A5101996866- Retinal Development and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Musculoskeletal pain and rehabilitation
- Diet, Metabolism, and Disease
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Connexins and lens biology
- Cellular transport and secretion
- Liver Disease Diagnosis and Treatment
- Complementary and Alternative Medicine Studies
- Cardiovascular Effects of Exercise
- Pancreatic function and diabetes
- Eosinophilic Disorders and Syndromes
- Cardiovascular and exercise physiology
- Health and Wellbeing Research
- Diabetes Management and Education
- Regulation of Appetite and Obesity
- Calcium signaling and nucleotide metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Reproductive Biology and Fertility
- Metabolism, Diabetes, and Cancer
CHA University
2012-2023
Daejeon University
2020
The University of Sydney
2016-2017
Ewha Womans University
2015-2016
Cincinnati Children's Hospital Medical Center
2011-2013
University of Cincinnati
2011-2013
Kyung Hee University
2010-2011
Catholic University of Korea
2003-2008
Nuffield Orthopaedic Centre
1998
An altered balance between Th1 and Th2 cytokines is responsible for a variety of immunoinflammatory disorders such as asthma, yet the role posttranscriptional mechanisms, those mediated by microRNAs (miRs), in adjusting relative magnitude Th cytokine expression have been largely unexplored. In this study, we show that miR-21 has central setting responses to Ags. Targeted ablation mice led reduced lung eosinophilia after allergen challenge, with broadly reprogrammed immunoactivation...
Cisplatin is a first-line chemotherapeutic agent for ovarian cancer that acts by promoting DNA cross links and adduct. However drug resistance considerable side effects including reproductive toxicity remain significant challenge. PTEN well known as tumor suppressor function which plays fundamental role in the regulation of cell cycle, apoptosis development cancer. At same time has been revealed to be critically important maintenance primordial follicle pool. In this study, we investigated...
Ghrelin is an endogenous ligand for GH secretagogue receptor type 1a (GHSR1a), and produced released mainly from the stomach. It has been recently demonstrated that ghrelin can function as a neuroprotective factor by inhibiting apoptotic pathways. Kainic acid (KA), excitatory amino l -glutamate analog, causes neuronal death in hippocampus; previous studies suggest activated microglia astrocytes actively participate pathogenesis of KA-induced hippocampal neurodegeneration. However, it unclear...
Recently, microRNAs have been shown to be involved in hematopoietic cell development, but their role eosinophilopoiesis has not yet described. In this article, we show that miR-223 is upregulated during eosinophil differentiation an ex vivo bone marrow-derived culture system. Targeted ablation of leads increased proliferation progenitors. We found upregulation a target gene, IGF1R, the progenitor cultures derived from miR-223(-/-) mice compared with miR-223(+/+) littermate controls. The...
MiR-21 is one of the most up-regulated miRNAs in multiple allergic diseases associated with eosinophilia and has been shown to positively correlate eosinophil levels. Herein, we show that miR-21 during IL-5-driven differentiation from progenitor cells vitro. Targeted ablation leads reduced cell growth. Furthermore, miR-21(-/-) have increased apoptosis as indicated by levels annexin V positivity compared miR-21(+/+) cells. Indeed, mice blood vivo colony forming unit capacity bone marrow....
Turanose is a sucrose isomer naturally existing in honey and promising functional sweetener due to its low glycemic response. In this study, the extrinsic fructose effect on turanose productivity was examined Neisseria amylosucrase reaction. produced, by increasing amount of as reaction modulator, with high concentration substrate, which resulted 73.7% production yield. physiological functionality test, lipid accumulation 3T3-L1 preadipocytes presence amounts pure glucose attenuated...
Deciphering the molecular basis of neuronal cell death is a central issue in etiology neurodegenerative diseases, such as Parkinson's and Alzheimer's. Dysregulation p53 levels has been implicated apoptosis. The role histone deacetylase 3 (HDAC3) suppressing p53-dependent apoptosis recently emphasized; however, modulation function by HDAC3 remains unclear. Here we show that PTEN-induced putative kinase 1 (PINK1), which linked to autosomal recessive early-onset familial disease, phosphorylates...
Growth hormone (GH)/insulin-like growth factor-I deficiencies are known to cause alterations in brain development resulting impairment of cognitive function. In order investigate the behavioral phenotype GH-deficient spontaneous dwarf rats (SDRs), we examined behavior SDRs Morris water maze and Y-maze tasks. The showed severe deficits spatial learning memory compared normal rats. possibility that is associated with alteration neurotransmitter systems was histologically following completion...
Type 2 diabetes is a major public health concern worldwide. Xylobiose (XB) consists of two molecules d-xylose and disaccharide in xylooligosaccharides that are used as prebiotics. We hypothesized XB could regulate diabetes-related metabolic genetic changes via microRNA expression db/db mice. For six weeks, C57BL/KsJ-db/db mice received 5% part the total sucrose content their diet. supplementation improved glucose tolerance with reduced levels OGTT AUC, fasting blood glucose, HbA1c, insulin,...
Primordial follicles are formed prenatally in mammalian ovaries, and at birth they fated to be activated primary follicles, dormant, or die. During the early stage of folliclulogenesis, oocyte undergoes dynamic alterations expression numerous genes, which regulated by transcription factors. Several germ-cell specific transcriptional regulators critical for formation maintenance follicles. These include: Figla, Lhx8, Nobox, Sohlh1, Sohlh2. A subset these is mutated women with ovarian...
DNA demethylation has been primarily studied in the context of development biology, cell fate, and cancer, with less attention on inflammation. In this article, we investigate association between methylation production chemoattractant cytokine eotaxin-3 tissue patients allergic disease. Regions human promoter were found to be hypomethylated primary epithelial cells obtained from compared normal control tissue. The a specific CpG site (designated 2), which is juxtaposed key cAMP-responsive...
ABSTRACT Clinical and experimental studies demonstrate that injured anterior cruciate ligaments (ACL) do not usually heal autografts used to repair the ACL rapidly weaken in early period take a long time regain strength. The aim of this study was develop an vitro culture system which environmental biochemical factors influencing proliferation matrix synthesis cells derived from human can be studied. Primary cultures were obtained by outgrowth explants normal at knee replacement for...
Abstract Disabled 1 (Dab1) is an adapter molecule in a signaling pathway, stimulated by Reelin, which controls cell positioning the developing brain. It has been localized to AII amacrine cells mouse and guinea pig retinas. This study was conducted identify whether Dab1 commonly retinas of other mammals. We investigated Dab1‐labeled human, rat, rabbit, cat detail immunocytochemistry with antisera against Dab1. immunoreactivity found certain populations cells, lobular appendages outer half...