A5100760142- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Analytical Chemistry and Chromatography
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Drug Transport and Resistance Mechanisms
- Urinary Bladder and Prostate Research
- Genetics and Plant Breeding
- Eicosanoids and Hypertension Pharmacology
- Medicinal Plants and Bioactive Compounds
- Medicinal Plant Pharmacodynamics Research
- Genetic Mapping and Diversity in Plants and Animals
- High Altitude and Hypoxia
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Lysosomal Storage Disorders Research
- Mitochondrial Function and Pathology
- Chemical Synthesis and Analysis
- Plant-based Medicinal Research
- Caveolin-1 and cellular processes
Rutgers New Jersey Medical School
2007-2025
Rutgers, The State University of New Jersey
2020-2025
Sun Yat-sen University
2024
Capital Medical University
2015-2024
Beijing Ditan Hospital
2024
Yangzhou University
2022-2024
Zhuhai People's Hospital
2023
Jinan University
2023
Regional Medical Center
2023
Shandong Agricultural University
2021-2023
Although the biological processes of organism under hypoxic stress had been elucidated, whole physiological changes Saccharomyces cerevisiae (S. cerevisiae) are still unclear. In this work, we investigated process S. hypoxia by methods transcriptomics, proteomics, metabolomics and bioinformatics. The results showed that expression a total 1017 mRNA in transcriptome, 213 proteins proteome 51 metabolites metabolome significantly changed between normoxia conditions. Moreover, based on...
We designed a novel isoliquiritigenin (ISL) loaded micelle prepared with DSPE-PEG
Stomatal density (SD) is closely related to crop drought resistance. Understanding the genetic basis for natural variation in SD may facilitate efforts improve water-use efficiency. Here, we report a genome-wide association study maize seedlings, which identified 18 variants that could be resolved seven candidate genes. A 3-bp insertion variant (InDel1089) last exon of Zea mays (Zm) IRX15A (Irregular xylem 15A) had most significant with and modulated translation ZmIRX15A mRNA by affecting...
The aim was to investigate the pharmacokinetic interaction between puerarin and edaravone, effect of borneol on brain distribution kinetics in rats.A reversed-phase high performance liquid chromatography method developed validated for simultaneous determination edaravone rat plasma. detection successfully applied compare using in-situ microdialysis sampling rats after intravenous administration co-administration with a single dose.The gave good linearity no endogenous material interfered two...
Lapachol is a natural naphthoquinone compound that possesses extensive biological activities. The aim of this study to investigate the inhibitory effects lapachol on rat C6 glioma both in vitro and vivo, as well potential mechanisms. antitumor effect was firstly evaluated model Wistar rats. cell proliferation, apoptosis DNA damage were detected by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS)/ phenazinemethosulfate (PMS) assay, hoechst 33358...
High temperatures are increasingly becoming a prominent environmental factor accelerating the adverse influence on growth and development of maize (
In order to investigate the pharmacokinetics of a combination diazepam and dexamethasone under hypoxic conditions, novel, sensitive specific liquid chromatography with tandem mass spectrometry (LC-MS/MS) method for simultaneous determination in rat plasma was developed validated. The chromatographic separation analytes successfully achieved on an XTerra® MS C18 column using gradient elution methanol water containing 0.1% formic acid at flow rate 0.5 mL/min. This demonstrated good linearity...
Abstract Albiflorin, a traditional Chinese herb, is main component of Radix paeoniae Alba , which has been used for the treatment depressive disorders since ancient times. However, mechanism antidepressant effect albiflorin poorly understood. Thus, we explored binding profile at neurotransmitter receptors and transporters. We also characterised in vivo on monoaminergic systems by using microanalysis to determine extracellular levels serotonin (5-HT) norepinephrine (NE) hypothalamus freely...
Preoperative anxiety is common and often comes with a higher probability of worse recovery. However, the neurological mechanism effect preoperative on general anesthesia subsequent awakening remains unknown. In this study, we report an anxious state results in delayed model mice from sevoflurane anesthesia. More profound inhibition DA neurons VTA contributes to awakening. Optogenetic stimulation can reverse delay. The indicate that may be involved delay caused by anxiety.
The olfactory system of insects is crucial in modulating behaviors such as host seeking, mating, and oviposition. Odorant-binding proteins (OBPs) are involved semiochemical recognition. OBPs recognize bind odorants transport them to odorant receptors located neurons. Harmonia axyridis (Coleoptera: Coccinellidae) a widely used predacious biological control agent for many agricultural forestry pests. This study identified 19 H. based on the antennal whole-body transcriptomes adults obtained...