A5101491705- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Plant responses to water stress
- Genetic and phenotypic traits in livestock
- Molecular Biology Techniques and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Plant Stress Responses and Tolerance
- Animal Genetics and Reproduction
- Ferroptosis and cancer prognosis
- Soybean genetics and cultivation
- Aquaculture disease management and microbiota
- Phytochemicals and Antioxidant Activities
- Pancreatic and Hepatic Oncology Research
- Plant-based Medicinal Research
- Meat and Animal Product Quality
- Plant Disease Resistance and Genetics
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Plant Gene Expression Analysis
- Epigenetics and DNA Methylation
- Plant biochemistry and biosynthesis
- Plant Molecular Biology Research
- Cancer-related gene regulation
- Bioinformatics and Genomic Networks
- Simulation and Modeling Applications
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Nanjing Agricultural University
2010-2024
Soochow University
2024
Second Affiliated Hospital of Soochow University
2024
Shaanxi Institute of Zoology
2022-2023
Sweet Potato Research Institute
2020-2022
Inner Mongolia Agricultural University
2022
Guangxi Medical University
2014-2021
Affiliated Hospital of Nantong University
2019-2020
Chinese Academy of Agricultural Sciences
2020
As a natural compound extracted from variety of hot peppers, capsaicin has drawn increasing attention to its anti-cancer effects against multiple human cancers including breast cancer. FBI-1 is major proto-oncogene negatively regulating the transcription many tumor suppressor genes, and plays vital role in tumorigenesis progression. However, whether involved capsaicin-induced cancer suppression yet be ascertained. This study aimed investigate on proliferation apoptosis association with...
Enhanced disease susceptibility1 (EDS1) and phytoalexin deficient4 (PAD4) are well-known regulators of both basal resistance (R) protein-mediated plant defense. We identified two EDS1-like (GmEDS1a/GmEDS1b) proteins one PAD4-like (GmPAD4) protein that required for signaling in soybean (Glycine max). Consistent with their significant structural conservation to Arabidopsis (Arabidopsis thaliana) counterparts, constitutive expression GmEDS1 or GmPAD4 complemented the pathogen defects eds1 pad4...
Aldehyde dehydrogenases (ALDHs) represent a group of enzymes that detoxify aldehydes by facilitating their oxidation to carboxylic acids, and have been shown play roles in plant response abiotic stresses. However, the comprehensive analysis ALDH superfamily soybean (Glycine max) has limited. In present study, total 53 GmALDHs were identified soybean, grouped into 10 families according Gene Nomenclature Committee phylogenetic analysis. These groupings supported gene structures conserved...
In the pig production industry, artificial insemination (AI) plays an important role in enlarging beneficial impact of elite boars. Understanding genetic architecture and detecting markers associated with semen traits can help improving selection for such accelerate progress. this study, we utilized a weighted single-step genome-wide association study (wssGWAS) procedure to detect regions further candidate genes Duroc boar population. Overall, full pedigree consists 5284 pigs (12...
Meat quality is an important trait for pig-breeding programs aiming to meet consumers' demands. Geneticists must improve meat based on their understanding of the underlying genetic mechanisms. Previous studies showed that most meat-quality indicators were low-to-moderate heritability traits; therefore, improving using conventional techniques remains a challenge. Here, we performed genome-wide association study traits GeneSeek Porcine SNP50K BeadChip in 582 crossbred Duroc × (Landrace...
Soil alkalinity is a major abiotic constraint to crop productivity and quality. Wild soybean (Glycine soja) considered be more stress-tolerant than cultivated (G. max), has considerable genetic variation for increasing tolerance of soybean. In this study, we analyzed the transcriptome profile in roots an tolerant wild variety N24852 at 12 24 h after 90 mM NaHCO3 stress by RNA-sequencing. Compared with controls, total 449 differentially expressed genes (DEGs) were identified, including 95 140...
Abstract Drought tolerance is a complex trait in soybean that controlled by polygenetic quantitative loci (QTLs). In this study, wilting score, days-to-wilting, leaf relative water content, and conductivity were used to identify QTLs associated with drought recombinant inbred lines derived from cross between drought-sensitive variety, Lin, drought-tolerant Meng. A total of 33 drought-tolerance detected. Of these 17 major QTLs. addition, 15 novel The most predominant QTL was on chromosome 11....
It has been generally confirmed that zinc finger and BTB domain containing 7A (ZBTB7A) plays an important role in the occurrence progression of malignant tumours, but promotion or inhibition effect is related to tumour type. The mechanism between ZBTB7A breast cancer not well understood, so further research needed. In this study, we first investigated expression tissue samples clinical patients, MDA-MB-231, MCF-7 MCF-10A cells. Second, overexpressed cells silenced MDA-MB-231 using lentivirus...
