Utilizing the whole genomic variation of complex traits to predict yet-to-be observed phenotypes or unobserved genetic values via genome prediction (WGP) and infer underlying architecture wide association study (GWAS) is an interesting fast developing area in context human disease studies as well animal plant breeding. Though thousands significant loci for several species were detected GWAS past decade, they not used directly improve WGP due lack proper models. Here, we propose a generalized...

Obtaining accurate predictions of unobserved genetic or phenotypic values for complex traits in animal, plant, and human populations is possible through whole-genome prediction (WGP), a combined analysis genotypic data. Because the underlying architecture trait interest an important factor affecting model selection, we propose new strategy, termed BLUP|GA (BLUP-given architecture), which can use information within dataset at hand rather than from public sources. This achieved by using...

The shuttle effect of lithium polysulfides has been an important factor limiting the practical application lithium–sulfur batteries. CNF/Co-Co 9 S 8 -NC composites with a 3D hierarchical structure were prepared as polysulfide electrocatalyst.

Gene expression profiles potentially hold valuable information for the prediction of breeding values and phenotypes. In this study, utility transcriptome data phenotype was tested with 185 inbred lines Drosophila melanogaster 9 traits in two sexes. We incorporated into genomic via methods: GTBLUP GRBLUP, both combining single nucleotide polymorphisms data. The genotypic used to construct common additive relationship, which best linear unbiased (GBLUP) or jointly a mixed model...

Epistasis marker effect models incorporating products of values as predictor variables in a linear regression approach (extended GBLUP, EGBLUP) have been assessed potentially beneficial for genomic prediction, but their performance depends on coding. Although this fact has recognized literature, the nature problem not thoroughly investigated so far. We illustrate how choice coding implicitly specifies model effects certain allele combinations at different loci contribute to phenotype, and...

Abstract TEOSINTE BRANCHED 1/CYCLOIDEA/PCF (TCP) transcription factors play crucial roles in plant abiotic stresses. However, little is known about the role of TCP genes drought stress tolerance apple. Here, we found that abscisic acid (ABA) and treatment reduced expression MdTCP46 , overexpression ABA sensitivity resistance. was to interact with MdABI5 both vitro vivo, this interaction essential for resistance via ABA‐dependent pathway. Overexpression enhanced by directly activating MdEM6...

In the pig production industry, artificial insemination (AI) plays an important role in enlarging beneficial impact of elite boars. Understanding genetic architecture and detecting markers associated with semen traits can help improving selection for such accelerate progress. this study, we utilized a weighted single-step genome-wide association study (wssGWAS) procedure to detect regions further candidate genes Duroc boar population. Overall, full pedigree consists 5284 pigs (12...

For higher concrete strength, fiber-reinforced is a hot research topic. In the transportation process of concrete, flow characteristics are critical indicators pumping concrete. this paper, firstly, rheological steel measured based on small slump cylinder. The parameters, such as and expansion fiber reinforced with different proportions, analyzed, properties slurry tested by rheometer. Secondly, to realize effective prediction parameters Fluent numerical simulation software in computational...

With the aim to study flavor characteristics of Ningxiang pigs (NX), Duroc (DC) pigs, and their crosses (Duroc × Ningxiang, DN), electronic nose gas chromatography–mass spectrometry analysis were used detect volatile substances in NX, DC, DN (n = 34 per population). A total 120 detected three populations, which 18 common. Aldehydes main populations. Further revealed that tetradecanal, 2-undecenal, nonanal aldehyde kinds pork, relative content benzaldehyde populations had significant...

Background: A recent study reported that a deficiency of Col5a3 reduces dermal fat. However, the regulatory mechanism gene on adipose deposition remains unclear. Methods: In this study, we assessed effects interference proliferation and differentiation 3T3-L1 preadipocytes through CCK-8, EdU staining, cell cycle detection, RT-qPCR, Western blot, triglyceride assay, Oil Red O staining. RNA-seq was then performed differentiated adipocytes to identify key differentially expressed genes (DEGs)...

