A5010501938- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- MicroRNA in disease regulation
- Eosinophilic Disorders and Syndromes
- Cancer-related molecular mechanisms research
- Microscopic Colitis
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Asthma and respiratory diseases
- RNA modifications and cancer
- Extracellular vesicles in disease
- DNA Repair Mechanisms
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Lysosomal Storage Disorders Research
- Genetic factors in colorectal cancer
- Diagnosis and treatment of tuberculosis
- Autoimmune and Inflammatory Disorders Research
- RNA Research and Splicing
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nuclear Structure and Function
First Affiliated Hospital of Xi'an Jiaotong University
2024
University of Chicago
2017-2023
Indiana University Bloomington
2020
Indiana University Health
2020
University of Toronto
2015
Canada Research Chairs
2015
Cincinnati Children's Hospital Medical Center
2005-2014
University of Cincinnati
2009-2014
University of Cincinnati Medical Center
2005-2006
Abstract Allergic airway inflammation is characterized by marked in situ changes gene and protein expression, yet the role of microRNAs (miRNAs), a new family key mRNA regulatory molecules, this process has not been reported. Using highly sensitive microarray-based approach, we identified 21 miRNAs with differential expression between doxycycline-induced lung-specific IL-13 transgenic mice (with allergic inflammation) control mice. In particular, observed overexpression miR-21...
An altered balance between Th1 and Th2 cytokines is responsible for a variety of immunoinflammatory disorders such as asthma, yet the role posttranscriptional mechanisms, those mediated by microRNAs (miRs), in adjusting relative magnitude Th cytokine expression have been largely unexplored. In this study, we show that miR-21 has central setting responses to Ags. Targeted ablation mice led reduced lung eosinophilia after allergen challenge, with broadly reprogrammed immunoactivation...
Background and aimsMouse models of colitis have been used to study the pathogenesis inflammatory bowel disease (IBD) for pre-clinical development therapeutic agents. Various epigenetic pathways shown play important regulatory roles in IBD. Reversible N6-methyladenosine (m6A) methylation represents a new layer post-transcriptional gene regulation that affects variety biological processes. We aim how deletion critical component m6A writer complex, METTL14, T cells colitis.MethodsConditional...
DNA double-strand breaks (DSBs) are often targeted to nuclear pore complexes (NPCs) for repair. How targeting is achieved and the repair pathways involved in this process remain unclear. Here, we show that kinesin-14 motor protein complex (Cik1-Kar3) cooperates with chromatin remodellers mediate interactions between subtelomeric DSBs Nup84 ensure cell survival via break-induced replication (BIR), an error-prone process. Insertion of a zip code near DSB site artificially targets it NPCs...
Recently, microRNAs have been shown to be involved in hematopoietic cell development, but their role eosinophilopoiesis has not yet described. In this article, we show that miR-223 is upregulated during eosinophil differentiation an ex vivo bone marrow-derived culture system. Targeted ablation of leads increased proliferation progenitors. We found upregulation a target gene, IGF1R, the progenitor cultures derived from miR-223(-/-) mice compared with miR-223(+/+) littermate controls. The...
MiR-21 is one of the most up-regulated miRNAs in multiple allergic diseases associated with eosinophilia and has been shown to positively correlate eosinophil levels. Herein, we show that miR-21 during IL-5-driven differentiation from progenitor cells vitro. Targeted ablation leads reduced cell growth. Furthermore, miR-21(-/-) have increased apoptosis as indicated by levels annexin V positivity compared miR-21(+/+) cells. Indeed, mice blood vivo colony forming unit capacity bone marrow....
INTRODUCTION: Ineffective esophageal motility (IEM) is a minor motor disorder with potential reflux implications. Contraction reserve, manifested as augmentation of body contraction after multiple rapid swallows (MRS), may affect acid exposure time (AET) in IEM. METHODS: Esophageal high-resolution manometry (HRM) and ambulatory monitoring studies were reviewed over 2 years to identify patients normal HRM, IEM (≥50% ineffective swallows), absent contractility (100% failed swallows). Single...
The aim of this study was to investigate the outcome in 556 patients with locally advanced nasopharyngeal carcinomas treated by radiation therapy alone. We observed stage T3-4 and N0-3 carcinoma who were conventional radiotherapy alone between January December 1999. total dose delivered nasopharynx 66-80 Gy over 6.5-8 weeks neck lymph nodes 60-70 6-7 weeks. 5-year actuarial overall survival rate (OS) reached 66.41%. OS higher among T3 than T4 (69.12% vs 58.96%, p = 0.0359). Among N0, N1, N2...
Eosinophils are multifunctional effector cells implicated in the pathogenesis of a variety diseases including asthma, eosinophil gastrointestinal disorders and helminth infection. Mouse bone marrow derived progenitor can be differentiated into eosinophils following IL-5 exposure. These fully at end 14 day culture based on morphology expression molecular markers.