acid Chemistry
- Thin-Film Transistor Technologies
- ZnO doping and properties
- Biofuel production and bioconversion
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- Cancer therapeutics and mechanisms
- Autophagy in Disease and Therapy
- CRISPR and Genetic Engineering
- Sperm and Testicular Function
Chinese Academy of Sciences
2024-2025
Soochow University
2015-2025
First Affiliated Hospital of Soochow University
2015-2025
Institute of Microbiology
2024-2025
Jiujiang University
2023-2025
Changzhou No.2 People's Hospital
2023-2024
Nanjing Medical University
2019-2024
Sun Yat-sen University
2014-2024
Czech Academy of Sciences, Institute of Microbiology
2024
University of Chicago
2020-2024
Objective Our goals were to evaluate the antitumour efficacy of Lactobacillus rhamnosus GG (LGG) in combination with immune checkpoint blockade (ICB) immunotherapies on tumour growth and investigate underlying mechanisms. Design We used murine models colorectal cancer melanoma whether oral administration LGG improves ICB therapies. performed whole genome shotgun metagenome sequencing intestinal contents RNA dendritic cells (DCs). In a series vitro vivo experiments, we further defined...
Recently, sensitive and selective detection of exosomal microRNAs (miRNAs) has been garnering significant attention, because it is related to many complex diseases, including cancer. Herein, we report a ratiometric fluorescent bioprobe based on DNA-labeled carbon dots (DNA-CDs) 5,7-dinitro-2-sulfo-acridone (DSA) coupling with the target-catalyzing signal amplification for miRNA-21. There was high fluorescence resonance energy transfer (FRET) efficiency between (CDs) DSA when assembled....
The treatment of diabetic wounds faces enormous challenges due to complex wound environments, such as infected biofilms, excessive inflammation, and impaired angiogenesis. critical role the microenvironment in chronic has not been addressed for therapeutic development. Herein, we develop a microneedle (MN) bandage functionalized with dopamine-coated hybrid nanoparticles containing selenium chlorin e6 (SeC@PA), which is capable dual-directional regulation reactive species (RS) generation,...
The majority of cancer patients receive radiotherapy during the course treatment, delivered with curative intent for local tumor control or as part a multimodality regimen aimed at eliminating distant metastasis. A major focus research has been DNA damage; however, in past two decades, emphasis shifted to important role immune system plays radiotherapy-induced anti-tumor effects. Radiotherapy reprograms microenvironment, triggering and RNA sensing cascades that activate innate immunity...
A novel high‐performance flexible gel polymer electrolyte (FGPE) for supercapacitors is prepared by a freeze‐drying method. In the presence of 1‐butyl‐3‐methylimidazolium chloride (BMIMCl) ionic liquid, Li 2 SO 4 can easily be added into poly(vinyl alcohol) (PVA) aqueous solution over large concentration range. The resultant FGPE demonstrates considerably high conductivity (37 mS cm −1 ) and fracture strain at 100% elongation optimal weight ratio PVA:BMIMCl:Li = 1:3:2.2. supercapacitor...
The antitumor effects of ionizing radiation (IR) are mediated in part through activation innate and adaptive immunity. Here we report that gut microbiota influences tumor control following IR. Vancomycin decreased the abundance butyrate-producing bacteria enhanced responses to Oral administration Lachnospiraceae, a family vancomycin-sensitive bacteria, was associated with increased systemic intratumoral butyric acid levels impaired efficacy IR germ-free (GF) mice. Local butyrate inhibited...
Tumor-induced CD45-Ter119+CD71+ erythroid progenitor cells, termed "Ter cells," promote tumor progression by secreting artemin (ARTN), a neurotrophic peptide that activates REarranged during Transfection (RET) signaling. We demonstrate both local ionizing radiation (IR) and anti-programmed death ligand 1 (PD-L1) treatment decreased tumor-induced Ter cell abundance in the mouse spleen ARTN secretion outside irradiation field an interferon- CD8+ T cell-dependent manner. Recombinant...
Abstract Purpose: Radiotherapy (RT) is a widely employed anticancer treatment. Emerging evidence suggests that RT can elicit both tumor-inhibiting and tumor-promoting immune effects. The purpose of this study to investigate suppressive factors radiotherapy. Experimental Design: We used heterologous two-tumor model in which adaptive concomitant immunity was eliminated. Results: Through analysis PD-L1 expression myeloid-derived suppressor cells (MDSC) frequencies using patient peripheral blood...
Preclinical and clinical observations indicate that the probiotic Lactobacillus rhamnosus GG (LGG) can modulate colonic inflammation. However, underlying mechanisms have not been explored in depth. Here, we demonstrate oral administration of live LGG alleviated inflammatory colitis by increasing IL-10 expression intestinal Ly6C+ monocytes. Mechanistically, induced production via stimulator IFN genes (STING)/TBK1/NF-κB (RELA) signaling pathway monocytes, enhancing their immune-suppressive...
To improve their therapeutic index, designed nanocarriers should preferentially accumulate in tumor tissues and then rapidly enter cells to release the encapsulated drugs a triggered manner. In this article, new kind of smart pH- reduction-dual-responsive drug delivery system based on folate-PEG-coated polymeric lipid vesicles (FPPLVs) formed from amphiphilic dextran derivatives was prepared successfully. PEG chains with pH-sensitive hydrazone bonds, stearyl alcohol (SA) reduction-sensitive...