The Inner Mongolia cashmere goat is an excellent local breed in China. According to the characteristics of wool quilts, can be divided into three types: a long-hair type (hair length >22 cm), short-hair ≤13 and intermediate >13 cm ≤22 cm). It found that hair has certain reference value for indirect selection other important economic traits cashmere. In order explore molecular mechanisms related regulatory genes different types, weighted gene coexpression network analysis (WGCNA) was carried...
Arsenic trioxide (ATO) is a well-known inhibitor of cell proliferation. Preclinical and clinical studies showed that ATO has anti-myeloma effects. However, the underlying mechanism remains elusive. In this study, molecular mechanisms ATO-induced myeloma apoptosis were explored on four lines wild type or mutant p53 status also six primary cells. induced potent inhibition growth compared with controls. Further investigation down-regulated c-Myc phosphorylated (p)-Rb while up-regulating p53,...
Pancreatic cancer is one of the most common malignant cancers worldwide. Currently, pathogenesis pancreatic remains unclear; thus, it necessary to explore its precise molecular mechanisms.To identify candidate genes involved in tumorigenesis and proliferation cancer, microarray datasets GSE32676, GSE15471 GSE71989 were downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed (DEGs) between ductal adenocarcinoma (PDAC) nonmalignant samples screened by GEO2R. The...
The high-affinity potassium transporters (HKT) mediate K+-Na+ homeostasis in plants. However, the function of enhancing low-potassium tolerance sweet potato [Ipomoea batatas (L.) Lam.] remains unrevealed. In this study, a novel HKT transporter homolog IbHKT-like gene was cloned from potato, which significantly induced by deficiency stress. overexpressing transgenic roots were obtained cultivar Xuzishu8 using an Agrobacterium rhizogenes-mediated root system vivo. Compared with CK, whose cells...
ATPase subunit 9 gene (Atp9) is an important functional in mitochondria, and closely related with energy supply. RNA editing of atp9 was associated male sterility plants. In this study, the soybeans cloned from asoybean cytoplasmic sterile line NJCMS2A its maintainer NJCMS2B.Sequence alignment performed, protein structures were analyzed compared between soybean NJCMS2B. The results show that fragments identicalsequences amplified genomic DNA NJCMS2B, while sequences different when they cDNAs...
The aim of the present study was to investigate role microRNA (miR)-29b in proliferation and migration bone marrow mesenchymal stem cells (BMSCs) rats with castration‑induced osteoporosis relevant mechanisms. gene expression profiling microarray technique utilized sequence BMSCs overexpressed miR‑29b. intersection potential targets genes downregulated sequencing were for GO enrichment analysis. Gene set analysis (GSEA) employed analyze effect miR‑29b on signaling pathways. Additionally,...
To elucidate the connection between flower coloration and expression of genes associated with anthocyanin biosynthesis, a gene encoding UDP-glucose: flavonoid 3-O-glucosyltransferase (UFGT) was isolated, last four in biosynthetic pathway during peach development determined. The nucleotide sequence UFGT (GenBank accession No. JX149550) is highly similar to its homologs other plants. Total content initially increased development, then decreased over time. Expression biosynthesis until...
Objective: To investigate the effect of esculin on proliferation triple negative breast cancer cells and its molecular mechanism. Methods: MDA-MB-231 were treated with 28, 56, 112, 225, 450 900 μmol/L for 24, 48 72 h, respectively, cell viability was detected by counting kit 8 (CCK-8) assay. In addition, 0, h. And then changes in morphology observed inverted microscope. The clone-forming ability colony formation mRNA expression levels FBI-1, p53 p21 using real-time fluorescence quantitative...
Gastric cancer (GC) is a leading cause of cancer‑associated mortality worldwide. Previous studies demonstrated that long noncoding RNAs (lncRNAs) may be dysregulated in GC and serve important roles progression. The present study aimed to investigate the role novel lncRNA stomach transcript 16 (STCAT16; Assembly Gene ID G038291) development progression GC. data suggested expression level STCAT16 was decreased tissues. identified associated with lymph node tumour metastasis stages....
The aim of the present study was to explore critical genes and molecular mechanisms in pancreatic cancer (PC) cells with glutamine. By analyzing microarray data GSE17632 from Gene Expression Omnibus database, DEGs between PC treated glutamine without were evaluated. Additionally, function enrichment analyses protein-protein interaction (PPI) network construction performed. Network module literature mining performed analyze cells. In total, 495 selected as control PC. These mainly enriched...