A5040856831- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Cholesterol and Lipid Metabolism
- Cancer-related molecular mechanisms research
- Optical Network Technologies
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Nanoplatforms for cancer theranostics
- Wound Healing and Treatments
- Ferroptosis and cancer prognosis
- Infant Nutrition and Health
- Cancer Mechanisms and Therapy
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Cellular transport and secretion
- Neonatal Respiratory Health Research
- S100 Proteins and Annexins
Chongqing Medical University
2023-2025
Children's Hospital of Chongqing Medical University
2023-2025
Huazhong University of Science and Technology
2016-2025
Shanghai Jiao Tong University
2009-2025
Tongji Hospital
2006-2025
Beihang University
2024-2025
Shanghai Children's Hospital
2021-2025
Jilin University
2021-2025
Union Hospital
2014-2024
Union Hospital
2014-2024
Adjuvant chemotherapy in patients with stage III colon cancer prevents recurrence by eradicating minimal residual disease. However, which remain at high risk of after completing standard adjuvant treatment cannot currently be determined. Postsurgical circulating tumor DNA (ctDNA) analysis can detect disease and is associated colorectal cancers.To determine whether serial postsurgical postchemotherapy ctDNA could provide a real-time indication therapy efficacy cancer.This multicenter,...
Synaptic activity can boost neuroprotection through a mechanism that requires synapse-to-nucleus communication and calcium signals in the cell nucleus. Here we show hippocampal neurons nuclear is one of most potent neuronal gene expression. The induction or repression 185 activity-regulated genes dependent upon signaling. calcium-regulated pool contains genomic program mediates synaptic activity-induced, acquired neuroprotection. core set neuroprotective consists 9 principal components,...
Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis angiogenesis have appeared be promising direction. However, the current treatments failed coordinate simultaneously, leading an increased disability rate caused by DWs. Herein, whole-course-repair system introduced hydrogel concurrently achieve mutually supportive cycle of neurogenesis-angiogenesis under favorable immune-microenvironment. This can first one-step packaged syringe for...
In patients with ischemic heart disease, myocardial ischemia–reperfusion injury (IRI) can aggravate their condition even worse, and diabetes increases risk of IRI. Pathological pathways common diseases surgical operations like diabetes, obesity, coronary artery angioplasty, transplantation entail disorders iron metabolism. Ferroportin1 (FPN1) is the only mammalian protein associated release thus plays a vital role in homeostasis, while nuclear factor E2-related 2 (NRF2) controls...
Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune...
Traditional treatments against advanced non-small cell lung cancer (NSCLC) with high morbidity and mortality continue to be dissatisfactory. Given this situation, there is an urgent requirement for alternative modalities that provide lower invasiveness, superior clinical effectiveness, minimal adverse effects. The combination of photodynamic therapy (PDT) immunotherapy gradually become a promising approach high-grade malignant NSCLC. Nevertheless, owing the absence precise drug delivery...
Ethanol extract from <italic>Ganoderma lucidum</italic> (GL95), enriched with triterpenoids, has the potential to ameliorate lipid metabolic disorders, in part through modulating specific gut microbiota and regulating mRNA expression levels of genes involved cholesterol.
Acrylamide (AA) is a heat-induced toxicant, which can cause severe damage to health. In the present study, SD rats were used investigate potential therapeutic effects of allicin dietary supplementation in with AA-induced intestinal injury. The elevated expression occludin, claudin-1, zonula occludens-1 (ZO-1), mucin 2, and 3 indicated that oral alleviated epithelial barrier breakage induced by AA, compared AA-treated group. gut microbiota, Bacteroides, Escherichia_Shigella, Dubosiella,...
Mesenchymal stem cells (MSCs), with the capacity for self-renewal and differentiation into multiple cell types, exhibit property of homing towards tumor sites immunosuppression have been used as tumor-tropic vectors therapy. However, few studies investigated underlying molecular mechanisms that link MSCs to targeted cells. In this study, we elucidated inhibitory effects human bone marrow mesenchymal (hBMSCs) on glioma U251 using a co-culture system in vitro. The anti-tumor activity...
Abstract Background Cachexia is a multifactorial syndrome that highly prevalent in advanced cancer patients and leads to progressive functional impairments. The classification of cachexia stages essential for diagnosing treating cachexia. However, there lack simple tools with good discrimination classifying stages. Therefore, our study aimed develop clinically applicable staging score (CSS) validate its clinical outcomes different Methods Advanced were enrolled study. A CSS comprising the...
Atherosclerosis is a chronic vascular disease posing great threat to public health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities inhibit lipid accumulation and polarization conversion of macrophages then attenuate atherosclerotic lesions.All male Apolipoprotein E-deficient (ApoE-/-) mice were fed high-fat diet supplemented with RVS (10 mg/kg/day) or the same volume normal saline gavage for 20 weeks. The burden plaques in determined by histopathological staining....
This study investigated the physicochemical and flavor quality changes in fresh-cut papaya that was stored at 4 °C. Multivariate statistical analysis used to evaluate freshness of papaya. Aerobic plate counts were selected as a predictor papaya, prediction model for established using partial least squares regression (PLSR), support vector machine (SVMR) algorithms. Freshness could be well distinguished based on analyses. The aerobic counts, significantly correlated with storage time. SVMR...
Abstract Overall water splitting is a promising technology for sustainable hydrogen production, but the primary challenge removing bubbles from electrode surface quickly to increase production. Inspired by directional fluid transport properties of natural biological surfaces like Nepenthes peristome and Morpho butterfly's wings, here strategy demonstrated achieve highly efficient overall bubble‐guidance electrode, that is, an anisotropic groove‐micro/nanostructured porous (GMPE). Gradient...
Identification of the molecules that regulate priming synaptic vesicles for fusion and structural coupling calcium sensor with soluble N -ethyl maleimide sensitive factor adaptor protein receptor (SNARE)-based machinery is critical understanding mechanisms underlying calcium-dependent neurosecretion. Snapin binds to synaptosomal-associated 25 kDa (SNAP-25) enhances association SNARE complex synaptotagmin. In present study, we abolished snapin expression in mice functionally evaluated role...
The protein kinase C (PKC) family of proteins plays important roles in growth regulation and is implicated tumorigenesis. It has become clear that the role PKC tumorigenesis cell context dependent and/or isoform specific. In this study, we showed for first time by immunohistochemistry overexpression epsilon was detected vast majority (>90%) primary human non-small lung cancers (NSCLC) compared with normal epithelium. Inhibition pathway using a kinase-inactive, dominant-negative epsilon,...