Meat production traits in pigs are critical economic characteristics, primarily influenced by the formation and development of skeletal muscle. Skeletal muscle is regulated a complex transcriptional network, which partly relies on chromatin accessibility for initiation. Ningxiang pigs, renowned Chinese indigenous breed, highly valued their tender meat. However, studies focusing particularly from perspective accessibility, have not yet been reported. Based this, present study selected several...

In this study, a combination of recombinant adenoviral p53 (rAd-p53) gene therapy and intra-arterial delivery chemotherapeutic agents for treatment oral squamous cell carcinoma was evaluated. total, 99 patients with stage III or IV who had refused were ineligible surgery enrolled in randomized, placebo-controlled, double-blind, phase clinical trial. They randomly assigned to group I (n = 35; infusion rAd-p53 plus chemotherapy), II 33; placebo 31; chemotherapy). The median length follow-up 36...

Abstract Gao et al. propose several approaches to incorporate gene annotation into genomic prediction and evaluate these new methods on populations..... Today, (GP) is an established technology in plant animal breeding programs. Current standard are purely based statistical considerations but do not make use of the abundant biological knowledge, which easily available from public databases. Major questions that have be answered before prior information can used routinely GP types used, at...

Genome-wide association studies and genomic predictions are thought to be optimized by using whole-genome sequence (WGS) data. However, sequencing thousands of individuals interest is expensive. Imputation from SNP panels WGS data an attractive less expensive approach obtain The aims this study were investigate the accuracy imputation provide insight into design execution genotype imputation.We genotyped 450 chickens with a 600 K array, sequenced 24 key whole genome re-sequencing. Accuracy...

Meat quality is an important trait for pig-breeding programs aiming to meet consumers' demands. Geneticists must improve meat based on their understanding of the underlying genetic mechanisms. Previous studies showed that most meat-quality indicators were low-to-moderate heritability traits; therefore, improving using conventional techniques remains a challenge. Here, we performed genome-wide association study traits GeneSeek Porcine SNP50K BeadChip in 582 crossbred Duroc × (Landrace...

The single-step covariance matrix H combines the pedigree-based relationship $${\mathbf {A}}$$ with more accurate information on realized relatedness of genotyped individuals represented by genomic {G}}$$ . In particular, to improve convergence behavior iterative approaches and reduce inflation, two weights $$\tau$$ $$\omega$$ have been introduced in definition {H}}^{-1}$$ , which blend inverse a part Since this blending is based equation describing its impact structure {H}}$$ not obvious....

Genomic prediction with imputed whole-genome sequencing (WGS) data is an attractive approach to improve predictive ability low cost. However, high accuracy has not been realized using this method in livestock. In study, we 435 individuals from 600K single nucleotide polymorphism (SNP) chip WGS different reference panels. We also investigated the of genomic best linear unbiased (GBLUP) panels, linkage disequilibrium (LD)-based marker pruning, and pre-selected variants based on Genome-wide...

In the genomes of diploid organisms, runs homozygosity (ROH), consecutive segments homozygosity, are extended. ROH can be applied to evaluate inbreeding situation individuals without pedigree data and detect selective signatures via islands. We sequenced analyzed derived from whole-genome sequencing 97 horses, investigated distribution genome-wide patterns, calculated ROH-based coefficients for 16 representative horse varieties around world. Our findings indicated that both ancient recent...

Introduction: The development of skeletal muscle is regulated by regulatory factors genes and non-coding RNAs (ncRNAs). Methods: objective this study was to understand the transformation fiber type in longissimus dorsi male Ningxiang pigs at four different growth stages (30, 90, 150, 210 days after birth, n = 3) histological analysis whole transcriptome sequencing. Additionally, investigated expression patterns various involved constructed a network for competing endogenous RNA (ceRNA) that...