A5102027537- Random lasers and scattering media
- Histone Deacetylase Inhibitors Research
- Cell Image Analysis Techniques
- Advanced Optical Imaging Technologies
- IL-33, ST2, and ILC Pathways
- Eosinophilic Disorders and Syndromes
- Eosinophilic Esophagitis
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Nonmelanoma Skin Cancer Studies
- RNA Interference and Gene Delivery
- Medical Image Segmentation Techniques
- interferon and immune responses
- Hippo pathway signaling and YAP/TAZ
- Image and Video Quality Assessment
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- PARP inhibition in cancer therapy
- Macrophage Migration Inhibitory Factor
- Cancer Cells and Metastasis
- Phytoestrogen effects and research
- Synthesis and biological activity
- Inflammation biomarkers and pathways
- Aquaculture disease management and microbiota
- Extracellular vesicles in disease
National Kaohsiung Marine University
2025
Xi'an Jiaotong University
2022-2024
State Key Laboratory of Biotherapy
2024
Sichuan University
2019-2024
Bellevue Hospital Center
2024
UConn Health
2021-2023
Shenyang Medical College
2019-2022
Capital Medical University
2022
First Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Clinical applications of siRNA therapeutics have been limited by the immunogenicity and low efficiency delivery to target cells. Recently, evidence shown that exosomes, endogenous nano-vesicles, can deliver tumor tissues in mice. Here, reduce immunogenicity, we selected immature dendritic cells (DCs) produce exosomes. In addition, targeting was achieved engineering DCs express exosomal membrane protein (Lamp2b), fused av integrin-specific iRGD peptide (CRGDKGPDC). Next, targeted exosomes...
Abstract Synthetic lethality (SL), a genetic concept, has revolutionized the development of antitumor therapies by providing avenues to target previously “undruggable” targets with enhanced specificity for tumor cells over normal tissue. The principles SL have expanded beyond definitions encompass biological functions, including genome stability, cell cycle regulation, death mechanisms, cellular metabolism, cell–cell interactions, and microenvironment (TME). Tumor inactivated survival...
This study assessed the effects of Micro-bubble (MB; average size 36.50 μm) on physicochemical properties live shrimp (Litopenaeus vannamei) and cooked ones. also examined visual appearance, intestinal sludge's presence, microbial decontamination efficacy, meat's textural properties. In addition, sensory evaluation was conducted to appraise impact MB gustatory aromatic attributes shrimp. showed that treatment substantially better than traditional aeration (TA) in terms color, sludge...
Little is known about whether UVB can directly influence epigenetic regulatory pathways to induce cutaneous squamous cell carcinoma (CSCC). This study aimed identify epigenetic-regulated signalling through global methylation and gene expression profiling elucidate their function in CSCC development.Global DNA by reduced representation bisulfite sequencing (RRBS) genome-wide analysis RNA (RNA-seq) eight pairs of matched adjacent normal skin tissues were used investigate the potential...
In recent times, the medical science has developed by leaps and bounds, however, molecular mechanism of pediatric pneumonia is still unclear. Although prior researches have shown that methyltransferase-like 3 (METTL3) up-regulated in a variety inflammatory diseases, its role been rarely studied pneumonia, need to be defined elaborately.In this study, related METTL3 on inflammation cell apoptosis was investigated.Quantitative real-time polymerase chain reaction (qPCR) western blot assays were...
The outcome of Plasmodium yoelii 17XL-infected BALB/c and DBA/2 mice, ranging from death to spontaneous cure, respectively, depends largely on the establishment effective pro-inflammatory type 1 responses during early stages infection associates with CD4(+)CD25(+)Foxp3(+)regulatory T cells (Tregs). Here, effects Tregs were analysed P. 17XL in mice. In vivo depletion significantly reversed inhibited indicating that this cell population contributed suppression T-cell function malaria....
Abstract The histone acetyltransferase MOF (KAT8) is mainly involved in the acetylation of H4 at lysine 16 (H4K16) and some non‐histone proteins. expression level significantly reduced many cancers, however biological function its underlying mechanism are still elusive hepatocellular carcinoma (HCC). Estrogen receptor α (ERα) has been considered as a tumor suppressor HCC. Here, we demonstrated that HCC samples, positively correlated with ERα. interacts ERα, participates ERα K266, K268, K299,...
Arsenic trioxide (ATO) is a well-known inhibitor of cell proliferation. Preclinical and clinical studies showed that ATO has anti-myeloma effects. However, the underlying mechanism remains elusive. In this study, molecular mechanisms ATO-induced myeloma apoptosis were explored on four lines wild type or mutant p53 status also six primary cells. induced potent inhibition growth compared with controls. Further investigation down-regulated c-Myc phosphorylated (p)-Rb while up-regulating p53,...
Underwater imaging is a challenging task because of the effects scattering and absorption in water. Ghost (GI) has attracted increasing attention its simple structure, long range, achievability under weak light intensity. In an underwater environment, conventional limited by low sensitivity, resulting fuzzy images, while ghost can solve this problem. This study proposes laser based on Walsh speckle patterns. According to simulated experimental results, noise resistance sampling rate patterns...
This study aimed to investigate the effects of low-, medium-, and high-dose puerarin on cognitive impairment induced by 50% alcohol in mice revealed role autophagy-related signaling pathways (mTOR JNK pathways) this process.
Background: In the previous study, Puerariae Lobatae Radix (named Gegen in Chinese) water extract attenuated M3 receptor agonist carbachol-induced detrusor contraction after 3-week oral administration a hypertension-associated OAB (overactive bladder) model. This research aimed to investigate active ingredients from against OAB. Methods: Bioassay-guided fractionation was performed by using preparative HPLC for fast isolation of fractions followed screening their ex vivo activity through...
Introduction Cutaneous squamous cell carcinoma (CSCC) is the second-most common non-melanoma skin cancer after basal carcinoma, accounting for 20% of all cutaneous malignancies. CSCC originates from epidermal keratinocytes or adnexal structures such as eccrine glands pilosebaceous units.1 According to several studies focused on Caucasian populations in Europe, USA and Australia, about 15–35 per 100,000 individuals are diagnosed with each year, incidence expected increase by 2%–4% year.2 The...
Abstract Due to the complex physical processes found in underwater environments, such as absorption, scattering, and noise, it is challenging obtain high-quality images using conventional camera-based imaging techniques. Ghost possesses strong anti-interference capabilities can effectively environments. Here, we propose a ghost framework based on model of M 2 -ordered laser mode patterns apply Imaging. The simulation results show that Laser Mode Speckle Imaging reconstruct overall trapped...
Abstract Absorption, scattering, noise, and low-sensitivity detector lead to poor quality in conventional underwater imaging. In response, Ghost imaging (GI) has emerged as an effective anti-interference method based on the relationship between illumination speckle patterns a non-spatial-resolution detector. Conventional are distributed mathematical models such random, Hadamard, or Walsh models. this study, we apply novel physical model of M2 ordered laser modes GI. The mode pattern GI...