A5101674410- Spinal Cord Injury Research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Cardiac Arrest and Resuscitation
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Healthcare Technology and Patient Monitoring
- Trauma and Emergency Care Studies
- Diabetic Foot Ulcer Assessment and Management
- Cardiac electrophysiology and arrhythmias
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Healthcare and Venom Research
- Sphingolipid Metabolism and Signaling
- Biological and pharmacological studies of plants
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Thermal Regulation in Medicine
- Acupuncture Treatment Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Chalcogenide Semiconductor Thin Films
- Phytochemical compounds biological activities
Third Affiliated Hospital of Sun Yat-sen University
2021-2025
Sun Yat-sen University
2021-2025
Nanjing Institute of Technology
2012-2024
National Medical Products Administration
2022-2024
Key Laboratory of Guangdong Province
2022-2024
Guangdong Provincial People's Hospital
2024
Lanzhou University
2019-2022
Lanzhou University Second Hospital
2019-2022
Guiyang Medical University
2021
Medizinische Hochschule Hannover
2021
Mesenchymal stem cells (MSCs), with the capacity for self-renewal and differentiation into multiple cell types, exhibit property of homing towards tumor sites immunosuppression have been used as tumor-tropic vectors therapy. However, few studies investigated underlying molecular mechanisms that link MSCs to targeted cells. In this study, we elucidated inhibitory effects human bone marrow mesenchymal (hBMSCs) on glioma U251 using a co-culture system in vitro. The anti-tumor activity...
Abstract Background Exosomes are nanoscale membrane vesicles secreted by both normal and cancer cells, cell-derived exosomes play an important role in the cross-talk between cells other cellular components tumor microenvironment. Mesenchymal stem (MSCs) have tropism for tumors been used as tumor-tropic vectors therapy; however, safety of such therapeutic use MSCs is unknown. In this study, we investigated glioma tumor-like phenotype transformation human bone marrow mesenchymal (hBMSCs)...
Abstract Over the past decade, we have witnessed development of cell transplantation as a new strategy for repairing spinal cord injury (SCI). However, due to complexity central nervous system (CNS), achieving successful clinical translation remains significant challenge. Human umbilical mesenchymal stem cells (hUMSCs) possess distinct advantages, such easy collection, lack ethical concerns, high self-renewal ability, multilineage differentiation potential, and immunomodulatory properties....
<title>Abstract</title> Spinal cord injury (SCI) leads to severe mitochondrial dysfunction and ROS cascade, with microglia playing a dual role in both exacerbating damage providing neuroprotection. Recent evidence has highlighted the importance of P2Y12R microglial-neuron interactions, particularly modulating quality control mitigating oxidative stress. Here, we develop dual-targeting nanoparticle system (P2Y-Nano) enhance expression activated promote neuronal mitophagy, aiming reduce...
Objective Quantitative ventricular fibrillation (VF) waveform analysis is a potentially powerful tool to optimize defibrillation. However, whether combining VF features with additional attributes that related the previous shock could enhance prediction performance for subsequent shocks still uncertain. Methods A total of 528 defibrillation from 199 patients experienced out-of-hospital cardiac arrest were analyzed in this study. was quantified using amplitude spectrum area (AMSA)...
Early cardiopulmonary resuscitation together with early defibrillation is a key point in the chain of survival for cardiac arrest. Optimizing timing by predicting possibility successful electric shock can guide treatments between and improve rate restoration spontaneous circulation. Numerous methods have been proposed success based on quantification ventricular fibrillation waveform during past decades. To date, however, no analytical technique has widely accepted clinical application. In...
Osteosarcoma (OS) is a malignant tumor prevalent in adolescents; however, clinically effective treatment for this malignancy lacking. The lack of methods and factors, such as recurrence drug resistance, further dampen the prospect treating OS. In recent years, small molecule microRNAs (miRNAs) with length approximately 20-24 nucleotides have gradually attracted attention medical community. Studies found that miRNAs can regulate cell cycle, apoptosis, proliferation, proliferation. metabolic...
Currently, although the improvement of surgical techniques and development chemotherapy drugs have brought a certain degree to treatment osteosarcoma, osteosarcoma has many shortcomings, its is limited. MiRNAs exosomes can be used as diagnostic tools, they play an important role in occurrence resistance osteosarcoma. Therefore, providing new method for key solving this problem. To systematically summarize research status exoskeleton drug-loaded miRNA we identified evaluated 208 studies found...